A5045619740- RNA Research and Splicing
- MicroRNA in disease regulation
- interferon and immune responses
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- HVDC Systems and Fault Protection
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- Receptor Mechanisms and Signaling
Indian Institute of Science Bangalore
2021-2022
Institute for Stem Cell Biology and Regenerative Medicine
2018-2021
SASTRA University
2018-2021
Apolipoprotein E (APOE), one of the primary lipoproteins in brain has three isoforms humans, APOE2, APOE3, and APOE4. APOE4 is most well-established risk factor increasing predisposition for Alzheimer's disease (AD). The presence allele alone shown to cause synaptic defects neurons recent studies have identified multiple pathways directly influenced by However, mechanisms underlying APOE4-induced dysfunction remain elusive. Here, we report that acute exposure cortical or synaptoneurosomes...
SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1+/-) has been shown to cause Intellectual Disability (ID) children. Recent studies have provided evidence for altered neuronal protein synthesis mouse model of Syngap1+/-. However, the molecular mechanism behind same is unclear. Here, we report reduced expression known translation regulator, FMRP, specific period Syngap1+/- mice. Our...
Precise development of the dendritic architecture is a critical determinant mature neuronal circuitry. MicroRNA (miRNA)-mediated regulation protein synthesis plays crucial role in morphogenesis, but miRNA-induced silencing complex (miRISC) components this process less studied. Here, we show an important key miRISC protein, GW182 paralog TNRC6A, growth. We identified distinct brain region-specific spatiotemporal expression pattern during rat postnatal development. found that window peak...
Abstract Epitranscriptome modifications are crucial in translation regulation and essential for maintaining cellular homeostasis. N6 methyladenosine (m 6 A) is one of the most abundant well-conserved epitranscriptome modifications, which known to play a pivotal role diverse aspects neuronal functions. However, m A with respect activity-mediated synaptic plasticity has not been studied. Here, we investigated modification response NMDAR stimulation. We have consistently observed that 5 min...
Abstract SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during critical developmental window. Heterozygous mutation in SYNGAP1 ( +/- ) has been shown to cause Intellectual Disability (ID) children. Recent studies have provided evidence for altered neuronal protein synthesis mouse model of Syngap1 . However, the molecular mechanisms behind same is unclear. Here, we report reduced expression known translation regulator, FMRP, specific period mice. Our results...
Abstract Precise development of the dendritic architecture is a critical determinant mature neuronal circuitry. MicroRNA-mediated regulation protein synthesis plays crucial role in morphogenesis but miRISC components this process less studied. Here, we show an important key GW182 growth. We have identified distinct brain region specific Spatio-temporal expression pattern during rat postnatal development. found that window peak coincides with period extensive growth, both hippocampus and...
Abstract Epitranscriptome modifications are crucial in translation regulation and essential for maintaining cellular homeostasis. N6 methyladenosine (m 6 A) is one of the most abundant well-conserved epitranscriptome modifications, which known to play a pivotal role diverse aspects neuronal functions. However, m A with respect activity-mediated synaptic plasticity has not been studied. Here, we investigated modification response NMDAR stimulation. We have consistently observed that upon...