Abstract This study describes the association of curcumin with light emitting diode (LED) for inactivation Candida albicans . Suspensions were treated nine concentrations and exposed to LED at different fluences. The protocol that showed best outcomes was selected evaluate effect preirradiation time (PIT) on photodynamic therapy (PDT) effectiveness, uptake by C. cells possible involvement singlet oxygen in action. Curcumin‐mediated PDT also assessed against biofilms. In addition...

Although photodynamic therapy (PDT) has shown great promise for the inactivation of Candida species, its effectiveness against azole-resistant pathogens remains poorly documented. This in vitro study describes association Photogem® (Photogem, Moscow, Russia) with LED (light emitting diode) light photoinactivation fluconazole-resistant (FR) and American Type Culture Collection (ATCC) strains albicans glabrata. Suspensions each strain were treated five concentrations exposed to four fluences...

Abstract Background and Objective The resistance of Candida species to antifungals represents a major challenge for therapeutic prophylactic strategies. This study evaluated photodynamic therapy (PDT) mediated by Curcumin (CUR) against clinical isolates C. albicans, tropicalis, glabrata , both in planktonic biofilm forms. Study Design/Materials Methods Suspensions were treated with three CUR concentrations exposed four LED fluences. protocol that showed the best outcomes inactivation phase...

In vitro investigations of curcumin-mediated photodynamic therapy (PDT) are encouraging, but there is a lack reliable in vivo evidence its efficacy. This study describes the photoinactivation Candida albicans murine model oral candidiasis, using curcumin as photosensitizer. Forty immunosuppressed mice were orally inoculated with C. and after five days, they received topical (20, 40 80 μM) illumination LED light. The use or light alone also investigated. Positive control animals did not...

The aim of this study was to evaluate the effects pre-irradiation time (PIT) on curcumin (Cur)-mediated photodynamic therapy (PDT) against planktonic and biofilm cultures reference strains Candida albicans, glabrata dubliniensis. Suspensions biofilms species were maintained in contact with different concentrations Cur for intervals 1, 5, 10 20 min before irradiation LED (light emitting diode) activation. Additional samples treated only Cur, without illumination, or light, Cur. Control...

Curcumin (CUR) has been used as photosensitizer in antimicrobial Photodynamic Therapy (aPDT). However its poor water solubility, instability, and scarce bioavalibility hinder vivo application. The aim of this study was to synthesize curcumin polymeric nanoparticles (NP) evaluate their photodynamic effect cytoxicity. CUR anionic cationic NP synthesized using polylactic acid dextran sulfate by the nanoprecipitation method. For NP, cetyltrimethylammonium bromide added. CUR-NP were characterized...

This investigation evaluated the effectiveness of an infection control protocol for cleansing and disinfecting removable dental prostheses. Sixty-four dentures were rubbed with sterile cotton swab immediately after they had been taken from patients' mouths. Samples individually placed in culture medium incubated at 37 +/- 2 degrees C. The scrubbed 1 min 4% chlorhexidine, rinsed water 10 one following immersion solutions: chlorhexidine gluconate, 1% sodium hypochlorite, Biocide (iodophors)...

The adhesion of Candida albicans to surfaces is the prerequisite for occurrence denture stomatitis.Hence, this study investigated if surface modifications with plasma treatments could reduce adherence C. a base resin.Specimens (n=180) roughened and smooth were made divided into five groups: control-specimens left untreated; experimental groups-specimens submitted obtain different hydrophobicity (Ar/50W; ArO2/70W; AAt/130W) or incorporation fluorine (Ar/SF(6)70W). Contact angle measurements...

Antimicrobial photodynamic therapy (aPDT) has been proposed as an alternative method for oral candidiasis (OC), while nanocarriers have used to improve the water solubility of curcumin (CUR). The aim this study is encapsulate CUR in polymeric nanoparticles (NPs) and evaluate its effects on a murine model OC. Anionic cationic CUR-NP synthesized using poly-lactic acid dextran sulfate then characterized. Female mice are immunosuppressed inoculated with Candida albicans (Ca) induce aPDT...

This study evaluated the effectiveness of antimicrobial photodynamic therapy (aPDT) in treatment oral candidiasis a murine model using Photodithazine® (PDZ). was developed to allow monitoring infection and establishment aPDT treatment. Six-week-old female mice were immunosuppressed inoculated with C. albicans induce candidiasis. PDZ-mediated nystatin carried out for 5 consecutive days one application per day. The macroscopic evaluation lesions performed. After each treatment, tongue swabbed...

The effectiveness of microwave disinfection maxillary complete dentures on the treatment Candida-related denture stomatitis was evaluated. Patients (n = 60) were randomly assigned to one four groups 15 subjects each;patients performed routine care; Mw group: patients had their upper microwaved (650 W per 6 min) three times week for 30 days; group MwMz: received in conjunction with topical application miconazole day Mz: antifungal therapy MwMz. Cytological smears and mycological cultures...

Purpose : Potential effects on hardness and roughness of a necessary effective disinfecting regimen (1% sodium hypocholorite 4% chlorhexidine) were investigated for two hard chairside reline resins versus heat‐polymerizing denture base acrylic resin. Materials Methods Two standard reliners (Kooliner Duraliner II), one heat‐treated reliner (Duraliner II +10 minutes in water at 55°C), material (Lucitone 550) exposed to solutions hypochlorite; chlorhexidine gluconate), tested surface properties...

Abstract Purpose: This study evaluated the effectiveness of different exposure times microwave irradiation on disinfection a hard chairside reline resin. Materials and Methods: Sterile specimens were individually inoculated with one tested microorganisms ( Pseudomonas aeruginosa , Staphylococcus aureus Candida albicans Bacillus subtilis ) incubated for 24 hours at 37°C. For each microorganism, 10 not microwaved (control), 50 microwaved. Control immersed in sterile saline, replicate aliquots...

This study evaluated the clinical effectiveness of two exposure times microwave irradiation on disinfection complete dentures.Biofilm samples were collected from dentures 30 patients, who randomly divided into experimental groups 15 subjects each: Group 1-patients had their maxillary denture microwaved for 3 min (650W); 2-patients 2 (650W). Denture biofilm taken with swabs, before (left side surfaces) and after (right irradiation. All microbial material was plated selective media Candida...