A5081410662- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Neurobiology and Insect Physiology Research
- Colorectal Cancer Screening and Detection
- Burkholderia infections and melioidosis
- Photochromic and Fluorescence Chemistry
- 3D Printing in Biomedical Research
- Axon Guidance and Neuronal Signaling
- Arctic and Antarctic ice dynamics
- Pickering emulsions and particle stabilization
- Pineapple and bromelain studies
- Microbial Metabolites in Food Biotechnology
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- RNA Interference and Gene Delivery
- Bacterial Infections and Vaccines
- Gastric Cancer Management and Outcomes
- Global Financial Crisis and Policies
- Genetic factors in colorectal cancer
- Electrospun Nanofibers in Biomedical Applications
- Biochemical and Structural Characterization
- Spacecraft and Cryogenic Technologies
- Enzyme Production and Characterization
Griffith University
2015-2024
The University of Melbourne
1993-2023
Cancer Council Victoria
2016-2023
The Royal Melbourne Hospital
1994-2023
Sathyabama Institute of Science and Technology
2023
AgriBio
2022
Christie's
2020-2021
The Ohio State University Newark
2010-2019
Great Ormond Street Hospital
2018
University College London
2018
Three-dimensional (3D) printing of human tissues and organ has been an exciting research topic in the past three decades. However, existing technological biological challenges still require a significant amount research. The present review highlights these discusses their potential solutions such as mapping converting onto 3D virtual design, synchronizing design with hardware. Moreover, paper details recent advances formulating bio-inks tissue construction or without scaffold. Next, reviews...
Abstract We describe a novel protocol for three-dimensional culturing of olfactory ensheathing cells (OECs), which can be used to understand how OECs interact with other in three dimensions. Transplantation is being trialled repair the paralysed spinal cord, promising but variable results and thus therapy needs improving. To date, studies OEC behaviour multicellular environment have been hampered by lack suitable cell culture models. Here, we exploit floating liquid marble, droplet coated...
We report a digital microfluidics platform based on floating liquid marbles.
Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, link between C. CNS infection and late-onset dementia has become increasingly evident. In mice, been shown to occur weeks months after intranasal inoculation. By isolating live from tissues using immunohistochemistry, we show that olfactory trigeminal nerves, bulb brain within 72 h in mice. resulted dysregulation of key pathways involved Alzheimer's disease pathogenesis at 7...
ABSTRACT During development of the primary olfactory system, axon targeting is inaccurate and axons inappropriately project within target layer or overproject into deeper layers bulb. As a consequence there considerable apoptosis neurons during embryonic postnatal degraded need to be removed. Olfactory ensheathing cells (OECs) are glia nerve known phagocytose debris in adult animal. However, it unclear when phagocytosis by OECs first commences. We investigated onset developing mouse system...
ABSTRACT Melioidosis is a potentially fatal disease that endemic to tropical northern Australia and Southeast Asia, with mortality rate of 14 50%. The bacterium Burkholderia pseudomallei the causative agent which infects numerous parts human body, including brain, results in neurological manifestation melioidosis. olfactory nerve constitutes direct conduit from nasal cavity into we have previously reported B. can colonize this mice. We now investigated detail mechanism by bacteria penetrate...
Abstract Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches neural regeneration due to their ability assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed waves, integral OEC migration. Time‐lapse imaging migrating OECs revealed highly dynamic waves progress along shaft crucial mediating cell–cell...
Summary Kallmann's syndrome is caused by the failure of olfactory axons and gonadotropin-releasing hormone (GnRH) neurons to enter embryonic forebrain, resulting in anosmia sterility. Sox10 mutations have been associated with phenotypes, but their effect on system development unknown. We recently showed that expressed neural crest-derived ensheathing cells (OECs). Here, we demonstrate homozygous Sox10lacZ/lacZ mouse embryos, OEC differentiation disrupted; accumulate ventromedial nerve layer...
Objectives: Malignant tumors of the paranasal sinuses are traditionally approached by a variety external incisions. Recent advances in endoscopic endonasal surgery have allowed for some these to be treated endoscopically. The purpose this study was assess outcomes and complications approach series patients with sinus malignancies. Methods: A retrospective chart review performed sinonasal or skull base malignancies endoscopic-assisted resections at tertiary care institution from 2002 2010....
One of the promising strategies for neural repair therapies is transplantation olfactory ensheathing cells (OECs) which are glial system. We evaluated effects curcumin on behaviour mouse OECs to determine if it could be use further enhance therapeutic potential OECs. Curcumin, a natural polyphenol compound found in spice turmeric, known its anti-cancer properties at doses over 10 µM, and often 50 exerts cancer part by activation MAP kinases. In contrast, we that low-dose (0.5 µM) applied...
We report carbon nanodots that can be utilized as effective color converting phosphors for the production of white light-emitting diodes (LEDs). Blue-excitable and yellow-emitting nanodots, functionalized with 3-(imidazolidin-2-on-1-yl)propylmethyldimethoxysilane (IPMDS)-derived moieties (IS-CDs), are synthesized by a novel one-pot reaction in which products from initial occurring between urea 3-(2-aminoethylamino)propylmethyl-dimethoxysilane (AEPMDS) further treated citric acid. Distinctive...
Flotation of small solid objects and liquid droplets on water is critical to natural industrial activities. This paper reports the floating mechanism marbles, or coated with hydrophobic microparticles. We used X-ray computed tomography (XCT) acquire cross-sectional images marble interface between different phases. then analysed shape angles at three-phase contact line (TPCL). found that marbles follow governing flotation in terms surface tension forces. However, formed deformation resemble a...
Summary Background Accurate definition of the gastroduodenal and ileocaecal junctions (GDJ, ICJ) is essential for measurement regional transit times. Aims To compare assessment these landmarks using novel gas‐sensing capsule validated wireless motility (WMC), to evaluate intra‐subject variance in times Methods Healthy subjects ingested WMC tandemly random order. Inter‐observer agreement was evaluated by intra‐class correlation coefficient (ICC). Agreement between paired devices' assessed...
We report the analytical and experimental characterisation of deformation a liquid marble floating on surface.