A5073327768- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Pericarditis and Cardiac Tamponade
- Atrial Fibrillation Management and Outcomes
- Gestational Trophoblastic Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Blood properties and coagulation
- Nanocluster Synthesis and Applications
- Blood Coagulation and Thrombosis Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Atherosclerosis and Cardiovascular Diseases
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Cardiac Imaging and Diagnostics
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Extracellular vesicles in disease
Shanghai Jiao Tong University
2015-2023
Shanghai Sixth People's Hospital
2022-2023
Atherosclerosis with unstable plaques is the dominant pathological basis of lethal cardio-cerebrovascular diseases, which can cause acute death due to rupture plaques. Plaque-targeted drug delivery achieve promoted treatment remains main challenge because systemic occurrence atheroma. Herein, a rapamycin (RAP) spherical nucleic acid (SNA) structure, capable specifically accumulating in for synergistic atherosclerosis constructed. By designing consecutive phosphorothioate (PS) at 3' terminus...
(1) Background: Acute ischemic stroke (IS) is one of the main causes human disability and death. Therefore, multifunctional nanosystems that effectively cross blood-brain barrier (BBB) efficiently eliminate reactive oxygen species (ROS) are urgently needed for comprehensive neuroprotective effects. (2) Methods: We designed a targeted transferrin (Tf)-based manganese dioxide nanozyme (MnO2@Tf, MT) using mild biomimetic mineralization method rebalancing ROS levels. Furthermore, MT can be...
uPA is loaded on BPNs as a nanodrug. can be delivered firstly for thrombus dissolution. Secondly, the residual after release cross BBB with assistance of 808 nm laser irradiation and eliminate reactive oxygen species.
Abstract The development of a fibrinolytic system with long circulation time, high thrombus targeting, efficient penetration, effective thrombolysis, and minimal hemorrhagic risk remains major challenge. Herein, inspired by fibrinogen binding to activated platelets in thrombosis, this article reports fibrinogen‐mimicking, activated‐platelet‐sensitive nanocoacervate enhance penetration tissue plasminogen activator (tPA) for targeted thrombolytic therapy. This biomimetic nanothrombolytic...