A5079847042- Lipid metabolism and biosynthesis
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Neuroscience and Neural Engineering
- Cholesterol and Lipid Metabolism
- CRISPR and Genetic Engineering
- Endoplasmic Reticulum Stress and Disease
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
Nanyang Technological University
2022-2024
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder affecting millions of elderly individuals worldwide. Clinically, PD diagnosed based on the presentation motoric symptoms. Other methods such as F-DOPA PET scan or α-Synuclein detection from cerebral spinal fluid are either too expensive invasive for routine use. Omics platforms transcriptomics, proteomics, and metabolomics may identify biomarkers blood, which can reduce cost increase efficiency. However, there many...
Abnormal lipid homeostasis has been observed in the brain of Parkinson's disease (PD) patients and experimental models, although mechanism underlying this phenomenon is unclear. Notably, previous studies have reported that PD-linked protein Parkin functionally interacts with important regulators, including Sterol Regulatory Element-Binding Proteins (SREBPs) cluster differentiation 36 (CD36). Here, we demonstrate a functional relationship between lipoprotein lipase (LPL), triglyceride widely...