A5088983921- Radioactive element chemistry and processing
- Chemical Synthesis and Characterization
- Extraction and Separation Processes
- Radioactive contamination and transfer
- Radiopharmaceutical Chemistry and Applications
- Protease and Inhibitor Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Medical Imaging and Pathology Studies
- Analytical chemistry methods development
- Blood Coagulation and Thrombosis Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Nuclear materials and radiation effects
- Scientific Measurement and Uncertainty Evaluation
- Advanced Condensed Matter Physics
- RNA modifications and cancer
- Inorganic Fluorides and Related Compounds
- Graphite, nuclear technology, radiation studies
- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
Battelle
2016-2022
Pacific Northwest National Laboratory
2010-2022
Richland College
2016
University of North Carolina at Chapel Hill
2003-2012
Vanderbilt University
2011
Argonne National Laboratory
2010
University of North Carolina Health Care
2009
UNC Lineberger Comprehensive Cancer Center
2003
The Actinide-Lanthanide SEParation (ALSEP) concept is described. This based on using an extractant phase consisting of either N,N,N’,N’-tetraoctyldiglycolamide (TODGA) or N,N,N’,N’-tetra(2-ethylhexyl)diglycolamide (T2EHDGA) combined with 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) to separate Am and Cm from lanthanide other fission activation products in a single solvent extraction cycle. neutral TODGA T2EHDGA serves co-extract the trivalent actinide ions nitric media....
Breast cancer is the most prominent among females in United States. There are a number of risk factors associated with development breast cancer, including consumption high‐fat diet and obesity. Plasminogen activator inhibitor‐1 (PAI‐1) cytokine upregulated obesity whose expression correlated poor prognosis cancer. As key mediator adipogenesis regulator adipokine production, peroxisome proliferator‐activated receptor‐ γ (PPAR‐ ) involved PAI‐1 from adipose tissue. We summarize current...
Abstract Combining octyl(phenyl)-N,N-diisobutyl-carbamoylmethyl-phosphine oxide (CMPO) and bis-(2-ethylhexyl) phosphoric acid (HDEHP) into a single process solvent for separating transuranic elements from liquid high-level waste is explored. Co-extraction of americium the lanthanide nitric solution possible with mixture consisting 0.1 M CMPO plus 1 HDEHP in n-dodecane. Switching aqueous-phase chemistry to citrate-buffered diethylene triamine pentaacetic (DTPA) allows selective stripping...
A method for separating the trivalent actinides and lanthanides is being developed using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) as extractant. The based on preferential binding of in aqueous phase by N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic (HEDTA), which serves to keep while are extracted into an organic containing HEH[EHP]. process very robust, showing little dependence upon pH or HEH[EHP], HEDTA, citrate concentrations over ranges that might be expected...
Abstract Combining octyl(phenyl)-N,N-diisobutyl-carbamoylmethylphosphine oxide (CMPO) and 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) into a single process solvent for separating transuranic elements from liquid high-level waste is explored. The lanthanides americium can be co-extracted HNO3 0.2 mol/L CMPO + 1.0 HEH[EHP] in n-dodecane. extraction relatively insensitive to the concentration within 0.1–5 HNO3. Americium selectively stripped CMPO/HEH[EHP] citrate-buffered...
Magnetic nanoparticles are well known to possess chemically active surfaces and large surface areas that can be employed extract a range of ions from aqueous solutions. Additionally, their superparamagnetic properties provide convenient means for bulk collection the material solution after targeted have been adsorbed. Herein, two nanoscale amphoteric metal oxides, each possessing useful magnetic attributes, were evaluated ability collect trace levels diverse alpha emitting radioactive...
Abstract We have previously mapped a liver tumor suppressor locus to human chromosome 11p11.2‐p12 using functional model of suppression. Using this system, we employed candidate gene approach identify potential genes. Thirty‐eight known genes been positioned in by the Human Genome Project. Here show that four these (guanine nucleotide binding protein gamma 3; mitochondrial carrier homolog 2; p53‐induced ( PIG11 ), and pRDI‐BF1‐rIZ1 domain containing 11) localized minimal region within...
In the event of an accidental or intentional release radionuclides into a populated area, massive numbers people may require radiobioassay screening as triage for dose-reduction therapy identification longer-term follow-up. If released significant levels beta- alpha-emitting radionuclides, in vivo assays would be ineffective. Therefore, highly efficient and rapid analytical methods radionuclide detection from submitted spot urine samples (≤50 mL) required. At present, quantitative...
We investigated peroxisome proliferator-activated receptor- γ (PPAR- ) ligands effect on cell motility and the plasminogen activator system using normal MCF-10A malignant MCF-10CA1 lines. Ciglitazone reduced both wound-induced migration chemotaxis. However, was not reversed with pretreatment of cells PPAR- -specific antagonist GW9662. Immunoblot analysis conditioned media showed ciglitazone decreased inhibitor-1 (PAI-1) in lines; this also unaltered by antagonism. Alternatively, treatment ω...
Fluorine-19 magnetic shielding tensors have been measured in a series of actinide tetrafluorides (AnF4) by solid state nuclear resonance spectroscopy. Tetravalent centers with 0–8 valence electrons can form the same monoclinic structure type, making these compounds an attractive choice for systematic study variation electronic across 5f row Periodic Table. Pronounced deviations from predictions based on localized electron models detected experiments, which suggests that this approach may be...