A5089060117- High Altitude and Hypoxia
- Spaceflight effects on biology
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Ion channel regulation and function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thermoregulation and physiological responses
- Extracellular vesicles in disease
- Muscle metabolism and nutrition
- Frailty in Older Adults
- Heme Oxygenase-1 and Carbon Monoxide
- Salivary Gland Disorders and Functions
- Thermal Regulation in Medicine
- Consumer Attitudes and Food Labeling
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Growth Hormone and Insulin-like Growth Factors
- Health, Environment, Cognitive Aging
- Color perception and design
- Dietary Effects on Health
- Viral Infections and Vectors
- Vitamin D Research Studies
- Effects and risks of endocrine disrupting chemicals
- Digestive system and related health
- Neonatal Health and Biochemistry
University of Chieti-Pescara
2021-2024
University of Perugia
2024
Università Campus Bio-Medico
2021
Exposure to high altitude might cause the body adapt with negative energy and fluid balance that compromise composition physical performance. In this field study involving 12 healthy adults, sex-balanced, aged 29 ± 4 years a mass index of 21.6 1.8 kg/m
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a demanding medical condition for patients and society. It has raised much more public awareness after the COVID‐19 pandemic since ME/CFS long‐COVID share many clinical symptoms such as debilitating chronic fatigue. However, unlike long COVID, etiopathology of remains mystery despite several decades' research. This review moves from pathophysiology through compelling evidence most interesting hypotheses. focuses on...
Abstract Extracellular vesicles (EVs) enriched with bioactive molecules have gained considerable attention in nanotechnology because they are critical to intercellular communication while maintaining low immunological impact. Among biological matrices, urine has emerged as a noninvasive source of extracellular-contained liquid biopsy, currently interest readout for physiological adaptations. Therefore, we aimed evaluate chronic adaptations endurance sport practice terms urinary EV parameters...
Phthalates are chemical compounds, mainly used as additives in plastics, which known to induce harmful impacts the environment and human health due their ability act hormone-mimics. Few studies have been reported on relationship between exposure phthalates level of circulating microRNAs (miRs), especially those miRs encapsulated extracellular vesicles/exosomes or exosome-like vesicles (ELVs). We examined ELV-miR expression patterns urine adult men with five phthalate metabolites (i.e., mono...
Since the outbreak of SARS-CoV-2 pandemic in 2020, many governments have been imposing confinement and physical distancing measures. No data exist on effects lockdowns health status patients affected by chronic pathologies, specifically those with Chronic Obstructive Pulmonary Disease (COPD). Our study aims to establish variations across psychological cognitive profile during isolation period Italy, a cohort COPD, between February May 2020. Forty established COPD were comprehensively...
Background:Milk and dairy product intake are associated with higher IGF-1 concentrations, a well-known factor promoting adverse events such as carcinogenesis. Different associations high levels of IGF-I were found for protein milk derivatives, soy protein. In this contest, fermented (kefir)exhibits growing number health-promoting effects including stimulation the immune system, antimutagenic anticarcinogenic activity, but there is lack data on healthy humans. Objectives: We aimed to...
Since trips to high altitude have become popular, reports on clinical and environmental characteristics during expeditions popular destinations are needed.A group of 15 healthy adults was monitored a trek Capanna Margherita (4556 m). A hypoxic stress test applied before the expedition started. Environmental were acquired with portable device. Vital signs compared at low altitude, sickness diagnosed by Lake Louise scoring system. Ocular symptoms intraocular pressure recorded.Temperature...
High-altitude exposure leads to many physiological challenges, such as weight loss and dehydration. However, little attention has been posed the role of nutrition ethnic differences. Aiming fulfill this gap, five Italian trekkers seven Nepalese porters, all males, recorded their diet in diaries during a Himalayan expedition (19 days), average daily intake micro macro-nutrients were calculated. Bioimpedance analysis was performed times trek; muscle ultrasound before after expedition, only for...
Human postmortem skeletal muscles are a unique source of satellite cells for muscle regenerative studies. Presomite and somite obtained by have been established as populations human precursor able to proliferate differentiate in vitro. It is extremely interesting access large amount cells, especially from craniofacial well limb order evaluate their potential application not only the fundamental understanding physiology diseases but also drug testing challenging 3D-shaping like...
Reports of electromyography during hypoxic exercise are contrasting, due to protocol and muscle diversity. This work aimed investigate alterations in activation myoelectrical fatigue at high-altitude those muscles primarily involved trekking. Twelve young adults balanced by gender age were tested low (1,667 m) high (4,554 m, "Capanna Margherita", Italy) altitude, an isometric squat lasting 60 seconds. High-density surface was performed from the quadriceps right limb. The root mean square...
The present work aims to link the redox and cell-centric theories of chronic processes in human biology, focusing on aging. A synthetic overview cellular pathways will be integrated by concept hormesis, which disruption leads several physiopathological processes. onset age-related diseases due restriction homeodynamic capacity herein considered a fashion. Up-to-date arguments hormetic agents, such as geroprotectors, dietary interventions, physical exercise are refining presented theoretical...
Almond is a traditional food with established beneficial effects on health. Nothing known about the presence of extracellular vesicles (EVs), recently isolated from other plant material, ingested food, or as engineered bioactive nanovectors. Aiming to develop and optimize method isolate almonds derived nano (ADNVs), we tested different protocols pure, blanched roasted almonds, investigated resulting biophysical features. The most feasible valid was sucrose-based ultracentrifugation (DGUC)....
The environment can alter the homeostasis of humans and human microbiota. Oral health is influenced by high altitude through symptoms periodontitis, barodontalgia, dental barotrauma, a decrease in salivary flow. Microbiota inflammatory state are connected oral cavity. This study aimed to explore effect acute high-altitude exposure on microbiome indicators.
Humans exposed to altitude hypoxia experience dysfunctions of the urinary system. As a non-invasive, easily manageable and informative biological sample, urine represents relevant matrix for detecting clinical impairments system, as well alterations other systems extracellular vesicles (EVs) biology during high-altitude expeditions. Nevertheless, gaps exist in comprehensive assessment dysfunction, molecular burden EVs due acute exposure. This study aimed find biophysical biochemical...
Many skeletal muscle diseases such as muscular dystrophy, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and sarcopenia share the dysregulation of calcium (Ca2+) a key mechanism disease at cellular level. Cytosolic concentrations Ca2+ can signal in organelles including mitochondria, nucleus, sarcoplasmic reticulum muscle. In this work, treatment is applied to mimic increase associated with these atrophy-related states, broadband impedance measurements are taken for single cells...
To gain a deep insight and to obtain superior understanding about guanosine-based pathway, this paper reports an innovative approach study critical subject. Firstly, after exhaustive analysis of literature with focus in legal medicine extracellular vesicles, it was understood that new method is inevitable follow, determine, quantify these analytes (Guanosine monophosphate - GMP, guanosine diphosphate GDP, triphosphate GTP, Guanosine, Neopterin Tetrahydrobiopterin BH4). Starting from...