A5046012009- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chromatin Remodeling and Cancer
- Multiple Myeloma Research and Treatments
- Cancer, Lipids, and Metabolism
- Tumors and Oncological Cases
- Cardiac tumors and thrombi
- Virus-based gene therapy research
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
University of Toronto
2023-2024
SickKids Foundation
2022-2024
Hospital for Sick Children
2023-2024
The causes of pediatric cancers' distinctiveness compared to adult-onset tumors the same type are not completely clear and fully explained by their genomes. In this study, we used an optimized multilevel RNA clustering approach derive molecular definitions for most childhood cancers. Applying method 13,313 transcriptomes, constructed a cancer atlas explore age-associated changes. Tumor entities were sometimes unexpectedly grouped due common lineages, drivers or stemness profiles. Some...
Abstract NUT carcinoma (NC) is an aggressive squamous defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The lack of adequate animal model precludes identifying and leveraging cell-extrinsic factors therapeutically in NC. Here, we created a genetically engineered mouse (GEMM) that forms Brd4::NUTM1 gene upon tamoxifen induction Sox2-driven Cre. displayed complete disease penetrance, with tumors arising from epithelium...
Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, their extent fundamental principles across cell types remain controversial. We develop a supervised unsupervised learning algorithm, termed Signature, call Hi-C datasets advance our understanding of topology. Signature reveals 40,282 properties 62 53 diploid human types....
Abstract Objectives: Mesenchymal neoplasms, or sarcomas, are a diverse and diagnostically challenging group including >150 histotypes, biased to pediatric patients, comprising 20% of solid tumor diagnoses compared 1% in adults. A universal molecular taxonomy classification system for sarcoma would be an invaluable tool patient diagnosis subtype discovery. We previously demonstrated transcriptional pan-cancer classifier; however, we neither captured the full diversity mesenchymal...
<p>Supplementary Fig. S3. mNC-derived cell lines share transcriptional profiles with tumor tissues that are characterized by MYC pathway upregulation.</p>
<p>Supplementary Fig. S1. Creation of an inducible, highly penetrant genetically engineered mouse model NUT carcinoma.</p>
<p>Supplementary Fig. S5. H3K27me3 and H3K27ac domains are mutually exclusive.</p>
<div>Abstract<p>NUT carcinoma (NC) is an aggressive squamous defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The lack of adequate animal model precludes identifying and leveraging cell-extrinsic factors therapeutically in NC. Here, we created a genetically engineered mouse (GEMM) that forms <i>Brd4::NUTM1</i> gene upon tamoxifen induction <i>Sox2</i>-driven Cre. displayed complete...
<p>Supplementary Fig. S4. Large domains are larger in mNC samples.</p>
<p>Supplementary Fig. S4. Large domains are larger in mNC samples.</p>
<p>Supplementary Fig. S3. mNC-derived cell lines share transcriptional profiles with tumor tissues that are characterized by MYC pathway upregulation.</p>
<p>Supplementary Fig. S2. mNC tumors arise from esophagus.</p>
<div>Abstract<p>NUT carcinoma (NC) is an aggressive squamous defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The lack of adequate animal model precludes identifying and leveraging cell-extrinsic factors therapeutically in NC. Here, we created a genetically engineered mouse (GEMM) that forms <i>Brd4::NUTM1</i> gene upon tamoxifen induction <i>Sox2</i>-driven Cre. displayed complete...