A5022373908- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Diet, Metabolism, and Disease
- Cardiac electrophysiology and arrhythmias
- Electrolyte and hormonal disorders
- Genetic diversity and population structure
- Renal and Vascular Pathologies
- Lipoproteins and Cardiovascular Health
- Eicosanoids and Hypertension Pharmacology
- Infant Nutrition and Health
- Estrogen and related hormone effects
- Cardiac Arrhythmias and Treatments
- Hormonal Regulation and Hypertension
- ATP Synthase and ATPases Research
- Peripheral Artery Disease Management
- Adrenal Hormones and Disorders
- Mitochondrial Function and Pathology
- Human-Animal Interaction Studies
- Galectins and Cancer Biology
- Cardiovascular Syncope and Autonomic Disorders
- Chromatin Remodeling and Cancer
- Molecular Biology Techniques and Applications
- interferon and immune responses
National Institute of Environmental Health Sciences
2021-2024
Triangle
2021-2024
National Institutes of Health
2024
Covance (United Kingdom)
2016-2023
University of California, Davis
2016
Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits the synthesis of proprotein convertase subtilisin-kexin type 9 (PCSK9), target for lowering low-density lipoprotein (LDL) cholesterol.In this phase 1 trial, we randomly assigned healthy volunteers with an LDL cholesterol level at least 100 mg per deciliter in 3:1 ratio to receive subcutaneous injection inclisiran or placebo either single-ascending-dose (at dose 25, 100, 300, 500, 800 mg)...
To investigate the effects of semaglutide on fasting and postprandial glucose lipid responses, gastric emptying.
To assess the effects of oral semaglutide on postprandial glucose and lipid metabolism, gastric emptying, in subjects with type 2 diabetes (T2D).In this randomized, double-blind, single-centre, crossover trial, T2D received once-daily (escalated to 14 mg) followed by placebo, or vice versa, over two consecutive 12-week periods. Glucose emptying (paracetamol absorption) were assessed before after types standardized meals (standard and/or fat-rich) at end each treatment period. The primary...
Abstract The Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. consortium generated over 427 million sequences from cDNA and direct RNA datasets, encompassing human, mouse, manatee species, using different protocols sequencing platforms. These data were utilized by developers address challenges in transcript isoform detection quantification, as well de novo identification....
Abstract Purpose Galectin-3, a β-galactoside-binding lectin, plays key role in several cellular pathways involved chronic inflammation, heart disease and cancer. GB1211 is an orally bioavailable galectin-3 inhibitor, developed to be systemically active. We report safety pharmacokinetics (PK) of healthy participants. Methods This phase 1, double-blind, placebo-controlled, first-in-human study (NCT03809052) included single ascending-dose (with food-effect cohort) where participants across...
Aims High aldosterone is a key driver of hypertension and long‐term negative sequelae. We evaluated the safety efficacy dexfadrostat phosphate (DP13), novel synthase (CYP11B2) inhibitor, in healthy participants. Methods This randomized, double‐blind, placebo‐controlled study was conducted two parts. In part A, single‐ascending dose escalation, 16 participants received oral DP13 1–16 mg. Part B multiple‐ascending dose, sequential group which 32 4, 8 or mg once daily for days. Safety...
In-vitro data suggest that clearance of vilaprisan is mediated by cytochrome P450 3A4 (oxidation) and aldoketoreductases (reduction). To fully understand the elimination biotransformation pathways vilaprisan, a selective progesterone receptor modulator, to quantify impact inhibition on pharmacokinetics two clinical studies in healthy postmenopausal women were conducted. In study 1, pharmacokinetics, mass balance, metabolite patterns determined after single oral administration 5 mg...
Tamsulosin and mirabegron may be used concomitantly in patients with lower urinary tract symptoms. Since alpha1-adrenoceptor antagonists are associated cardiovascular side effects, potential pharmacokinetic interactions were evaluated.This was an open-label, randomized, 2-arm, 2-sequence study 48 healthy men (24/arm) aged 44 - 72 years. In arm 1, subjects received single-dose tamsulosin hydrochloride modified release capsules (0.4 mg) alone steady-state oral controlled absorption system...
Summary Maintenance of the mitochondrial inner membrane potential (ΔΨM) is critical for many aspects function, including protein import and ion homeostasis. While ΔΨM loss its consequences are well studied, little known about effects increased ΔΨM. In this study, we used cells deleted ATPIF1 , a natural inhibitor hydrolytic activity ATP synthase, as genetic model hyperpolarization. Our data show that chronic increase leads to nuclear DNA hypermethylation, regulating transcription...
Abstract This study assessed the safety, tolerability, and pharmacokinetics of single multiple oral doses DA‐8010, a muscarinic M 3 receptor antagonist, in healthy subjects. was randomized, double‐blind, placebo‐controlled, ascending (Part A: 1, 2.5, 5, 20, 40 mg QD fasted 10 fed) B: 10, 20 from Days 1 to 7 fasted), sequential‐group study. Safety data were analyzed descriptively, time maximum plasma concentration ( t max ) nonparametrically, pharmacokinetic parameters using power mixed...
Cranial neural crest cells (cNCC) are a multipotent embryonic cell population that give rise to diverse set of types. These particularly vulnerable external metabolic stressors, as exemplified by the association between maternal hyperglycemia and congenital malformations. We were interested in studying effect various concentrations glucose pyruvate on cNCC metabolism, migration, differentiation using an established murine model (O9-1). unexpectedly observed pattern gene expression suggestive...
Phenotypic and genotypic characteristics of the cat can be obtained from single nucleotide polymorphisms (SNPs) analyses fur. This study developed miniplexes using SNPs with high discriminating power for random-bred domestic cats, focusing on individual phenotypic identification. Seventy-eight were investigated a multiplex PCR followed by fluorescently labeled base extension (SBE) technique (SNaPshot(®) ). The SNP evaluated reliability, reproducibility, sensitivity, species specificity,...
The globulin fraction of the serum rabbits, immunized with living Hemophilus pertussis, was shown to protect mice against experimental infection this organism. intramuscular injection doses from 4 7 ml refined into infants, in early stage whooping cough, produced an immediate increase both mouse-protective and agglutinative titers infants' sera. In certain instances, there seemed be a beneficial effect upon clinical course disease, frequently definite decrease noted total number mononuclear...
Abstract The cancer hazard associated with exposure to cell phone radiofrequency radiation (RFR) was examined using lifetime in Sprague-Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were increased incidences of gliomas brain and schwannomas heart. In order understand translational relevance these rat tumors for human disease, we top 23 orthologous genes mutated a custom built next-generation sequencing gene panel based on Illumina’s TruSeq Custom Amplicon Technology. SD...
Omecamtiv mecarbil (OM) is a novel selective cardiac myosin activator under investigation for the treatment of heart failure. This study aimed to evaluate effect therapeutic concentrations OM on electrocardiogram (ECG) parameters and exclude clinically concerning rate-corrected QT (QTc) interval.In part A, 70 healthy subjects received 25 mg oral dose OM, pharmacokinetics were assessed. Only with maximum observed plasma concentration ≤ 350 ng/mL (n = 60) randomized into B, where they single...