A5001094927- Organophosphorus compounds synthesis
- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- Tribology and Lubrication Engineering
- Magnetic Bearings and Levitation Dynamics
- Chemical synthesis and alkaloids
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Molecular Sensors and Ion Detection
- Phosphorus compounds and reactions
- Vibration and Dynamic Analysis
- Metal and Thin Film Mechanics
- Cyclopropane Reaction Mechanisms
- Organoselenium and organotellurium chemistry
- Alzheimer's disease research and treatments
- Protein Kinase Regulation and GTPase Signaling
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Supramolecular Self-Assembly in Materials
- Synthesis of Organic Compounds
- RNA and protein synthesis mechanisms
- Catalytic C–H Functionalization Methods
- Computational Drug Discovery Methods
Pohang University of Science and Technology
1999-2007
Korea Advanced Institute of Science and Technology
1993-2005
University of Massachusetts Chan Medical School
2005
University of Pennsylvania
2001-2003
Ewha Womans University
2003
Centre for Addiction and Mental Health
2002
University of Toronto
2002
Yeungnam University
2001
University of Alabama
1999
National Heart Lung and Blood Institute
1993
We report the synthesis of single-crystalline silver nanowires atomic dimensions. The ultrathin wires with 0.4 nanometer width grow up to micrometer-scale length inside pores self-assembled calix[4]hydroquinone nanotubes by electro-/photochemical redox reaction in an ambient aqueous phase. present subnanowires are very stable under air and environments, unlike previously reported metal approximately 1 diameter, which existed only transiently ultrahigh vacuum. exist as coherently oriented...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSelf-Assembled Arrays of Organic Nanotubes with Infinitely Long One-Dimensional H-Bond ChainsByung Hee Hong, Jin Yong Lee, Chi-Wan Jong Chan Kim, Sung Chul Bae, and Kwang S. KimView Author Information National Creative Research Initiative Center for Superfunctional Materials Department Chemistry Division Molecular Life Sciences Pohang University Science Technology 790-784, Korea Cite this: J. Am. Chem. Soc. 2001, 123, 43,...
Abstract Six mammalian phospholipase C isozymes (PLC-beta 1, PLC-beta 2, PLC-gamma PLC-delta and 2) have been identified at both protein DNA levels. Here, cDNAs corresponding to a previously unidentified PLC isozyme were isolated from rat thyroid cell FRTL cDNA library. Comparison of the predicted amino acid sequence this new with other known revealed high degree overall similarity 1 2. Thus, was named 3. 2 also that deduced amino-terminal 3 incomplete by 10-20 acids. With use antibodies...
A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) bromo derivative competed 2-(4'-dimethylaminophenyl)-6-iodobenzothiazole, [125I]7(TZDM), a known ligand for aggregates, high affinities (Ki = 15 10 nM, respectively). In autoradiography brain sections transgenic mouse (Tg2576) [125I]16(IMPY)...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel Stilbenes as Probes for Amyloid PlaquesHank F. Kung, Chi-Wan Lee, Zhi-Ping Zhuang, Mei-Ping Catherine Hou, and Karl PlösslView Author Information Departments of Radiology Pharmacology University Pennsylvania, Room 305 3700 Market Street, Philadelphia, Pennsylvania 19104 Cite this: J. Am. Chem. Soc. 2001, 123, 50, 12740–12741Publication Date (Web):November 21, 2001Publication History Received26 July 2001Published online21 November...
The 150-kDa phospholipase C (PLC)-beta 1 and three immunologically related proteins with molecular sizes of 140, 100, 45 kDa were purified from bovine brain extracts. Determination the amino-terminal amino acid sequence 45-kDa protein immunoblots sequence-specific antibodies to peptides corresponding different regions PLC-beta suggest that a single cleavage at linkage between residues 880 881 generates 100- proteins, which correspond carboxyl-terminal portions, respectively, 1....
A benzene-based tripodal imidazolium receptor utilizing the strong (C-H)(+)...X(-) hydrogen bonding interaction between moieties and halide anions is extensively investigated both theoretically experimentally. Ab initio calculations predict that this has a very high affinity for fluoride ion (F(-)). The association constant free energy gain of N-butyl 2 F(-) in acetonitrile were measured to be 2.1 x 10(5) M(-1) -7.25 kcal/mol, respectively, showing highly polar organic solvents.
