A5023445706- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Microbial Community Ecology and Physiology
- Receptor Mechanisms and Signaling
- Bacteriophages and microbial interactions
- Heart Failure Treatment and Management
- Legume Nitrogen Fixing Symbiosis
- Renin-Angiotensin System Studies
- Bioinformatics and Genomic Networks
- Phosphodiesterase function and regulation
- Genetics, Aging, and Longevity in Model Organisms
- Chromosomal and Genetic Variations
SickKids Foundation
2022-2024
Hospital for Sick Children
2023
McMaster University
2020-2022
Phosphodiesterase 3A (
High blood pressure (BP) is the major risk factor for cardiovascular disease. Genome-wide association studies have identified genetic variants BP, but functional insights into causality and related molecular mechanisms lag behind. We functionally characterize 4,608 in linkage with 135 BP loci vascular smooth muscle cells cardiomyocytes by massively parallel reporter assays. densities of regulatory at (i.e., ULK4, MAP4, CFDP1, PDE5A) indicate that multiple drive association. Regulatory are...
Abstract Gene expression in bacteria is a remarkably controlled and intricate process impacted by many factors. One such factor the genomic position of gene within bacterial genome. Genes located near origin replication generally have higher level, increased dosage, are often more conserved than genes farther from replication. The majority studies involved with these findings only noted this phenomenon single or cluster that was re-located to pre-determined positions In work, we look at...
Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, their extent fundamental principles across cell types remain controversial. We develop a supervised unsupervised learning algorithm, termed Signature, call Hi-C datasets advance our understanding of topology. Signature reveals 40,282 properties 62 53 diploid human types....
Genomic reorganization, such as rearrangements and inversions, influences how genetic information is organized within the bacterial genomes. Inversions, in particular, facilitate genome evolution through gene gain loss, can alter expression. Previous studies have investigated impact inversions on expression induced targeting specific genes or examine between distantly related species. This fails to encompass a genome-wide perspective of naturally occurring their post-adaptation Here, we used...
Increasing evidence supports the notion that different regions of a genome have unique rates molecular change. This variation is particularly evident in bacterial genomes where previous studies reported gene expression and essentiality tend to decrease, whereas substitution usually increase with increasing distance from origin replication. Genomic reorganization such as rearrangements occur frequently bacteria allow for introduction restructuring genetic content, creating gradients traits...