A5023051766- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Analytical Methods in Pharmaceuticals
- Advanced Neuroimaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Neurological disorders and treatments
- Computational Drug Discovery Methods
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
University of Minnesota
2020-2024
University of Minnesota System
2020
Abstract Cardiotoxicity continues to be a major health issue worldwide due the imperative need access new or repurposed drugs that are safe and effective. Accessibility affordable is also key ensure all patients who require them. In this work we propose workflow for an in-silico clinical trial at 3D biventricular human population level, assess cardiac pro-arrhythmic risk after administration of single combination potentially cardiotoxic drugs. The proposed aims reproducing gender-specific...
Abstract Background The DiamondTemp ablation (DTA) system is a novel temperature-controlled irrigated radiofrequency (RF) that accurately measures tip-tissue temperatures for real-time power modulation. Lesion morphologies from longer RF durations with the DTA have not been previously described. We sought to evaluate lesion characteristics of when varying application durations. Methods A bench model using porcine myocardium was used deliver discrete lesions in simulated clinical environment....
Abstract Electroanatomical mapping provides key insights into cardiac function and arrhythmia location. Epicardial allows for the recording of electrograms from body surface that can be combined with an anatomical geometry to create a real-time functional voltage map electrical activity. Isolated heart models, like those studied on Visible Heart® apparatus, provide valuable platform medical device design but are often limited modified 3-lead electrocardiograms do not anatomically specific...
Abstract Epicardial ablations are being utilized as alternative techniques to the current endocardial procedures. An epicardial approach offers some advantages, especially when treating ventricular arrhythmias, e.g., those that have or transmural sites of origin. However potential collateral damage from these applied myocardial surface has not been fully explored. In order better visualize and understand such effects on acute coronary functioning, we employed intracoronary optical coherence...
Cardiac myofiber structure and organizations play critical roles in the electrical mechanical properties of heart. Diffusion tensor magnetic resonance imaging (DTMRI) has been a useful modality to visualize myocardial fiber orientation with emerging clinical application. DTMRI takes advantage limited diffusion water along cardiac fiber’s longitudinal axis provides dominant direction . Until recently, usage was relatively white matter within brain. While there are limitations for use vivo ,...
Abstract Electroanatomical mapping systems are being utilized clinically for locating arrhythmias within a given patient’s heart. Today, employed endocardial invasive and require extensive set-up time. Epicardial systems, like CardioInsight™ from Medtronic, non-invasive but co-registration of electrodes to the heart, e.g. via required Computed Tomography (CT) scan. This system has been used both in several laboratories situ. The difficulties with vitro uses that ex vivo perfused hearts lack...
Abstract Human ventricular cardiac anatomy is extremely complex. Access to the chambers are often necessary for both mapping and treating arrhythmias. To date, electrophysiologists who perform these catheter ablations typically rely on fluoroscopy patient specific electroanatomical maps they generate so begin navigate through complex functional anatomies. However, limited resolutions do not provide required insights relative actual anatomical barriers. Hence, such discordances can lead...