We have characterized inositol phospholipid-specific phospholipase C (PLC) isozymes in bovine retina. Chromatography of a retinal homogenate on heparin column partially resolved six peaks PLC activity, which differed their relative selectivities for the substrates phosphatidyl 4,5-bisphosphate (PIP2) and phosphatidylinositol (PI). Five were shown to correspond known PLC-beta 1, 3, PLC-gamma PLC-delta 2. 1 fractions identified by immunoblotting with isozyme-specific antibodies, 2 was direct...
Using the computer-aided molecular design approach, we recently reported synthesis of calix[4]hydroquinone (CHQ) nanotube arrays self-assembled with infinitely long one-dimensional (1-D) short hydrogen bonds (H-bonds) and aromatic−aromatic interactions. Here, assess various calculation methods employed for both CHQ nanotubes study their assembly process. Our calculations include ab initio density functional theories first principles using ultrasoft pseudopotential plane wave methods. The...
[formula: see text] A novel type of palladium-catalyzed cascade cyclization-coupling reaction that proceeds with suppressed beta-hydride elimination has been found. One the N-sulfonyl oxygens is suggested to coordinatively stabilize an alkylpalladium intermediate, thus preventing intermediate from usual beta-elimination. This first sequential coupling where Suzuki and Heck reactions can compete. The provides efficient synthetic route 4-methylene-3-arylmethylpyrrolidines, which are not...
Given the recent report of a novel pyrazole receptor exhibiting high selectivity for NH4+ over K+, it would be interesting to investigate origin this and affinity so that better receptors could designed. On basis extensive theoretical studies, we conclude arises from subtle interplay charged H-bonds cation−π interactions. The approach employed herein very useful in rational design functional molecular systems.
Reactions of the lithio anions derived from diethyl aklyphosphonates 1 with benzenetellurenyl iodide 5 give 1-(phenyltelluro)alkylphosphonates 2. Diethyl (alkyltelluromethyl)phosphonates 4 are prepared by treatment lithium tellurolates 3 iodomethylphosphonates 6. (Phenyltelluromethyl)phosphonate and NaH reacted aldehydes to produce vinyl tellurides 7.
A new molecular system, 2,11-dithio[4,4]metametaquinocyclophane containing a quinone moiety, was designed and synthesized. As the moiety can readily be converted into an aromatic π-system (hydroquinone) upon reduction, nanomechanical cyclophane system exhibits large flapping motion like flipper from electrochemical redox process. The conformational changes reduction oxidation are caused by of nonbonding interaction forces (devoid bond formation/breaking) edge-to-face to face-to-face...
A new, accelerated design scheme for photoinitiators based on an advanced machine learning framework is studied. Design space set by over 120 unique oxime ester compounds synthesized and measured their photosensitivity. Then, automated algorithm used rapidly identifying the best quantitative structure–property relationship (QSPR) models among hundreds that are generated, ranked, validated in fashion to predict Top-performing highly predictive with coefficients of determination around 0.8...
In developing probes for detecting β-amyloid (Aβ) plaques in the brain of Alzheimer's disease (AD), we have synthesized 1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (5, BSB). Due to presence two double bonds, formation four different isomers is possible. Four isomers, E,E-5, E,Z-5, Z,E-5, and Z,Z-5, were prepared. Surprisingly, all showed strong fluorescent labeling Aβ postmortem sections patients with confirmed AD. vitro binding assay also that BSB (E,E-5, Z,Z-5) displayed a...
In consideration of competition between cation-π and hydrogen bond interaction forces, we designed a novel receptor, 1,3,5-tris(pyrrolyl)benzene, which shows high selectivity for acetylcholine (ACh). The the receptor ACh over other ammonium cations is demonstrated by ion-selective electrode (ISE) method in buffer solution. binding free energy with chloroform solution measured to be 3.65 kcal/mol presence chloride anion nuclear magnetic resonance spectroscopy, that water estimated much...
A feasible fabrication technique for nanomachines that are based on carbon nanotubes (CNTs) is demonstrated. Direct nanowiring of CNTs between micrometer islands reported to have been achieved by a growth barrier technique, which prevents vertical the CNTs, i.e., towards substrate. The result “straight” or “Y-shaped” CNT bridges predefined electrodes (see Figure).
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of 4-Oxo-2-alkenylphosphonates via Nitrile Oxide Cycloaddition: γ-Acylation Allylic PhosphonatesShi Yong Lee, Bum Sung Chi-Wan and Dong Young OhView Author Information Department Chemistry, Korea Advanced Institute Science Technology, 373-1, Kusong-dong, Yusong-gu, Taejon, 305-701, Cite this: J. Org. Chem. 2000, 65, 1, 256–257Publication Date (Web):December 15, 1999Publication History Received9 August 1999Published online15 December inissue...