A5115596357- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Advanced Photocatalysis Techniques
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Diet, Metabolism, and Disease
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- CAR-T cell therapy research
- Intracerebral and Subarachnoid Hemorrhage Research
- Ferroptosis and cancer prognosis
- Pharmacy and Medical Practices
- Medical Imaging Techniques and Applications
- Urban Heat Island Mitigation
- Metabolomics and Mass Spectrometry Studies
- Nanocomposite Films for Food Packaging
- Thermal Radiation and Cooling Technologies
- Forest ecology and management
- Plant biochemistry and biosynthesis
- Gastric Cancer Management and Outcomes
- Protein Degradation and Inhibitors
- Bladder and Urothelial Cancer Treatments
- Dementia and Cognitive Impairment Research
- Vector-Borne Animal Diseases
University of Virginia
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Peking Union Medical College Hospital
2011-2025
China University of Petroleum, East China
2024-2025
Shandong University
2024-2025
Hebei University of Technology
2024-2025
Shanghai Normal University
2025
First Affiliated Hospital of Henan University
2024-2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2025
Spiking neural networks (SNNs) are attracting increasing interests for their ability to emulate biological processes, offering energy-efficient computation and event-driven processing. Currently, no devices known combine both neuronal synaptic functions. This study presents an experimental demonstration of ambipolar WSe
Apolipoprotein-E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD). Current studies, which were mainly based on the clinical diagnosis rather than biomarkers, come to inconsistent conclusions regarding associations of APOE homozygotes (APOE ε4/ε4) and cerebrospinal fluid (CSF) biomarkers AD. In addition, few studies have explored ε4/ε4 with plasma biomarkers. Therefore, we aimed investigate in dementia biomarker-diagnosed AD.A total 297 patients enrolled. They classified...
To observe the effects of electroacupuncture (EA) at "Shenting" (GV24) and "Baihui" (GV20) on mitochondrial autophagy in hippocampal neurons silent information regulator sirtuin 1 (Sirt1)/forkhead box O3 (FOXO3)/PTEN-inducible kinase (PINK1)/Parkin pathway rats with learning-memory impairment after cerebral ischemia reperfusion injury. A total 35 male SD were randomly divided into a sham operation group (9 rats) modeling (26 rats). In group, middle artery occlusion method was used to...
<title>Abstract</title> While microbial cells have emerged as a versatile platform for the synthesis of metal nanoparticles, their application production single-atom catalysts (SACs) has been rarely studied yet. Here, we develop facile method ambient SACs with high loading >4.0 wt% by in-situ reduction ions on overexpressing catalytically active enzyme (e.g., alcohol dehydrogenase (ADH), amine and monoamine oxidase), producing chemo-bio bifunctional (SAC@cell). The ADH-overexpressed...
To investigate the pathogenesis of high-altitude cerebral edema (HACE) and develop new therapeutic strategies. Male Sprague-Dawley (SD) rats 6 weeks old were selected placed in a hypobaric chamber. The exposed to environment 7000 m above sea level for 3 days HACE modeling. Whether model was successfully established evaluated by measuring brain water content, degree disruption blood-brain barrier (BBB), tissue Nissl staining. experimental animals divided into four groups, with 28 each group....
Abstract Mantle cell lymphoma (MCL) is a rare and aggressive form of B-cell that characterized by aberrations in receptor signaling BCL-2-mediated apoptotic pathways. MCLs treated with inhibitors either have shown remarkable response rates but ultimately develop drug resistance, patients suffering from rapid disease progression experiencing poor clinical outcomes. Preclinical studies into the Bruton’s tyrosine kinase inhibitor ibrutinib BCL-2 ABT-199 (venetoclax) revealed they were...
Background and Objectives: Identifying carriers of Pathogenic/Likely Pathogenic Variants in patients with dementia is crucial for risk stratification, particularly individuals a family history. This study developed validated clinical prediction model using whole-exome sequencing-confirmed cohorts. Methods: A total 601 Chinese history were enrolled at Peking Union Medical College Hospital, 476 retrospective derivation cohort 125 temporal validation cohort. Predictive factors included age...
To investigate whether apelin-13 induced THP-1 monocytes (MCs) adhesion to ECV304 human umbilical vein endothelial cells (HUVECs) via 14-3-3 signaling transduction pathway and the potential novel physiological function of apelin-APJ, HUVECs were cultured in DMEM MCs RPMI 1640 medium. Monocyte expression vascular cell molecule-1 (VCAM-1) measured with monocyte assay western blot analysis. Data showed that increased a concentration- time-dependent manner, which reached their peaks at 1 mM 12...