A5084632522- Veterinary Pharmacology and Anesthesia
- Gut microbiota and health
- Animal testing and alternatives
- DNA Repair Mechanisms
- Inflammatory Bowel Disease
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Reproductive System and Pregnancy
- Inhalation and Respiratory Drug Delivery
- Adipose Tissue and Metabolism
- Veterinary Orthopedics and Neurology
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Veterinary Oncology Research
- Human-Animal Interaction Studies
- Endometriosis Research and Treatment
- IL-33, ST2, and ILC Pathways
- Neuropeptides and Animal Physiology
- Endometrial and Cervical Cancer Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Species Distribution and Climate Change
University of Michigan
2012-2024
Case Western Reserve University
2015
Michigan State University
2012
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and increasing in industrialized populations. Combined with host genetics, diet gut bacteria thought to contribute prominently IBDs, but mechanisms still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived microbiota promotes deterioration colonic mucus, leading lethal colitis. Inflammation starts expansion natural killer...
Pulmonary fibrosis is a chronic and often fatal disease. The pathogenesis characterized by aberrant repair of lung parenchyma resulting in loss physiological homeostasis, respiratory failure death. immune response pulmonary dysregulated. gut microbiome key regulator immunity. role the regulating immunity poorly understood. Here, we determine impact microbiota on C57BL/6 mice derived from different vendors (C57BL/6J C57BL/6NCrl). We use germ free models, fecal transplantation cohousing to...
Buprenorphine is commonly used to control postoperative pain in rodents. Short-acting formulations of buprenorphine (bup-HCl) require frequent handling and restraint animals for appropriate dosing, which can be stressful confound research outcomes. Ethiqa XR (bup-ER) an FDA-indexed extended-release formulation that alternative bup-HCl mice rats. In the current study, we first evaluated pharmacokinetics bup-ER male C57BL/6J by sampling blood at 10 time points, ranging from 30 min 72 h after...
Abstract Inflammatory bowel disease (IBD) is a chronic condition characterized by periods of spontaneous intestinal inflammation and increasing in industrialized populations. Combined with host genetic predisposition, diet gut bacteria are thought to be prominent features contributing IBD, but little known about the precise mechanisms involved. Here, we show that low dietary fiber promotes bacterial erosion protective colonic mucus, leading lethal colitis mice lacking IBD-associated...
Summary Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and increasing in industrialized populations. Combined with host genetics, diet gut bacteria thought to contribute prominently IBDs, but mechanisms still emerging. In mice lacking the IBD-associated cytokine, Interleukin-10, we show that low dietary fiber promotes bacterial erosion colonic mucus, leading lethal colitis. A fiber-free exclusive enteral nutrition...
right ear base for an unknown duration, and purulent discharge was often noted draining from the mass into canal when palpated.At this facility, rats were kept in wire cages (5 to 8 rats/cage).No sick animals colony had previously been
Abstract OBJECTIVE To determine long-term outcome for rhesus macaques ( Macaca mulatta ) with endometriosis that underwent surgical treatment and identify factors potentially associated outcome. DESIGN Retrospective case series. ANIMALS 11 female macaques. PROCEDURES Medical records of in which was diagnosed between 2007 2011 abdominal exploratory surgery were reviewed. RESULTS In 5 macaques, the only clinical abnormality a caudal mass identified during routine physical examination, 6 overt...
Abstract One of the major health concerns on long-duration space missions will be radiation exposure to astronauts. Outside earth's magnetosphere, astronauts exposed galactic cosmic rays (GCR) and solar particle events that are principally composed protons He, Ca, O, Ne, Si, Fe nuclei. Protons by far most common species, but higher atomic number particles thought more damaging biological systems. Evaluation amelioration risks from GCR important for deep travel. The hematopoietic system is...
Inhalant anesthesia is routinely used for cesarian section in many animal species, allowing the safe delivery of neonates and smooth recovery dams. However, mice, inhalant cesarean may be avoided due to fear negative health effects on retrieved pups. This study compared isoflurane pups after cervical dislocation conscious anesthetized Time-mated C57BL/6J dams were either with 5% or during dislocation. Rederived fostered Swiss Webster weaned at 21 d. Weights litters recorded birth, individual...