Abstract Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it closely related to SARS‐CoV and MERS‐CoV. The situation getting worse worse, therefore, there an urgent need designing suitable peptide vaccine component against SARS‐COV‐2. Here, we characterized spike glycoprotein obtain immunogenic epitopes. Next, chose 13 Major Histocompatibility Complex‐(MHC) I 3 MHC‐II epitopes, having antigenic properties. These...

Aim: COVID-19 is currently the biggest threat to mankind. Recently, ivermectin (a US FDA-approved antiparasitic drug) has been explored as an anti-SARS-CoV-2 agent. Herein, we have studied possible mechanism of action using in silico approaches. Materials & methods: Interaction against key proteins involved SARS-CoV-2 pathogenesis were investigated through molecular docking and dynamic simulation. Results: Ivermectin was found a blocker viral replicase, protease human TMPRSS2, which could be...

The effect of baker's yeast (Saccharomyces cerevisiae), in the diet Rohu (Labeo rohita) innate immune response were investigated.Indian major carps Labeo rohita fed with four different diets for eight weeks: a formulated as control and same supplemented 5%, 7.5% 10% an experimental diets.After every fifteen days interval growth parameters ( such ADG, SGR, FCR PER), Serological TSP,TSA, TSG A:G), Hematological TLC,TEC, Hct, MCV MCH ) Non-specific immunological PR, PI, Respiratory Burst...

SARS-CoV-2 is spreading globally at a rapid pace. To contain its spread and prevent further fatalities, the development of vaccine against an urgent prerequisite. Thus, in this article, by utilizing in-silico approach, candidate for has been proposed. Moreover, effectiveness safety measures our proposed epitopic have evaluated tools servers (AllerTOP AllergenFP servers). We observed that no allergenicity successfully combined with Toll-like receptor (TLR) protein to elicit inflammatory...

DNA barcoding appears to be a promising approach for taxonomic identification, characterization, and discovery of newer species, facilitating biodiversity studies. It helps researchers appreciate genetic evolutionary associations by collection molecular, morphological, distributional data. Fish barcoding, based on the sequencing uniform area Cytochrome C Oxidase type I (COI) gene, has received significant interest as an accurate tool species authentication, phylogenetic analysis. The aim...

Long-chain Polyunsaturated Fatty Acids (PUFAs) especially n-3 series such as Omega-3, Docosahexaenoic Acid (DHA), and Eicosapentaenoic perform necessary dietary supplements to consider the wellbeing of human health.Notably, these FAs evoked specific protein targeting biogenesis pathways in cytosol that prevents various disorders likewise; coronary heart disease, inflammatory liver problems, diabetes, brain development, eye cancer therapy well COVID-19.In regulation, PUFAs alter composition...

The freshwater fish diversity is significant in the food chain and a nutrient source. Our study sites are home to diversified fishes due their varied geography. For first time, length–weight relationships of ten Indigenous International Union for Conservation Nature-threatened species (were collected from different November 2019 December 2022 3-month intervals. There were various types nets with varying sizes mesh, including gill net (0.5 4 cm), scoop (0.3 × 0.3 0.5 cast (up 1 cm mesh up 3.0...

Antifreeze proteins (AFPs) are known to polypeptide components formed by certain plants, animals, fungi and bacteria which support survive in sub-zero temperature. Current study highlighted the seven different antifreeze of fish Ocean pout (Zoarces americanus), protein (amino acids sequence) were collected from National Centre for Biotechnology Information finely characterized using several silico tools. Such biocomputational techniques applied figure out physicochemical, functional...

To investigate the effect of inland groundwater salinity on growth performance, feed conversion efficiency, nutrient retention and intestinal enzyme activity in milkfish, two experiments were conducted. In first experiment (Expt I), a 100-day monoculture Chanos chanos [mean body weight (BW): 2.2 g] at different salinities (0, 10, 15, 20 25‰) was carried out ponds fertilized with cowdung (about 10 000 kg ha−1 year−1) poultry droppings 3000 year−1). The fish fed compounded supplementary diet...

Gram-negative bacteria is the main causative agents for columnaris disease outbreak to finfishes. The outer membrane proteins (OMPs) candidate of Flavobacterium columnare bacterial cell served a critical component cellular invasion targeted eukaryotic and survival inside macrophages. Therefore, OMPs considered as supreme element development promising vaccine against F. columnare. Implies advanced in silico approaches, predicted 3-D model were characterized by Swiss server validated through...

The present study attempts to assess the potential of artificial substrates enhance fish production in inland saline groundwater ponds through periphyton production. Grey mullet, Mugil cephalus, was cultured for 100 days with substrate (treatment ponds) and without (control ponds). To surface area, bamboo poles were used as substrate. population, pigment concentration hydrobiological characteristics pond water monitored. studies revealed little difference most quality parameters observed two...

The ichthyofauna in relation to water quality was studied on monthly basis from March, 2010 February, 2011 the Kangsabati Reservoir, West Bengal. study revealed that physicochemical parameters of Reservoir were congenial for 39 fish species commercial importance, belonging 7 orders, 15 families, and 26 genera. Cypriniformes dominant with 17 species, followed by Siluriformes Perciformes, each, Channiformes 3 Osteoglossiformes Synbranchiformes 2 Anguilliformes 1 species. Regarding their...

Leprosy is a significant universal health problem that remarkably still concern in developing countries due to infection frequency. New therapeutic molecules and next-generation vaccines are urgently needed accelerate the leprosy-free world. In this direction, present study was performed using two routes: proteome-mediated target identification mapping as well multi-epitopic peptide-based novel vaccine development state of art computational biology for TN strain M. leprae. The selected from...