A5087726829- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Retinal and Optic Conditions
- Extracellular vesicles in disease
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- MicroRNA in disease regulation
- Retinal Imaging and Analysis
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
Weifang People's Hospital
2018-2019
Qilu Hospital of Shandong University
2015-2017
Shandong University
2017
Corneal endothelial dysfunction occurs when corneal cells (CECs) are dramatically lost and eventually results in vision loss. transplantation is the only solution at present. However, requires a fresh human cornea there worldwide shortage of donors. Therefore, finding new functional CECs to replace urgent. Skin-derived precursors (SKPs) can be easily acquired have multiple differential potential. We co-cultured SKPs with B4G12 serum-free medium obtained abundant CEC-like which had similar...
The development of cell-based therapies using stem cells represents a significant breakthrough in the treatment limbal cell deficiency (LSCD). aim this study was to develop novel protocol differentiate human embryonic (hESCs) into corneal epithelial progenitor (CEPCs), with similar features primary cultured (LSCs), medium composed DMEM/F12 and defined keratinocyte serum-free (KSFM) (1:1) under different carbon dioxide (CO2) levels culture. differentiated exhibited morphology 5%, 7%, 9% CO2...
Corneal endothelial dysfunction causes severe impairment of vision. The only solution is corneal transplantation. However, this treatment hampered by a worldwide shortage donor corneas. New therapies may replace the conventional transplantation alongside developments in regenerative medicine and tissue engineering, but sufficient functional cells (CECs) are essential. aim study was to promote expansion function human (HCECs) vitro vivo. phenotypes orbital adipose-derived stem (OASCs) were...
AIM: To investigate the feasibility of corneal anterior lamellar reconstruction with human epithelial cells and fibroblasts, an acellular porcine cornea matrix (APCM) in vitro. METHODS: The scaffold was prepared from fresh corneas which were treated 0.5% sodium dodecyl sulfate (SDS) solution complete removal confirmed by hematoxylin-eosin (HE) staining 4’, 6-diamidino-2-phenylindole (DAPI) staining. Human fibroblasts cultured leaching liquid extracted APCM, then cell proliferative ability...
To investigate the expression of Matrix Metalloproteinases 2 and aquaporin-1 in corneoscleral junction explore mechanism trabecular damageafter angle-closure.Thirty New Zealand white rabbits were randomly assigned into groups, theexperimental group (Group 1) including twenty five control 2) 5 rabbits. The experimental used to establish angle-closure models, not subjected any operation. All followed by slit lamp microscopy, Tonopen tonometer, anterior segment optical coherent tomography...
Abstract Rationale: The case with congenital macular coloboma and cataract was rarely reported, the pathogenic gene of disease is still not clear. Moreover, it difficult to improve visual acuity eye this disease. Patient concerns: An 11-year-old boy presented low horizontal nystagmus in both eyes. Ophthalmologic examination showed patient bilateral cataract. improved slightly after surgery. Heterozygous mutations frizzled-4 (FZD4) nucleotide-binding oligomerization domain-containing protein...
Corneal transplantation is the most effective treatment for corneal blindness at present, but shortage of cornea donation and graft rejection are serious obstacles its broad application.Construction tissue-engineered substitutes with good biocompatibility normal biological function emerging as a potential approach to overcome shortages donor corneas, which will be source grafts transplantation.With development in technology biomaterials, cell culture tissue engineering, field engineering has...