A5025097271- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
University of Copenhagen
2014-2019
Danish National Research Foundation
2015
Type 2 diabetes is associated with abnormal electrical conduction and sudden cardiac death, but the pathogenic mechanism remains unknown. This study describes electrophysiological alterations in a diet-induced pre-diabetic rat model examines underlying mechanism. Sprague–Dawley rats were fed either high-fat diet fructose water or normal chow for 6 weeks. The properties of whole heart was analyzed by vivo surface ECG recordings, as wells ex Langendorff perfused hearts during baseline,...
Diabetic patients suffer from both cardiac lipid accumulation and an increased risk of arrhythmias sudden death. This correlation suggests a link between diabetes induced steatosis electrical abnormalities, however, the underlying mechanism remains unknown. We previously showed that conduction velocity slows in Zucker diabetic fatty rats fructose-fat fed rats, models exhibit prominent steatosis. The aim this study was to investigate whether acute reduces per se. Cardiac acutely by perfusing...