A5082109212- Immunotherapy and Immune Responses
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Global Public Health Policies and Epidemiology
- Cardiac Valve Diseases and Treatments
- Nutritional Studies and Diet
- CAR-T cell therapy research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
- Obesity, Physical Activity, Diet
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Chronic Kidney Disease and Diabetes
- Ocular Infections and Treatments
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmacological Receptor Mechanisms and Effects
- Respiratory viral infections research
Shaheed Rajaei Cardiovascular Medical and Research Center
2023-2025
Iran University of Medical Sciences
2023-2025
Shahid Beheshti University of Medical Sciences
2021-2024
Universal Scientific Education and Research Network
2023-2024
Tabriz University of Medical Sciences
2023-2024
University of Pittsburgh Medical Center
2024
Tehran University of Medical Sciences
2022
Shariati Hospital
2022
University of Pittsburgh
2021
University of California, Los Angeles
2009
Influenza-related complications continue to be a major cause of mortality worldwide. Due unclear mechanisms, substantial number influenza-related deaths result from bacterial superinfections, particularly secondary pneumococcal pneumonia. Here, we report what believe novel mechanism by which influenza-induced type I IFNs sensitize hosts infections. Influenza-infected mice deficient for IFN-alpha/beta receptor signaling (Ifnar-/- mice) had improved survival and clearance Streptococcus...
Low back pain (LBP) is one of the most debilitating and prevalent disorders. The prevalence LBP ranges from 30% to 80%, depending on population, increases with age. Causes are typically classified as spinal non-spinal. main goal this study was investigate non-spinal causes LBP, since neglecting these factors leads in financial, psychological, physical burden individuals well society.
Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular fibrillation (AF) patients. The population was 1428 patients with AF, 875 of whom enrolled. Based on LAAV, were divided into three groups 262 <25 cm/s, 360 25 to 55 253 >55 cm/s assess compare terms indices, including platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte systemic immune inflammation index,...
This study aimed to quantify the incidence of Contrast-induced nephropathy (CIN) in patients undergoing primary percutaneous coronary intervention (PPCI) due acute ST-elevation myocardial infarction (STEMI).
To investigate the global, regional, and national burden of diseases attributable to excess body weight (EBW) from 1990 2019, stratified by age, sex, underlying cause, sociodemographic index (SDI). Using Comparative Risk Assessment approach Global Burden Disease (GBD) study EBW was reported for period 2019. For adults, defined as a mass (BMI) exceeding 25 kg/m2, while children aged 1 19 years, determined according standards set International Obesity Taskforce. The in terms numbers,...
Abstract Background Primary carnitine deficiency (PCD) denotes low levels with an autosomal recessive pattern of inheritance. Cardiomyopathy is the most common cardiac symptom in patients PCD, and early diagnosis can prevent complications. Next-generation sequencing identify genetic variants attributable to PCD efficiently. Objective We aimed detect cause manifestations hypertrophic cardiomyopathy metabolic abnormalities Iranian family. Methods herein describe 8-year-old boy symptoms...
Abstract: Gene silencing through RNA interference (RNAi) technology has provided forceful therapeutic modalities to specific knockdown of the genes' expression related diseases. Small interfering RNAs (siRNAs) can start a process that specifically degrades and silences cognate mRNAs. These processes could effectively adjust many biological processes, including immune responses. Dendritic cells (DCs) are specialist antigen-presenting with potent functions in regulating innate adaptive...
Kidney cancer, a type of urogenital imposes high burden on patients. Despite this, no recent research has evaluated the this cancer in Middle East and North Africa (MENA) region. This study explored kidney from 1990 to 2019 according age, sex socio-demographic index (SDI). The Global Burden Disease (GBD) data was utilized estimate incidence, death, disability-adjusted life-years (DALYs) caused by cancer. These estimates were reported as counts age-standardised rates with 95% uncertainty...
Multiple sclerosis (MS) is a progressively debilitating disorder that has seen notable rise in prevalence recent years. This study examines the burden of MS from 1990 to 2019, providing detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries territories.
Gastric cancer, ranked as the fifth most common cancer worldwide, presents multiple treatment challenges. These obstacles often arise due to stem cells, which are associated with recurrence, metastasis, and drug resistance. While dendritic cell (DC)-based immunotherapy has shown promise a therapeutic strategy, its efficacy can be limited by tumor microenvironment certain inhibitory immune checkpoint molecules, such B7H7. SiRNA-medicated knockdown of B7H7 in lysate-pulsed DCs increase...
Paravalvular leaks (PVL) following mitral valve replacement occur in 7% to 17% of cases, with 1% 5% being clinically significant. Although surgical repair is often recommended, transcatheter PVL closures have shown positive outcomes fewer complications. This case report discusses a patient severe paravalvular leak after aortic and treated via transapical approach, evaluating potential