A5044284698- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Photochromic and Fluorescence Chemistry
- Regulation of Appetite and Obesity
- Burkholderia infections and melioidosis
- Spinal Cord Injury Research
- Diet and metabolism studies
- Mesenchymal stem cell research
- Gene expression and cancer classification
- Birth, Development, and Health
- Stress Responses and Cortisol
- Obesity and Health Practices
- Click Chemistry and Applications
- Advanced Biosensing Techniques and Applications
- Adipose Tissue and Metabolism
- Protein Degradation and Inhibitors
- Surgical Simulation and Training
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
Queensland University of Technology
2014-2024
Translational Research Institute
2019-2022
Griffith University
2008-2019
The University of Queensland
2006-2019
Queensland Health
2019
Zahedan University of Medical Sciences
2007-2008
ABSTRACT During development of the primary olfactory system, axon targeting is inaccurate and axons inappropriately project within target layer or overproject into deeper layers bulb. As a consequence there considerable apoptosis neurons during embryonic postnatal degraded need to be removed. Olfactory ensheathing cells (OECs) are glia nerve known phagocytose debris in adult animal. However, it unclear when phagocytosis by OECs first commences. We investigated onset developing mouse system...
Burkholderia pseudomallei, the causative agent of melioidosis, is generally considered to be acquired via inhalation dust or water droplets from environment. In this study, we show that infection nasal mucosa potentially an important portal entry in melioidosis.After intranasal inoculation mice, was monitored by bioluminescence imaging and immunohistological analysis coronal sections. The bacterial loads organ tissue specimens were also monitored.Bioluminescence showed colonization...
Sugar has become embedded in modern food and beverages. This led to overconsumption of sugar children, adolescents, adults, with more than 60 countries consuming four times (>100 g/person/day) the WHO recommendations (25 g/person/day). Recent evidence suggests that obesity impulsivity from poor dietary habits leads further processed The long-term effects on cognitive processes hyperactivity overconsumption, beginning at adolescence are not known. Using a well-validated mouse model...
Contextual fear conditioning is a Pavlovian paradigm capable of rapidly creating memories to contexts, such as rooms or chambers. protocols have long been utilised evaluate how are consolidated, maintained, expressed, recalled and extinguished within the brain. These studies identified lateral portion amygdala dorsal hippocampus essential for contextual memory consolidation. The current study was designed two different alter microglia, brain derived neurotrophic factor (BDNF), phosphorylated...
Inflammation of the spinal cord after traumatic injury (SCI) leads to destruction healthy tissue. This "secondary degeneration" is more damaging than initial physical damage and major contributor permanent loss functions. In our previous study, we showed that combined delivery two growth factors, vascular endothelial factor platelet-derived factor, significantly reduced secondary degeneration hemisection in rat. Growth treatment size lesion cavity at 30 days, compared control animals,...
The overconsumption of sugar-sweetened food and beverages underpins the current rise in obesity rates. Sugar induces maladaptive neuroplasticity to decrease dietary control. Although serotonin glutamate co-localisation has been implicated reward processing, it is still unknown how chronic sucrose consumption changes this transmission regions associated with executive control over feeding—such as prefrontal cortex (PFC) dentate gyrus (DG) hippocampus. To address this, a total 16 C57Bl6 mice...
Neuroscience offers important insights into the pathogenesis and treatment of obesity by investigating neural circuits underpinning appetite feeding. Gamma-aminobutyric acid (GABA), one most abundant neurotransmitters in brain, its associated receptors represent an array pharmacologically targetable mediators signalling. Targeting GABAergic system is therefore increasingly investigated approach to treatment. However, many projections that control feeding have yet be collectively analysed....
Olfactory ensheathing cells (OECs) support the regeneration of olfactory sensory neurons throughout life, however, it remains unclear how OECs respond to a major injury. We have examined proliferation and migration following unilateral bulbectomy in postnatal mice. S100ß-DsRed OMP-ZsGreen transgenic mice were used visualize neurons, respectively, we thymidine analogue ethynyl deoxyuridine (EdU) identify that proliferating at time administration. Following bulbectomy, there was an initial...
Neuroanatomy education benefits from cadaveric specimens, yet challenges with access, cost, and health concerns exist. Virtual Dissection Tables (VDTs) offer digital alternatives to traditional learning. This article evaluates the pedagogical value of VDTs in undergraduate neuroanatomy education. While VDTs, primarily Anatomage, interactive 3D images customization options, research on their impact learning outcomes remains limited. Existing studies suggest comparable knowledge retention...
The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within bulb. However, some factors such as head trauma skull base surgery damage nerve which lead dysfunction. Losing sense of smell has considerable effects on quality life life-expectancy. Therefore, there is clear need find treatment for One potential growth factor therapy showed promising results in spinal...
Axon targeting during the development of olfactory system is not always accurate, and numerous axons overextend past target layer into deeper layers bulb. To date, fate mis-targeted has been determined. We hypothesized that following overextension, degenerate, cells within bulb phagocytose axonal debris. utilized a line transgenic mice expresses ZsGreen fluorescent protein in primary axons. found overextending closely followed filaments radial glia present embryonic development. Following...
Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder. Pavlovian fear conditioning protocols have long been utilised to manipulate study these disorders. Contextual (CFC) particular procedure that pairs with context. Studies on the neural mechanisms underlying development of contextual memories identified medial prefrontal cortex (mPFC), or more specifically, pre-limbic (PL) mPFC as essential for expression fear. Despite this, little research has explored...