Hannah D. Holscher

ORCID: 0000-0003-4918-2426
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About
Contact & Profiles
Research Areas
  • Gut microbiota and health
  • Diet and metabolism studies
  • Nutritional Studies and Diet
  • Nutrition, Genetics, and Disease
  • Gastrointestinal motility and disorders
  • Food composition and properties
  • Probiotics and Fermented Foods
  • Metabolomics and Mass Spectrometry Studies
  • Antioxidant Activity and Oxidative Stress
  • Microbial Metabolites in Food Biotechnology
  • Obesity, Physical Activity, Diet
  • Dietary Effects on Health
  • Nuts composition and effects
  • Digestive system and related health
  • Infant Nutrition and Health
  • Consumer Attitudes and Food Labeling
  • Plant Physiology and Cultivation Studies
  • Physical Activity and Health
  • Bee Products Chemical Analysis
  • Eating Disorders and Behaviors
  • Nutrition and Health in Aging
  • Pharmacology and Obesity Treatment
  • Breastfeeding Practices and Influences
  • Horticultural and Viticultural Research
  • Diet, Metabolism, and Disease

University of Illinois Urbana-Champaign
2016-2025

Goodwin College
2024

National Center for Supercomputing Applications
2020-2023

Tate & Lyle (United Kingdom)
2023

Urbana University
2015-2023

University of Illinois System
2016-2022

Office of Dietary Supplements
2021

Intertek (Canada)
2021

Food & Nutrition
2021

Nutrition Sciences (Belgium)
2021

Exercise is associated with altered gut microbial composition, but studies have not investigated whether the microbiota and metabolites are modulated by exercise training in humans. We explored impact of 6 wk endurance on functional capacity, metabolic output lean obese adults multiple-day dietary controls before outcome variable collection.Thirty-two (n = 18 [9 female]) 14 [11 female]), previously sedentary subjects participated supervised, endurance-based (3 d·wk) that progressed from 30...

10.1249/mss.0000000000001495 article EN Medicine & Science in Sports & Exercise 2017-11-21

Prebiotics resist digestion, providing fermentable substrates for select gastrointestinal bacteria associated with health and well-being. Agave inulin differs from other type fibers in chemical structure botanical origin. Preclinical animal research suggests these differences affect bacterial utilization physiologic outcomes. Thus, is needed to determine whether effects translate healthy adults.We evaluated agave by the microbiota measuring fecal fermentative end products taxa.A randomized,...

10.3945/jn.115.217331 article EN publisher-specific-oa Journal of Nutrition 2015-07-23

Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer heart disease. Although there is accumulating preclinical evidence walnuts beneficially affect the gastrointestinal microbiota gut metabolic health, these relations not been investigated humans.We aimed to assess impact of walnut consumption on human markers health.A controlled-feeding, randomized crossover study was undertaken healthy men women...

10.1093/jn/nxy004 article EN cc-by-nc Journal of Nutrition 2018-01-26

Background: Almond processing has been shown to differentially impact metabolizable energy; however, the effect of food form on gastrointestinal microbiota is under-investigated. Objective: We aimed assess interrelationship almond consumption and microbiota. Design: A controlled-feeding, randomized, five-period, crossover study with washouts between diet periods was conducted in healthy adults (n = 18). Treatments included: (1) zero servings/day almonds (control); (2) 1.5 servings (42 g)/day...

10.3390/nu10020126 article EN Nutrients 2018-01-26

ABSTRACT Objectives: Human milk oligosaccharides (HMOs) are reported to promote epithelial cell differentiation in vitro. The aim of the present study was assess induction by individual and combined administration 3 HMOs. Methods: An vitro model crypt‐villus axis consisting preconfluent HT‐29, Caco‐2Bbe, postconfluent Caco‐2Bbe cells used. Cultures were randomized 17 treatments for 72 hours incubation: low‐ high‐dose HMOs (3′sialyllactose [3′SL] at 0.2 1.0 g/L, 6′siallylactose [6′SL] 0.4...

10.1097/mpg.0000000000001274 article EN Journal of Pediatric Gastroenterology and Nutrition 2016-06-02

Objective: Habitual diet impacts mood and the human gastrointestinal (GI) microbiota. Yet, studies infrequently control for when evaluating associations between GI Accordingly, we aimed to investigate relationships among diet, microbiota, in adults without disorders by conducting a cross-sectional examination of dietary intake, subjective emotional state, fecal microbial taxa abundances.Methods: Adults (N = 133; 25–45 years age) physician-diagnosed were studied. Fecal DNA was extracted, V4...

10.1080/1028415x.2019.1582578 article EN Nutritional Neuroscience 2019-02-22

Due to highly personalized biological and lifestyle characteristics, different individuals may have metabolite responses specific foods nutrients. In particular, the gut microbiota, a collection of trillions microorganisms living in gastrointestinal tract, is plays key role Accurately predicting dietary interventions based on individuals' microbial compositions holds great promise for precision nutrition. Existing prediction methods are typically limited traditional machine learning models....

10.1038/s41467-025-56165-6 article EN cc-by-nc-nd Nature Communications 2025-01-18

Background : Addition of probiotics to infant formula may positively affect immune function in nonexclusively breastfed infants. This study aimed investigate the effect starter containing probiotic Bifidobacterium animalis subspecies lactis (Bb12) on intestinal immunity and inflammation. Methods Six‐week‐old healthy, full‐term infants (n = 172) were enrolled a prospective, randomized, double‐blind, controlled clinical trial with 2 groups studied parallel comparison group. Formula‐fed (FF)...

10.1177/0148607111430817 article EN Journal of Parenteral and Enteral Nutrition 2012-01-01

Background : Prebiotic‐containing infant formula may beneficially affect gastrointestinal tolerance and commensal microbiota composition. Objective Assess fecal microbiota, pH, short‐chain fatty acid (SCFA) concentrations of infants consuming with or without prebiotics. Design Full‐term formula‐fed were studied to a breastfed comparison group (BF). Formula‐fed (FF) randomized consume partially hydrolyzed whey (PRE) (CON) 4 g/L galacto‐oligosaccharides fructo‐oligosaccharides (9:1). Fecal...

10.1177/0148607111430087 article EN Journal of Parenteral and Enteral Nutrition 2012-01-01

The gut microbiota is considered a relevant factor in obesity and associated metabolic diseases, for which postmenopausal women are particularly at risk. Increasing physical activity has been recognized as an efficacious approach to prevent or treat obesity, yet the impact of on remains under-investigated. We examined impacts voluntary exercise host metabolism ovariectomized (OVX) high capacity (HCR) low running (LCR) rats. HCR LCR rats (age = 27wk) were OVX fed high-fat diet (45% kcal fat)...

10.1371/journal.pone.0136150 article EN cc-by PLoS ONE 2015-08-24
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