A5035675058- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Neurological disorders and treatments
- Particle Detector Development and Performance
- Particle physics theoretical and experimental studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced SAR Imaging Techniques
- Neuroscience and Neural Engineering
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Quantum Chromodynamics and Particle Interactions
- Nuclear Physics and Applications
- Visual perception and processing mechanisms
- High-Energy Particle Collisions Research
- Mental Health Research Topics
- Geophysics and Gravity Measurements
- Complex Network Analysis Techniques
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Microwave Imaging and Scattering Analysis
- Game Theory and Applications
- Radar Systems and Signal Processing
- Radiation Therapy and Dosimetry
- Opinion Dynamics and Social Influence
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2011-2023
Zhejiang Lab
2023
Brookhaven National Laboratory
2001-2021
North Carolina State University
2021
University of North Carolina at Chapel Hill
2021
Hefei University of Technology
2021
Thomas Jefferson National Accelerator Facility
2019
Luoyang Institute of Science and Technology
2018
Beijing University of Civil Engineering and Architecture
2018
Abstract Subthalamic deep brain stimulation (DBS) is superior to medical therapy for the motor symptoms of advanced Parkinson's disease (PD), and additional evidence suggests that it improves refractory essential tremor, primary generalized dystonia, obsessive‐compulsive disorder. Despite this, its therapeutic mechanism unknown. We hypothesized subthalamic activates cerebral cortex at short latencies after stimulus onset during clinically effective PD. In 5 subjects (six hemispheres), EEG...
Multiple studies have shown bilateral improvement in motor symptoms Parkinson disease (PD) following unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) and internal segment globus pallidus, yet mechanism(s) underlying this phenomenon are poorly understood. We hypothesized that STN neuronal activity is altered by contralateral DBS. This hypothesis was tested intraoperatively humans with advanced PD using microelectrode recordings during demonstrate alterations discharge...
ABSTRACT Deep brain stimulation (DBS) in Parkinson's disease (PD) is frequency‐dependent. Past studies of the effect DBS frequency, however, involved scrutiny too few frequencies to eliminate risk undersampling. Also, these presented averaged measures across subjects; high intersubject variability makes problematic. In this study, 6 subjects with PD were tested a drug‐minimal state. Following 10 minutes at new all available tested. Hand‐opening and hand‐closing amplitude frequency measured 3...
Abstract Deep brain stimulation (DBS) relieves disabling symptoms of neurologic and psychiatric diseases when medical treatments fail, yet its therapeutic mechanism is unknown. We hypothesized that ventral intermediate (VIM) nucleus for essential tremor activates the cortex at short latencies, this potential related to suppression in contralateral arm. measured cortical activity with electroencephalography 5 subjects (seven hemispheres) across a range stimulator settings, reversal anode...
For a spaceborne high-resolution and wide-swath synthetic aperture radar (HRWS-SAR) system, it usually uses the digital beamforming technology. However, in practice, because of influences temperature, antenna pattern, receiving antenna, other error factors, there may exist range synchronization time errors, amplitude phase errors among different spatial channels. These nonideal factors will significantly degrade multichannel data reconstruction performance, resulting smeared SAR image. To...
Deep brain stimulation is an effective treatment for movement disorders, but it relatively complex, invasive, and costly. Little known about whether mode alters pulse generator (battery) longevity in routine clinical care.To compare battery during monopolar versus bipolar patients who underwent deep disorders.We evaluated 2,902 programming adjustments calculated the average stimulator settings 393 batteries 200 unique with Parkinson's disease essential tremor. We classified generators into...
We report a measurement of cumulants and correlation functions event-by-event proton multiplicity distributions from fixed-target Au+Au collisions at $\sqrt{s_{\rm NN}}$ = 3 GeV measured by the STAR experiment. Protons are identified within rapidity ($y$) transverse momentum ($p_{\rm T}$) region $-0.9 < y<0$ $0.4 p_{\rm T} <2.0 $ GeV/$c$ in center-of-mass frame. A systematic analysis up to sixth-order as well corresponding ratios function collision centrality, $p_{\rm T}$, $y$ presented. The...
