A5077604751- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Photovoltaic System Optimization Techniques
- Circadian rhythm and melatonin
- Acute Myeloid Leukemia Research
- European and International Contract Law
- Cancer Mechanisms and Therapy
- Mechanical Engineering and Vibrations Research
- Silk-based biomaterials and applications
- Glass properties and applications
- Bacterial Genetics and Biotechnology
- Multiple Myeloma Research and Treatments
Rockefeller University
2016-2024
Heidelberg University
2014
University Hospital Heidelberg
2014
Massachusetts Institute of Technology
2007-2012
Allen Institute
2010-2012
Center for Cancer Research
2008
Institut thématique Génétique, génomique et bioinformatique
2003
Yale University
2002
Lawrence Livermore National Laboratory
1998
Wright State University
1978
Many microRNAs (miRNAs) target mRNAs involved in processes aberrant tumorigenesis, such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has been proposed to function tumor suppression, because reduced expression of members is common non-small cell lung cancer (NSCLC). Here, we show that functionally inhibits development. Ectopic let-7g K-Ras(G12D)-expressing murine cells induced both cycle arrest death. xenografts, observed significant growth reduction...
Riboswitches are metabolite-responsive genetic control elements that reside in the untranslated regions (UTRs) of certain messenger RNAs. Herein, we report 5′-UTR lysC gene Bacillus subtilis carries a conserved RNA element serves as lysine-responsive riboswitch. The ligand-binding domain riboswitch binds to L-lysine with an apparent dissociation constant (K D ) ∼1 µM, and exhibits high level molecular discrimination against closely related analogs, including D-lysine ornithine. Furthermore,...
Male/hermaphrodite species have arisen multiple times from a male/female ancestral state in nematodes, providing model to study behavioral adaptations different reproductive strategies. Here, we examined the mating behaviors of (gonochoristic) Caenorhabditis comparison with male/hermaphrodite (androdiecious) close relatives. We find that females two Elegans group chemotax volatile odor males, but hermaphrodites do not. Females, not hermaphrodites, also display known mating-receptive such as...
Oxytocin/vasopressin-related neuropeptides are highly conserved and play major roles in regulating social behavior across vertebrates. However, whether their insect orthologue, inotocin, regulates the of groups remains unknown. Here, we show that clonal raider ant Ooceraea biroi, individuals perform tasks outside nest have higher levels inotocin brains than same age remain inside nest. We also older ants, which spend more time nest, younger ants. Inotocin thus correlates with propensity to...
SUMMARY Information flow through neural circuits is continuously modified by context-dependent learning. In the nematode Caenorhabditis elegans, pairing specific odors with food deprivation results in aversion to odor. Here we identify cell-specific mechanisms of insulin/IGF receptor signaling that integrate sensory information context during aversive olfactory Using a conditional allele DAF-2, show learning butanone, an odor sensed only AWC ON neuron, requires DAF-2 . Learning...
Einleitung: Ein divergentes Ansprechen von Krebszellen auf Chemotherapeutika wird häufig beobachtet, die zugrunde liegenden molekularen Mechanismen sind jedoch oft unbekannt. Das CRISPR/Cas9 System ist ein neuartiges genetisches Werkzeug, das eine schnelle Generierung Gen-Knockouts ermöglicht.
Summary Male/hermaphrodite species have arisen multiple times from a male/female ancestral state in nematodes, providing model to study behavioral adaptations different reproductive strategies. Here we examined the mating behaviors of (gonochoristic) Caenorhabditis comparison male/hermaphrodite (androdiecious) close relatives. We find that females two Elegans group chemotax volatile odor males, behavior described only few animal species. The also display known mating-receptive such as...