Leadless pacemakers have been developed to avoid some of the complications that are associated transvenous pacemakers. Pericardial effusion is a rare complication leadless pacemaker implantation, which may result from perforation delivery catheter. In this study, we describe preclinical performance an updated Micra catheter.To assess catheter, three analyses were performed. First, Finite Element Analysis (FEA) computational modeling was performed estimate target tissue stress during catheter...

Today, there is no manufacturer-supplied retrieval tool for the Micra™ pacemaker (Medtronic, Minneapolis, MN, USA); therefore, off-the-shelf catheters have been employed retrievals. The proximal feature of can be snared and device then retracted from myocardium, pulling through tricuspid valve. This study characterizes potential risks nitinol tine engagement with sub-valvular apparatus.Fresh human hearts nonviable transplant (n = 10) were obtained our regional organ procurement agency...

Key Teaching Points•On occasion leadless pacemakers need to be retrieved despite outcomes showing reduced or minimal chronic complications. Complications might include elevated pacing thresholds, for alternate therapy, pacemaker syndrome, prosthetic valve endocarditis.•This case report shows the successful retrieval of a chronically implanted in reanimated swine using direct visualization.•Images presented this have notable educational value clinicians and design engineers. •On

Epicardial electrophysiological procedures rely on dependable interfacing with the myocardial tissue. For example, epicardial pacing systems must generate sustainable chronic capture, while ablations effectively deliver energy to target hyper‐excitable myocytes. The human heart has a significant adipose layer which may impede procedures. objective of this study was quantitatively assess relative location heart, define locations where therapies might be performed successfully. We studied...

Data relative to anatomical measurements, spatial relationships, and device–tissue interaction are invaluable medical device designers. However, obtaining these datasets from a wide range of specimens can be difficult time consuming, forcing designers make decisions on the requisite shapes sizes restricted number specimens. The Visible Heart® Laboratories have unique library over 500 perfusion-fixed human cardiac organ donors whose hearts (and or lungs) were not deemed viable for...

Key Teaching Points•His-bundle pacing (HBP) provides an alternative to right ventricular pacing, but it requires the precise placement of a lead onto His bundle.•Using direct visualization within reanimated human hearts, we provide understanding anatomy central HBP implantations.•In both patient cases, selective capture was achievable at low output, whereas fusion seen high outputs, suggesting His–Purkinje tissues. •His-bundle

Cardiac transplant outcomes can be compromised by the effects of global ischemia and associated reperfusion injury. In attempts to alleviate these phenomena, various pharmaceutical agents administered. Previous reports have shown that adenosine triphosphate (ATP) may act as either a postconditioning (PoC) or supplementary (Sup) therapy with cardiosupportive benefits. To further evaluate ATP's relative effectiveness, we used an isolated swine heart four-chamber working model monitor both...

Estimated rates of acute pacemaker lead perforations range between 0.5% and 2%, thus establishing significant clinical device design considerations, i.e., given that over 250,000 patients are annually implanted with permanent pacing systems [1,2]. The most common locations for such within the thinly walled right atrium, these in turn may result cardiac effusion which can be a issue. Yet, to date, little research has been reported relative biomechanical properties atrial tissues. Therefore,...

Between 1993 and 2009, 2.9 million patients received permanent pacemakers in the United States, with over 600,000 new implants every year, establishing a great clinical need for pacing therapy. This work is aimed at generating an isolated atrial perfusion easy access, higher throughput testing of novel or ablation technologies. In this pilot study, swine hearts (n = 4) portion human donor 1) heart (non-viable transplant) were acquired. The specimens transsectioned atrioventricular valve...

The Dahl SS rat is a well-established model of human salt-sensitive hypertension and renal disease. Recently, sodium-independent effects diet, particularly during gestation, were shown to be important in the development this disease phenotype. SS/JrHsdMcwiCrl (SS/Crl) rats fed grain-based diet (Teklad 5L2F) less susceptible salt-induced blood pressure elevation damage compared SS/JrHsdMcwi (SS/Mcw) casein-based (AIN-76A). With known role immune system hypertension, present study...

Developing a successful cardiac device requires detailed knowledge of mechanical properties. For example, tissue failure characteristics and compliance feed into design criteria for many pacemaker leads (Zhao et al., 2011). In the right atrium, tensile forces are exerted on atrial appendage in multiple clinical procedures. traditional lead implant, manipulations with stylet aid clinician assessing fixation, seldom used “tug” test providing additional input. Atrial dislodgement remains one...