A5081509419- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
Heinrich Heine University Düsseldorf
2021-2024
Deutsches Diabetes-Zentrum e.V.
2021-2024
German Center for Diabetes Research
2021-2024
Helmholtz Zentrum München
2021
Abstract Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood flow initiates liver growth in mice by vasodilation and mechanically-triggered release of angiocrine signals. Here, use mass spectrometry to identify a mechanically-induced signal human endothelial cells, is, myeloid-derived factor (MYDGF). We show it induces proliferation promotes survival primary hepatocytes derived from different donors two-dimensional cell culture, via activation...