A5056717942- 3D Printing in Biomedical Research
- Toxic Organic Pollutants Impact
- Pluripotent Stem Cells Research
- Liver physiology and pathology
- Pharmacogenetics and Drug Metabolism
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Animal testing and alternatives
- Atmospheric chemistry and aerosols
- Effects and risks of endocrine disrupting chemicals
- Plant and animal studies
- Viral gastroenteritis research and epidemiology
- Statistical Methods in Clinical Trials
- Bird parasitology and diseases
- Metabolism and Genetic Disorders
- Insect and Pesticide Research
- Escherichia coli research studies
- Metabolomics and Mass Spectrometry Studies
- Environmental Toxicology and Ecotoxicology
- Cytomegalovirus and herpesvirus research
Texas A&M University
2020-2025
Abstract As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). Currently, many chemicals concern have limited experimental information available use in analytical assessments. Here, we aim increase this knowledge by providing scientific community with multidimensional characteristics 175 PFAS resulting 281 ion types. Using a platform coupling reversed-phase...
Avian decline is occurring globally with neonicotinoid insecticides posed as a potentially contributing factor. Birds can be exposed to neonicotinoids through coated seeds, soil, water, and insects, experimentally birds show varied adverse effects including mortality disruption of immune, reproductive, migration physiology. However, few studies have characterized exposure in wild bird communities over time. We hypothesized that would vary temporally based on avian ecological traits. were...
Background: Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority chemicals subject to numerous human health risk evaluations by a range of agencies. Metabolism TCE PCE determines their ultimate toxicity; important uncertainties exist in quantitative characterization metabolism genotoxic moieties through glutathione (GSH) conjugation species differences therein. Objectives: This study aimed address these using novel vitro liver models, interspecies comparison,...
In vitro cell-based toxicity testing methods generate large amounts of data informative for risk-based evaluations. To allow extrapolation the quantitative outputs from tests to equivalent exposure levels in humans, reverse toxicokinetic modeling is used conduct vitro-to-in vivo (IVIVE) effective concentrations oral dose equivalents. IVIVE approaches individual chemicals are well-established; however, potential implications chemical-to-chemical interactions mixture settings on remain largely...
The liver is one of the key organs for exogenous and endogenous metabolism often a target drug- chemical-driven toxicity. A wide range experimental approaches has been established to model characterize mechanisms chemical-induced hepatotoxicity. number microfluidics-enabled in vitro models have developed, but unclear translatability these platforms hindered their adoption by pharmaceutical industry; achieve use drug chemical safety evaluation, demonstration reproducibility robustness under...
The evaluation of exposure to multiple contaminants in a mixture presents number challenges. For example, the characterization chemical metabolism setting remains research area with critical knowledge gaps. Studies typically utilize suspension cultures primary human hepatocytes; however, this model is not suitable for studies more extended exposures and donor-to-donor variability metabolic capacity unavoidable. To address issue, we utilized several vitro models based on human-induced...
Cell-based testing of multi-constituent substances and mixtures for their potential adverse health effects is difficult due to complex composition physical-chemical characteristics. Various extraction methods are typically used enable studies in vitro; however, a limited number solvents biocompatible with vitro the extracts may not fully represent original test article's composition. While dosing "difficult-to-test" aquatic toxicity well defined widely used, they largely unsuited...