A5042222766- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Nutritional Studies and Diet
- Nuts composition and effects
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Tea Polyphenols and Effects
- Gut microbiota and health
- Natural Antidiabetic Agents Studies
- Nutrition, Genetics, and Disease
- Vitamin C and Antioxidants Research
- Garlic and Onion Studies
- Free Radicals and Antioxidants
- Fatty Acid Research and Health
- Muscle metabolism and nutrition
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Pharmacology and Obesity Treatment
- Obesity, Physical Activity, Diet
- Ginkgo biloba and Cashew Applications
- Diet, Metabolism, and Disease
- Pharmacological Effects and Toxicity Studies
Agricultural Research Service
2015-2024
Beltsville Human Nutrition Research Center
2015-2024
United States Department of Agriculture
2003-2021
Beltsville Agricultural Research Center
2008-2018
Institute of Cardiology
2012
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2012
University College London
2012
Medical University of Graz
2012
Leiden University Medical Center
2012
Charles University
2012
A physiological compartmental model of α-linolenic acid metabolism was derived from the plasma concentration-time curves for d5-18:3n-3, d5-20:5n-3, d5-22:5n-3, and d5-22:6n-3 in eight healthy subjects. Subjects received a 1-g oral dose an isotope tracer α-linolenate (d5-18:3n-3 ethyl ester) while subsisting on rigorously controlled beef-based diet. By utilizing Windows Simulation Analysis Modeling program, kinetic parameters were determined each subject. Half-lives mean transit times n-3...
Many tropical fruits are rich in anthocyanins, though limited information is available about the characterization and quantification of these anthocyanins. The identification anthocyanin pigments four were determined by HPLC-MS/MS. Fruits studied included acerola (Malphigia emarginata), jussara (Euterpe edulis), jambolão (Syzygium cumini), guajiru (Chrysobalanus icaco). All found to contain pigments. Anthocyanidin backbones cyanidin, delphinidin, peonidin, pelargonidin, petunidin, malvidin....
The bioavailability of acylated vs nonacylated anthocyanins and the effect cooking dose on comparative were investigated in a clinical feeding study using purple carrots as anthocyanin source. Treatments follows: 250 g raw (463 μmol anthocyanins: 400 acylated, 63 nonacylated), cooked (357 308.5 48.5 500 (714 617 97 nonacylated). Four five carrot found intact plasma by 30 min after consumption peaked between 1.5 2.5 h. Acylation resulted an 11−14-fold decrease recovery urine 8−10-fold plasma....
Recent studies indicate that anthocyanin intake conveys a variety of health benefits, which depend on absorption and metabolic mechanisms deliver anthocyanins their bioactive metabolites to responsive tissues. The bioavailability red cabbage (Brassica oleracea L. var. capitata) was evaluated as reflected by urinary excretion metabolites. Twelve volunteers consumed 100, 200, 300 g steamed (containing 1.38 μmol anthocyanins/g cabbage) in crossover design. Anthocyanin concentration extract...
Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer heart disease. Although there is accumulating preclinical evidence walnuts beneficially affect the gastrointestinal microbiota gut metabolic health, these relations not been investigated humans.We aimed to assess impact of walnut consumption on human markers health.A controlled-feeding, randomized crossover study was undertaken healthy men women...
The modification of microbiota composition to a ‘beneficial’ one is promising approach for improving intestinal as well overall health. Natural fibres and phytochemicals that reach the proximal colon, such those present in various nuts, provide substrates maintenance healthy diverse microbiota. effects increased consumption specific which are rich fibre phytonutrients, on human gut have not been investigated date. objective study was determine almond pistachio composition. We characterised...
Absorption of cyanidin-based anthocyanins is not fully understood with respect to dose or anthocyanin structure. In feeding studies using whole foods, nonacylated are more bioavailable than their acylated counterparts, but the extent which plant matrix determines relative bioavailability unknown. Using juice purple carrots circumvent effects, a trial was conducted determine and assess dose−response effects. Appearance in plasma measured 10 healthy adults for 8 h following consumption carrot...
Background: Almond processing has been shown to differentially impact metabolizable energy; however, the effect of food form on gastrointestinal microbiota is under-investigated. Objective: We aimed assess interrelationship almond consumption and microbiota. Design: A controlled-feeding, randomized, five-period, crossover study with washouts between diet periods was conducted in healthy adults (n = 18). Treatments included: (1) zero servings/day almonds (control); (2) 1.5 servings (42 g)/day...
Shades ranging from violet to black pigmentation in pepper (Capsicum annuum L.) are attributed anthocyanin accumulation. High-performance liquid chromatography and mass spectrometry analysis of fruit tissue identified a single that was determined be delphinidin-3-p-coumaroyl-rutinoside-5-glucoside. Leaf black-pigmented foliage genotype contained the same found but at considerably higher concentration comparison tissue. Fruit chlorophyll approximately 14-fold relatively little chlorophyll....
Previous studies have suggested that lipid from nuts is more poorly absorbed than other food sources. If absorbed, then the metabolisable energy contained in less predicted by Atwater general factors. A crossover feeding study was conducted which sixteen volunteers consumed pistachios for 3 weeks as part of a controlled diet. Pistachio doses were 0, 42 and 84 g/d. Urine faecal samples collected, urine, faeces diet analysed N, fat, total dietary fibre, ash combustible energy. Blood also...
The measured metabolizable energy (ME) of whole almonds has been shown to be less than predicted by Atwater factors. However, data are lacking on the effects processing (roasting, chopping or grinding) ME almonds. A 5-period randomized, crossover study in healthy individuals (n = 18) was conducted measure different forms (42 g per day), as part a controlled diet: whole, natural almonds; roasted chopped almond butter; and control (0 day). After 9 days adaptation each diet, participants...
Berries and other anthocyanin-rich treatments have prevented weight gain adiposity in rodent models of diet-induced obesity. Their efficacy may be explained by modulation energy substrate utilization. However, this effect has never been translated to humans. The objective study was evaluate the effects berry intake on use glucoregulation volunteers consuming a high-fat diet. Twenty-seven overweight or obese men were enrolled randomized, placebo-controlled crossover with two treatment...
Metabolism of a 73 mumol oral dose beta-carotene-d8 in olive oil was determined from plasma and retinol-d4 concentration-time curves an adult male. beta-Carotene-d8 concentrations serial were measured using high performance liquid chromatography (HPLC) gas chromatography-mass spectrometry (GC-MS), respectively. Plasma described by 5-term 3-term polyexponential equation, respectively, empirical description beta-carotene metabolism. A physiologic compartmental model metabolism also constructed...