Lu-Chan Gong

ORCID: 0000-0002-9174-0033
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About
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Research Areas
  • Probiotics and Fermented Foods
  • GABA and Rice Research
  • Biochemical effects in animals
  • Bacterial biofilms and quorum sensing
  • Enzyme Production and Characterization
  • Diet and metabolism studies
  • Gut microbiota and health
  • Medicinal Plants and Neuroprotection
  • Phytochemical compounds biological activities
  • Bacteriophages and microbial interactions
  • Electrohydrodynamics and Fluid Dynamics
  • Moringa oleifera research and applications
  • Cholesterol and Lipid Metabolism
  • Biochemical Analysis and Sensing Techniques
  • Microbial Fuel Cells and Bioremediation
  • Lipid metabolism and biosynthesis
  • Fatty Acid Research and Health
  • Antimicrobial Peptides and Activities
  • Chemical synthesis and alkaloids
  • Protein purification and stability
  • Water Treatment and Disinfection
  • Algal biology and biofuel production
  • Bacterial Genetics and Biotechnology
  • Analytical Chemistry and Chromatography
  • Protein Hydrolysis and Bioactive Peptides

Jiangsu University of Science and Technology
2022-2024

Jiangnan University
2019-2024

Chinese Academy of Agricultural Sciences
2022-2024

Sericultural Research Institute
2022-2024

Ministry of Agriculture and Rural Affairs
2022-2024

Beijing Technology and Business University
2023

State Key Laboratory of Food Science and Technology
2019-2020

Dalian Polytechnic University
2013

In lactic acid bacteria (LAB), stress leads to decreases of cell vitality and fermentation yield. Glutamate decarboxylase (GAD) system is regarded as one the essential acid-resistance mechanisms in LAB. However, regulation GAD not well identified genus Lactobacillus. Although potential transcriptional regulator gene located upstream genes was found several Lactobacillus species, such (L.) brevis, contribution resistance has been experimentally determined. The gadR disrupted by homologous...

10.1186/s12934-019-1157-2 article EN cc-by Microbial Cell Factories 2019-06-13

A porous cellulose bioreactor with directional channels was prepared for flow catalysis. The hierarchical structure enhanced the mass transfer and improved catalytic efficiency.

10.1039/d2gc04016f article EN Green Chemistry 2023-01-01

The high cell density, immobilization and stability of biofilms are ideal characteristics for bacteria in resisting antibiotic therapy. CsgD is a transcription activating factor that regulates the synthesis curly fimbriae cellulose Escherichia coli, thereby enhancing bacterial adhesion promoting biofilm formation. To investigate role formation stress resistance bacteria, csgD deletion mutant ΔcsgD was successfully constructed from engineered strain E. coli BL21(DE3) using CRISPR/Cas9...

10.3390/ijms241813681 article EN International Journal of Molecular Sciences 2023-09-05

Free-living lactic acid bacteria often encounter stresses because of their organic acid-producing features. Several resistance mechanisms, such as the glutamate decarboxylase system, F 1 o -ATPase proton pump, and alkali production, are usually employed to relieve growth inhibition caused by acids. The system is vital for GAD-containing protect cells from DNA damage, enzyme inactivation, product yield loss in acidic habitats. In this study, we found that a MerR-type regulator, GlnR, was...

10.1128/aem.02615-19 article EN Applied and Environmental Microbiology 2020-01-17

Mulberries, known for their high sugar content and rich bioactive compounds, have attracted attention potential health benefits. γ-Aminobutyric acid (GABA) is an amino with multiple physiological functions. To increase the GABA enhance antioxidant capacity in fermented mulberry beverages, we screened a high-yielding strain, Lactobacillus brevis S3, its probiotic properties. L. S3 demonstrated excellent tolerance to simulated gastric acid, juice, intestinal fluid, bile salts, osmotic...

10.3390/fermentation9090829 article EN cc-by Fermentation 2023-09-11

Boron is an essential element for autoinducer-2 (AI-2) synthesis of quorum sensing (QS) system, which affects bacterial collective behavior. As a living biocatalyst, biofilms can stably catalyze the activity intracellular enzymes. However, it unclear how boron biofilm formation in E. coli, particularly recombinant coli with This study screened different derivatives to explore their effect on formation. The stress response was illuminated by analyzing AI-2 activity, extracellular polymeric...

10.3390/ijms23158059 article EN International Journal of Molecular Sciences 2022-07-22

γ-Aminobutyric acid (GABA) is a prevalent nonprotein amino with diverse physiological functions, attracting considerable interest in the food industry. However, current GABA-producing strains require glutamate as substrate for synthesis. Probiotics capable of de novo GABA synthesis using sugars without are crucial developing novel foods. This study employed pH indicator method to selectively screen bacteria. Nineteen fermentation liquid greater than 5 were obtained, all demonstrated ability...

10.1016/j.lwt.2024.116560 article EN cc-by-nc-nd LWT 2024-07-27

γ-Aminobutyric acid (GABA) is a ubiquitous nonprotein amino that has multiple physiological functions and received significant attention in the pharmaceutical food industries. Although there are many GABA-producing bacteria, high cost of strain cultivation limits its additive raw material application. In our study, Lactobacillus hilgardii GZ2, novel strain, was investigated. We attempted to replace nitrogen sources with silkworm pupae, waste resource silk reeling industry, GYP complex...

10.3390/fermentation9070691 article EN cc-by Fermentation 2023-07-24

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10.2139/ssrn.4786601 preprint EN 2024-01-01

The supplementary of Levilactobacillus brevis strains exerts anti-obesity effects by regulating gut microbiota, bile acid metabolism and gene expression pattern hepatic cells.

10.1039/d4fo03417a article EN Food & Function 2024-12-02

Influence of Mn 2+ , Mg and Ca on β-D-glucosidase activity produced by Xanthophyllomyces dendrorhous was measured. The presence could increase the change in cell morphology obviously improves growth astaxanthin biosynthesis. biomass, yield content dry reached to 3.65 g L -1 3.06 mg 0.84 at 72 h fermentation respectively, which were higher than those absence .

10.4028/www.scientific.net/amr.740.478 article EN Advanced materials research 2013-08-01
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