A5098731861- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
University of California, Davis
2024-2025
Embryonic exposures to non-steroidal anti-inflammatory drugs (NSAIDs) have been linked preterm birth, neural tube closure defects, abnormal enteric innervation, and craniofacial malformations, potentially due disrupted or crest (NC) cell development. Naproxen (NPX), a common drug (NSAID) used relieve pain inflammation, exerts its effects through non-selective cyclooxygenase (COX) inhibition. Our lab has identified that the (COX-1 COX-2) isoenzymes are expressed during early stages of...
Abstract Vertebrate development is regulated by several complex well-characterized morphogen signaling pathways, transcription factors, and structural proteins, but less known about the enzymatic pathways that regulate early development. We have identified factors from inflammation-mediating cyclooxygenase (COX) pathway are expressed at stages of in avian embryos. Using Gallus gallus (chicken) as a research model, we characterized spatiotemporal expression subset genes proteins COX during...
The domestic cat (Felis catus) is a valued companion animal and model for virally induced cancers immunodeficiencies. However, species-specific limitations such as scarcity of immune cell markers constrain our ability to resolve subsets at sufficient detail. goal this study was characterize circulating feline T cells other leukocytes based on their transcriptomic landscape T-cell receptor repertoire using single RNA-sequencing.
Our lab has identified that transcripts and proteins of the cyclooxygenase (COX-1 COX-2) isoenzymes are expressed during early stages vertebrate embryonic development, global COX-1/2 inhibition disrupts neural crest (NC) cell maturation in
Introduction The domestic cat (Felis catus) is a valued companion animal and model for virally induced cancers immunodeficiencies. However, species-specific limitations such as scarcity of immune cell markers constrain our ability to resolve subsets at sufficient detail. goal this study was characterize circulating feline T cells other leukocytes based on their transcriptomic landscape T-cell receptor repertoire using single RNA-sequencing. Methods Peripheral blood from 4 healthy cats...