A5002616579- Marine Sponges and Natural Products
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Parasite Biology and Host Interactions
- Helminth infection and control
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Parasites and Host Interactions
- Bioactive Compounds and Antitumor Agents
- Traditional and Medicinal Uses of Annonaceae
- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
- Piperaceae Chemical and Biological Studies
- Phytochemical compounds biological activities
Griffith University
2019-2024
There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes veterinary importance circumvent challenges linked drug resistant parasites. Being one most diverse natural ecosystems, marine environment represents a rich resource novel chemical entities. This study investigated 2000 extracts from invertebrates, collected Australian waters, anthelmintic activity. Using well-established in vitro bioassay, these were screened nematocidal activity...
Due to the widespread occurrence and spread of anthelmintic resistance, there is a need develop new drugs against resistant parasitic nematodes livestock animals. The Nobel Prize-winning discovery development anti-parasitic avermectin artemisinin has renewed interest in exploring natural products as anthelmintics. In present study, we screened 7500 plant extracts for vitro-activity barber's pole worm, Haemonchus contortus, highly significant pathogen ruminants. from two plants, Cryptocarya...
Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs demands the discovery and development novel compounds with distinct mechanisms action complement strategic or integrated parasite control programs. Products from nature-which assume a diverse 'chemical space'-have significant potential as source compounds. In present study, we screened collection extracts (
Chemical investigations of two specimens the Australian crinoid Comatula rotalaria afforded five new taurine-conjugated anthraquinones, comatulins A-E (1-5), together with 11 known marine natural products (6-16). The chemical structures all compounds were elucidated by detailed spectroscopic and spectrometric data analysis. first X-ray crystal structure a crinoid-derived acyl anthraquinone, rhodocomatulin 5,7-dimethyl ether (8), is reported here. Compounds 1, 2, 6-13, additional...
In order to further expand the NatureBank open access compound library, chemical investigations of Australian marine sponge, Ianthella basta, were undertaken since UHPLC–MS analysis extract from this sponge indicated presence a new alkaloid. Large-scale extraction and mass-directed isolation studies on CH 2 Cl /MeOH I. basta resulted in purification bromotyrosine-derived alkaloid, 5-debromopurealidin H ( 1 ), along with known natural product, ianthesine E ). The structure was determined...
High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for parasitic nematode Haemonchus contortus identified an active derived from Australian sponge Citronia sp. Bioassay-guided fractionation CH2Cl2/MeOH resulted in purification two known hexachlorinated peptides, dysidenin (1) and dysideathiazole (2). Compound 1 inhibited growth/development H. larvae induced multiple changes, including lethal evisceration (Evi) phenotype and/or somatic cell...
Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and offer effective additive therapeutic options. High-throughput screening subset NatureBank marine fraction library (n = 2000) identified sample derived from Australian sponge belonging order Haplosclerida that displayed promising anti-mycobacterial activity. Bioassay-guided fractionation organic extract this led purification...
The marine sponge