A5086670534- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Advanced Memory and Neural Computing
- Medicinal Plants and Neuroprotection
- Ion channel regulation and function
- Neuroscience of respiration and sleep
- Erythrocyte Function and Pathophysiology
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
University of Alabama at Birmingham
2018-2021
Duke-NUS Medical School
2017
National University of Singapore
2015
Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson's Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, up to 80% PD patients develop dementia. α-Syn are abundant in the hippocampus, yet functional consequences unclear. To determine if pathologic α-syn causes neuronal defects, we induced endogenous form resembling those found diseased brains by treating hippocampal neurons fibrils. At seven days after adding fibrils, axons, but there...
The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates reliability transmission. Variability this fundamental property provides diversity function across brain regions, but source variability is unclear. prevailing view that release a single (univesicular release, UVR) or multiple (multivesicular MVR) reflects in vesicle probability, notion well-supported by calcium-dependence mode. However, using mouse slices, we now demonstrate...
The ability to process complex spatiotemporal information is a fundamental underlying the behavior of all higher organisms. However, how brain processes in temporal domain remains incompletely understood. We have explored information-processing capability networks formed from dissociated rat E18 cortical neurons growing culture. By combining optogenetics with microelectrode array recording, we show that these randomly organized microcircuits are able information, allowing identification...
Bacopa monnieri is a plant used as nootropic in Ayurveda, 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role memory enhancer, the molecular cellular mechanism underlying Bacopa's action are not understood. In this study, we deep sequencing (RNA-Seq) to identify transcriptome changes upon treatment on SH-SY5Y human neuroblastoma cells. We identified several genes whose expression levels were regulated by Bacopa. Biostatistical...
Neurotransmitter spillover is a form of communication not readily predicted by anatomic structure. In the cerebellum, glutamate from climbing fibers recruits molecular layer interneurons in absence conventional synaptic connections. Spillover-mediated signaling typically limited transporters that bind and reuptake glutamate. Here, we show patterned expression excitatory amino acid transporter 4 (EAAT4) Purkinje cells regulates to interneurons. Using male female Aldolase C-Venus knock-in mice...