The neural dynamics underlying the coordination of spatially-directed limb and eye movements in humans is not well understood. Part difficulty has been a lack signal processing tools suitable for analysis nonstationary electroencephalographic (EEG) signals. Here, we use multivariate empirical mode decomposition (MEMD), data-driven approach that does employ predefined basis functions. High-density EEG, arm were synchronously recorded 10 subjects performing time-constrained reaching and/or...
There has been a long-running debate over whether humans match or maximize when faced with differentially rewarding options under conditions of uncertainty. While maximizing, that is, consistently choosing the most option, is theoretically optimal, have often observed to match, allocating choices stochastically in proportion underlying reward rates. Previous models assumed matching behavior arise from biological limitations heuristic decision strategies; this, however, would stand curious...
Abstract Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms action remain unclear. With respect to Parkinson's disease, the existence multiple targets suggests that putamen also may be and raises questions as action. Are there many are or some single small set common all targets? During course routine surgery globus pallidus interna in patients with deep lead was placed en route interna. Recordings hand opening closing during...
Dysfunctions of approach and avoidance motivation play an important role in depression, which turn may affect cognitive control, i.e., the ability to regulate thoughts action achieve internal goals. We use a novel experimental paradigm, i.e. computer simulated driving-task, study impact depression on control by measuring actions continuous time. In this task, 39 subjects with minimal severe symptoms were instructed joystick move virtual car as quickly possible target point without crossing...
Efficient methods for Local Field Potential (LFP) signal analysis amenable to interpretation are becoming increasingly relevant. LFP signals believed, in part, reflect neural action potential activity, and frequency modulations linked spiking events. Furthermore, accessible human brain regions previously unreachable due a proliferation of deep stimulation implantation procedures. Traditional involves computing power spectra densities (PSDs) these signals, which captures at various...
Abstract Unilateral and bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease (PD) result weight gain the initial postoperative months, but little is known about changes following unilateral staged STN DBS over longer time intervals. A case–control comparison evaluated 2 years 43 consecutive patients, among whom 25 elected to undergo DBS, 21 age‐matched severity matched PD controls without DBS. Regression analyses incorporating age, gender, baseline case or...
The polarization measurement through elastic (p⃗,C) reaction plays a crucial role in the polarized proton beam operation of Relativistic Heavy Ion collider at Brookhaven National Laboratory. As well as measuring polarization, unknown analyzing power AN is determined combination with absolute meausement by H‐jet polarimeter. systematic uncertainty Run05 measurements are discussed introducing experimental apparatus polarimeter system.
An important but poorly understood aspect of sensory processing is the role active sensing, use self-motion such as eye or head movements to focus sensing resources on most rewarding informative aspects environment. Here, we present behavioral data from a visual search experiment, well Bayesian model within-trial dynamics and movements. Within this Bayes-optimal inference control framework, which call C-DAC (Context-Dependent Active Controller), various types costs, temporal delay, response...
Several theories posit increased Subthalamic Nucleus (STN) activity is causal to Parkinsonism, yet in our previous study we showed that from 113 STN neurons two epilepsy patients and 103 nine Parkinson's disease (PD) demonstrated no significant differences frequencies or the coefficients of variation mean discharge per 1-s epochs. We continued analysis using point process modeling capture higher order temporal dynamics; particular, bursting, beta-band oscillations, excitatory inhibitory...
Differentiating the ability from motivation to act is of central importance psychiatric disorders in general and depression particular. However, it has been difficult develop quantitative approaches relate poor motor performance goal-directed tasks. Here, we use an inverse optimal control approach provide a computational framework that can be used infer factorize deficits into three components: sensorimotor speed, goal setting motivation. Using novel computer-simulated driving experiment,...
Precise and absolute beam polarization measurements are critical for the RHIC spin physics program. Because all experimental spin‐dependent results normalized by polarization, normalization uncertainty contributes directly to final uncertainties. We aimed perform measurement an accuracy of ΔPbeam/Pbeam<5%. The polarimeter consists Polarized Atomic Hydrogen Gas Jet Target left‐right pairs silicon strip detectors was installed in RHIC‐ring 2004. This system features proton‐proton elastic...