A5100399624- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
- Autophagy in Disease and Therapy
- Drug Solubulity and Delivery Systems
- Alzheimer's disease research and treatments
- Plant-Microbe Interactions and Immunity
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Advanced Drug Delivery Systems
- Muscle metabolism and nutrition
- Cancer Research and Treatments
- RNA modifications and cancer
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cancer-related Molecular Pathways
- Postharvest Quality and Shelf Life Management
- Plant Pathogens and Fungal Diseases
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shandong Agricultural University
2024
Northeastern University
2014-2024
University of South China
2024
Huazhong Agricultural University
2022
Tianjin Medical University
2021
In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG for efficient brain-targeted delivery of siRNA. The physiochemical properties complexes, such as siRNA complexing ability, size and ζ potential, morphology, serum stability, cytotoxicity, were investigated prior studying cellular uptake, in vitro gene silencing efficiency, vivo biodistribution. RVG-peptide-linked siRNA/TMC-PEG showed...
Ferroptosis is characterized as an iron-dependent and lipophilic form of cell death. However, it remains unclear what role ferroptosis has in adipose tissue function activity. Here, we find a lower ferroptotic signature the individuals mice with obesity. We further that activation signaling by non-lethal dose agonists significantly reduces lipid accumulation primary adipocytes high-fat diet (HFD)-fed mice. Notably, adipocyte-specific overexpression acyl-coenzyme A synthetase long-chain...
B‐cell receptor‐associated protein 31 (BAP31) is a ubiquitously expressed endoplasmic reticulum (ER) membrane that has been found to be overexpressed in gastric intestinal‐type adenocarcinoma. We first studied the relationship of BAP31 with 84 kinds tumor‐associated antigens and can specifically interact regulate proteasome degradation cyclin kinase inhibitor p27 kip1 , which one most frequently dysregulated tumor suppressor proteins human cancers. Therefore, we screened antibodies against...
Background B-cell receptor–associated protein 31 (BAP31) has been recognized as a tumor-associated and largely shown to promote metastasis in variety of cancers. Cancer arises through multistep pathways, the induction angiogenesis is be rate-limiting step process tumor metastasis. Methods results This study explored effect BAP31 on colorectal cancer (CRC) by regulating microenvironment. First, exosomes from BAP31-regulated CRCs affected transition normal fibroblasts proangiogenic...
Uniform mesoporous carbon spheres (UMCS) were used as a carrier to improve the bioavailability of model drug, celecoxib (CEL). Furthermore, we investigated mechanism responsible for improved CEL. The association, adhesion and uptake UMCS by intestinal epithelial cells studied transmission electron microscopy (TEM), fluorescence-activated cell sorting (FACS) laser confocal scanning (LCSM). was found promote cellular Drug transport in Caco-2 monolayers proved that can significantly reduce rate...
Neuroblastoma (NB) is one of the highly vascularized childhood solid tumors, and understanding molecular mechanisms underlying angiogenesis in NB crucial for developing effective therapeutic strategies. B-cell receptor-associated protein 31 (BAP31) has been implicated tumor progression, but its role remains unexplored. This study investigated BAP31 modulation pro-angiogenic factors SH-SY5Y cells. Through overexpression, knockdown, antibody blocking, quantification experiments, we...
Background and Objectives: Identifying carriers of Pathogenic/Likely Pathogenic Variants in patients with dementia is crucial for risk stratification, particularly individuals a family history. This study developed validated clinical prediction model using whole-exome sequencing-confirmed cohorts. Methods: A total 601 Chinese history were enrolled at Peking Union Medical College Hospital, 476 retrospective derivation cohort 125 temporal validation cohort. Predictive factors included age...
Reticulon (RTN) 3 reduces amyloid-β (Aβ) plaques (APs) by negative modulation of β-secretase 1 (BACE1) activity. However, RTN3 aggregates easily, which offsets RTN3's inhibitory effect on BACE1 activity and exacerbates AP deposition. We found that BAP31 was a binding partner positively correlated with the expression level RTN3. To further explore how is involved in Alzheimer's disease (AD), conditional knockout mice targeted deletion (B-KO) hippocampus cerebral cortex were generated...
The severity of Verticillium wilt on cotton caused by defoliating strains dahliae has gradually increased and threatens production worldwide. Identification the molecular components leaf defoliation may increase tolerance to V. dahliae. Ethylene, a major player in plant physiological processes, is often associated with senescence plants. We investigated cotton–V. interaction focus role ethylene defense against Cotton plants inoculated isolate V991, strain, accumulated more showed disease...
Increased stemness is causally linked to the development of chemoresistance in cancers. B-cell receptor-associated protein 31 (BAP31) has been identified play an oncogenic role many types cancer. However, BAP31 5-fluorouracil (5-FU) chemosensitivity and colorectal cancer (CRC) still unknown. The aim this study was investigate biological function molecular mechanism regulating 5-FU stemness. correlation between expression examined using...
B-cell receptor-associated protein 31 (Bap31) is an evolutionarily conserved, ubiquitously expressed, polytopic integral membrane in the endoplasmic reticulum (ER) that involved regulation of apoptosis, transport and degradation. Patients with Bap31 mutations exhibit symptoms similar to those exhibited by patients central nervous system (CNS) diseases, such as deafness, dystonia, intellectual disability. The present study aimed investigate function CNS diseases identifying a disease-related...
SESN2 and JNK are emerging powerful stress-inducible proteins in regulating lipid metabolism. The aim of this study was to determine the underlying mechanism SESN2/JNK signaling exercise improve disorder induced by high-fat diet (HFD). Our data showed that HFD knockout resulted abnormalities including elevated body weight, increased fat mass, serum total cholesterol, biosynthesis related proteins, a concomitant increase pJNK-Thr183/Tyr185. above changes were reversed training. silencing or...
Dysregulated B cell receptor-associated protein 31 (BAP31) plays a crucial role in tumor progression. This study aimed to investigate the functions and molecular mechanism of BAP31 on miR-206/133b cluster colorectal cancer (CRC). qPCR was conducted detect miRNA mRNA levels tissues cells. Western blot assays were used assess biomarkers targets, as well HOXD10. Wound healing, coculture transwell transendothelial migration abilities CRC A luciferase assay employed binding effects initiating...
The expression of B-cell receptor associated protein 31 (BAP31) is increased in many tumor types, and it reported to participate proliferation, migration, apoptosis. However, the relationship between BAP31 chemoresistance uncertain. This study investigated role regulating doxorubicin (Dox) resistance hepatocellular carcinoma (HCC). proteins was assessed by Western blotting. correlation Dox examined MTT colony formation assays. Apoptosis analyzed flow cytometry TdT-mediated dUTP nick end...
To investigate the effects of individual essential amino acids (EAA) on growth and underlying mechanisms, EAA individually supplemented a low-protein (LP) diet fed to young rats in present study. Treatments were an LP that contained 6% crude protein (CP), high-protein (HP) 18% CP, 10 diets with achieve supply equal HP diet. The CP concentration was ascertained from results first experiment, which examined dietary concentrations rates, ranging 2% 26%. Weight gain increased supplementation...
The epithelial cell-adhesion molecule (EpCAM) is hyperglycosylated in carcinoma tissue and the oncogenic function of EpCAM primarily depends on degree glycosylation. Inhibiting glycosylation expected to have an inhibitory effect cancer. We analyzed relationship BAP31 with 84 kinds tumor-associated antigens found that positively correlated protein level EpCAM. Triple mutations N76/111/198A, which are no longer modified by glycosylation, were constructed determine whether has Plasmids...