A5027144941- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Immune cells in cancer
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
University of Bern
2018-2023
Federal Department of Home Affairs
2019
PEDV is a swine pathogen that responsible for significant animal and economic losses worldwide. Highly pathogenic variants can lead to mortality rate of up 100% in newborn piglets.
Porcine reproductive and respiratory syndrome virus (PRRSV) represents a macrophage (MØ)-tropic which is unable to induce interferon (IFN) type I in its target cells. Nevertheless, infected pigs show short but prominent systemic IFN alpha (IFN-α) response. A possible explanation for this discrepancy the ability of plasmacytoid dendritic cells (pDC) produce IFN-α response free PRRSV virions, independent infection. Here we that highly pathogenic genotype 1 strain Lena unique not inducing...
Vaccination is one of the most important tools to protect pigs against infection with porcine reproductive and respiratory syndrome virus 1 (PRRSV-1). Although neutralizing antibodies are considered represent an mechanism protective immunity, anti-PRRSV antibodies, in particular at subneutralizing concentrations, have also been reported exacerbate PRRSV infection, probably through FcγR-mediated uptake antibody-opsonized PRRSV, resulting enhanced of, replication in, target cells. Therefore,...