A5051157761- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Non-Invasive Vital Sign Monitoring
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Hemodynamic Monitoring and Therapy
- Parathyroid Disorders and Treatments
- Diabetes Management and Research
- Vitamin K Research Studies
- Renal function and acid-base balance
Aarhus University Hospital
2021-2024
ABSTRACT Background Dapagliflozin and finerenone reduce albuminuria slow CKD progression, but additive effects remain unstudied. We compared their individual combined efficacy safety in patients with non-diabetic CKD. Methods In an open-label, randomized clinical trial, we included aged 18–80 on maximal tolerated ACE inhibitor or angiotensin receptor blocker eGFR 25–45 mL/min/1,73 m2 150–2000 mg/g. Participants received either 20 mg/day dapagliflozin 10 for four weeks, followed by...
Chronic kidney disease (CKD) is associated with accelerated vascular calcification and increased central systolic blood pressure when measured invasively (invCSBP) relative to cuff-based brachial (cuffSBP). The contribution of aortic wall this phenomenon has not been clarified. We, therefore, examined the effects on cuffSBP invCSBP in a cohort patients representing all stages CKD.
Patients with chronic kidney disease (CKD) are susceptible to vascular calcification and vitamin K deficiency. Matrix gla protein (MGP) is a potent inhibitor of requiring for activation. Inactive MGP, i.e. dephosphorylated uncarboxylated MGP (dp-ucMGP), frequently elevated in CKD along induced by absence (PIVKA-II). We investigated whether dp-ucMGP PIVKA-II useful markers aortic CKD. normal or reduced function underwent non-contrast computed tomography scan the entire aorta subsequent...
Abstract Ambulatory blood pressure monitoring (ABPM) may be stressful and associated with discomfort, possibly influenced by the number of cuff inflations. We compared a low frequency (LF-ABPM) regimen one inflation per hour, high (HF-ABPM) performed according to current guidelines using three cuff-inflations hour during daytime two night time. In crossover study, patients underwent ABPMs both frequencies, in randomized order, within an interval few days. Patients reported pain (visual...
Chronic kidney disease (CKD) and arterial stiffness are associated with increased central (aortic) systolic blood pressure (cSBP) relative to brachial (bSBP). This study examined the impact of aortic calcification on cSBP bSBP in patients CKD.Patients or without CKD undergoing elective coronary angiography (CAG) at Aarhus University Hospital were considered for inclusion this cross-sectional study. During CAG, was measured ascending aorta a fluid-filled catheter while simultaneously an...
Twenty-four hours of ambulatory blood pressure monitoring (ABPM) is recommended in several guidelines as the best method for diagnosing hypertension. In general, prognostic value ABPM superior to single office (BP) measurements. Unfortunately, some patients experience considerable discomfort during frequently repeated forceful cuff inflations.In this study we investigated difference mean daytime systolic BP (SBP) between low-frequency (LF-ABPM), measuring once every hour, and high-frequency...
We investigated whether the cuff inflation interval affects 24-hour ambulatory blood pressure monitoring (ABPM) values in patients with hypertension (HT).HT (18+ years), typically office BP above treatment target, were recruited from hospital clinic and 2 private cardiology clinics. Using a crossover study design, participants andomised to either high or low measurement frequency ABPM (HF-ABPM LF-ABPM, respectively). HF-ABPM measured 3 times hourly during daytime nighttime, while LF-ABPM...