Neurotoxicity is a significant clinical side effect of immunosuppressive treatment used in prophylaxis for rejection solid organ transplants. This study aimed to provide insights into the mechanisms underlying neurotoxicity patients receiving following renal transplantation. Clinical and neurophysiological assessments were undertaken 38 immunosuppression transplantation, 19 calcineurin inhibitor (CNI) therapy calcineurin-free (CNI-free) regimen. Groups matched age, gender, time since...

Background and objectives Neuromuscular complications are almost universal in CKD by the time that a patient commences dialysis. Recent studies have indicated chronic hyperkalemia may contribute to development of neuropathy CKD. This study was undertaken determine whether dietary restriction potassium intake be neuroprotective factor Design, setting, participants, & measurements A 24-month prospective, single-blind, randomized, controlled trial 47 consecutively recruited patients with...

Nephrotic syndrome is characterised by heavy proteinuria secondary to glomerular injury. It an uncommon but serious complication of allogeneic haematopoietic stem cell transplant (HSCT), rarely reported after autologous HSCT. Here, we report the case a man in his mid-20s who presented with significant peripheral oedema 2 months HSCT for Hodgkin lymphoma. Investigations demonstrated nephrotic range and hypoalbuminaemia. Renal biopsy minimal change disease. Initial treatment glucocorticoids...

In Brief Background and Objectives Current methods for rapid detection of delayed graft function (DGF) after kidney transplantation are unreliable. Urinary clusterin is a biomarker injury but its utility prediction dysfunction unknown. Methods single-center, prospective cohort study renal transplant recipients (N=81), urinary was measured serially between 4 hr 7 days transplantation. The DGF (hemodialysis within transplantation) compared with interleukin (IL)-18, neutrophil...

Background The early prediction of delayed graft function (DGF) would facilitate patient management after kidney transplantation. Methods In a single-centre retrospective analysis, we investigated kinetic estimated GFR under non-steady-state conditions, KeGFR, in DGF. KeGFRsCr was calculated at 4h, 8h and 12h 56 recipients deceased donor kidneys from initial serum creatinine (sCr) concentrations, production rate, volume distribution, the difference between consecutive sCr values. utility for...

Background mRNA for biomarkers of kidney injury extracted from urinary exosomes may reflect or predict levels the corresponding protein after transplantation and clinical outcomes. Methods Urinary were isolated patients following renal transplantation, healthy controls, with CKD. Expression exosomal neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), molecule-1 (KIM-1), cystatin C was compared concentrations proteins, 18S RNA serum creatinine. Results All biomarker...

Background Acute kidney injury (AKI) is common after severe paraquat poisoning and usually heralds a fatal outcome. The rapid large increases in serum creatinine (Cr) exceed that which can be explained by kinetics based on loss of glomerular filtration rate (GFR). Methods Findings This prospective multi-centre study compared the two surrogate markers GFR, cystatin C (CysC), following to understand assess renal functional poisoning. Sixty-six acute patients admitted medical units five...

Abstract Background Impaired physical function drives adverse outcomes in chronic kidney disease (CKD). Peripheral neuropathy is highly prevalent CKD, though its contribution to CKD patients unknown. This study examined the relationships between peripheral neuropathy, walking speed and quality of life (QoL) stages 3 4 CKD. Methods was a prospective observational investigating with an estimated glomerular filtration rate (eGFR) 15–60 mL/min/1.73 m2. A total 109 were consecutively recruited....

To determine: (i) the proportion of stable asymptomatic haemodialysis patients with elevated troponin; (ii) stability troponin values after dialysis and over a 2-week interval; (iii) whether high-sensitivity T (hsTnT) was associated higher prevalence cardiovascular risk factors or disease in these patients.We measured hsTnT fourth generation I before 103 in-centre without ischaemic symptoms. Patients were divided into quartiles to test for associations established disease.hsTnT above 99th...

Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. However, the performance pCysC for diagnosing acute kidney injury (AKI) after cisplatin-based chemotherapy is potentially affected by accompanying corticosteroid anti-emetic therapy and hydration.In prospective observational study pCysC, sCr, urinary molecule-1 (KIM-1), clusterin were measured over 2 weeks in 27 patients given first-cycle chemotherapy. The same variables Sprague-Dawley rats single...

Objectives Peripheral neuropathy is the most common neurological complication in end-stage kidney disease. While high flux hemodialysis (HFHD) and hemodiafiltration (HDF) have become preferred options for extracorporeal dialysis therapy, effects of these treatments on nerve excitability not yet been examined. Methods An observational proof-of-concept study was undertaken an incident population (n = 17) receiving either HFHD or HDF. Nerve techniques were utilised to assess ion channel...

Context. Colchicine is an anti-inflammatory alkaloid used for the treatment of acute gout, but has a narrow therapeutic index. overdoses are relatively rare, have high mortality requiring rapid treatment. Objective. To evaluate ability newly available ovine fragment antigen-binding (Fab) antibody to colchicine (ColchiFab™) protect rats against renal and other injury 24 h after ingestion. Materials methods. Rats were gavaged with (5 mg/kg), then 2 later injected intraperitoneally 5 ml sterile...

Abstract Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus IgA nephropathy. This cross-sectional observational study compared counts different forms glomerulonephritis. Consecutive individuals with glomerulonephritis attending a general renal or transplant clinic underwent retinal imaging non-mydriatic camera. Drusen were counted deidentified images by trained graders, matched hospital patients, correlated clinical features....

Drusen are retinal deposits comprising cell debris, immune material and complement that characteristic of macular degeneration but also found in glomerulonephritis. This was a pilot cross-sectional study to determine how often drusen occurred IgA glomerulonephritis their clinical significance. Study participants underwent non-mydriatic photography, deidentified images were examined for by two trained graders, who compared central counts, counts ≥ 10 size with those matched controls. The...

Toe brachial index (TBI), the ratio of toe pressure to systolic blood (SBP), helps predict peripheral arterial disease. In patients with kidney failure this may be performed during haemodialysis for convenience. Until recently there has been little evaluation impact in limb and systemic perfusion on these values. We aimed determine if values TBI would change after dialysis compared pre-dialysis assessments.

BACKGROUND: The effects of acute kidney injury (AKI) extend beyond the illness phase. Patients who survive AKI are at increased risk hospital readmission, chronic disease including and cardiovascular disease, frailty death. may be overlooked among more obvious or complex healthcare concerns. While developing a cogent, systemic response to care after is neglected public health priority, attention several common challenges improve patient outcomes. OBJECTIVE: aim this article highlight in...