A5068440262- Genetic and phenotypic traits in livestock
- Milk Quality and Mastitis in Dairy Cows
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Animal Genetics and Reproduction
- Plant Pathogens and Resistance
- Effects of Environmental Stressors on Livestock
- Lipid metabolism and biosynthesis
- Potato Plant Research
- Plant Disease Resistance and Genetics
- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
- Reproductive Physiology in Livestock
- Fatty Acid Research and Health
- Genomics, phytochemicals, and oxidative stress
- Infant Nutrition and Health
- Digestive system and related health
- Veterinary medicine and infectious diseases
- Free Radicals and Antioxidants
- Meat and Animal Product Quality
- Animal Virus Infections Studies
- Botanical Research and Chemistry
- Microbial infections and disease research
- Botany and Plant Ecology Studies
FrieslandCampina (Netherlands)
2024
Wageningen University & Research
2012-2022
TiFN
2014-2018
Centre for BioSystems Genomics
2016-2017
Radboud University Nijmegen
1997
AgResearch
1997
Summary Dietary fat may play a role in the aetiology of many chronic diseases. Milk and milk‐derived foods contribute substantially to dietary fat, but have composition that is not optimal for human health. We measured milk samples 1918 Dutch Holstein Friesian cows their first lactation estimated genetic parameters fatty acids. Substantial variation milk‐fat was found: heritabilities were high short‐ medium‐chain acids (C4:0–C16:0) moderate long‐chain (saturated unsaturated C18). genotyped...
Identifying genomic regions, and preferably individual genes, responsible for genetic variation in milk fat composition of bovine will enhance the understanding biological pathways involved fatty acid synthesis may point to opportunities changing via selective breeding. An association study 50,000 single nucleotide polymorphisms (SNPs) was performed even-chain saturated acids (C4:0-C18:0), monounsaturated (C10:1-C18:1), polyunsaturated C18:2cis9,trans11 (CLA) identify regions associated with...
The aim of our study was to estimate effects polymorphisms in the ATP-binding cassette G2 (ABCG2), fatty acid synthase (FASN), oxidized low-density lipoprotein receptor 1 (OLR1), peroxysome proliferator-activated receptor-gamma coactivator-1alpha (PPARGC1A), prolactin (PRL) and signal transducer activator transcription 5A (STAT5A) genes on milk production traits detailed milk-fat composition. Milk-fat composition phenotypes were available for 1905 Dutch Holstein-Friesian cows. First,...
Partners in Expert Working Group WG2 of the COST Action METHAGENE have used several methods for measuring methane output by individual dairy cattle under various environmental conditions. Methods included respiration chambers, sulphur hexafluoride (SF6) tracer technique, breath sampling during milking or feeding, GreenFeed system, and laser detector. The aim current study was to review compare suitability large-scale measurements animals, which may be combined with other databases genetic...
Copy number variation (CNV), which is characterized by large-scale losses or gains of DNA fragments, contributes significantly to genetic and phenotypic variation. Assessing CNV across different European cattle populations might reveal changes responsible for differences, have accumulated throughout the domestication history as consequences evolutionary forces that act upon them. To explore pattern CNVs cattle, we genotyped 149 individuals, represent regions, using Illumina Bovine HD...
The aim of our study was to detect new polymorphisms in the bovine beta-lactoglobulin (beta-LG) gene with significant effects on beta-LG protein concentration. Genomic DNA samples from 22 proven bulls were screened for coding and promoter regions gene. In total, 50 detected. Two single nucleotide (SNPs) (g.1772G>A g.3054C>T) lead amino acid changes are causal genetic variants A B. Forty-two complete linkage disequilibrium (LD) Any these 42 can be involved differential expression respective B...
During secretion of milk fat globules, triacylglycerol (TAG) droplets are enveloped by a phospholipid (PL) trilayer. Globule size has been found to be related polar lipid composition and content, content fatty acid have associated with the diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism; however, association between DGAT1 polymorphism globule not studied. The ratio neutral lipids as well in industrial nutritional health implications. Understanding phenotypic genotypic factors...
In this study we perform a genome-wide association (GWAS) for bovine milk fatty acids from summer samples. This replicates previous where performed GWAS based on winter samples the same population. Fatty and are genetically similar traits therefore compare regions detected in to previously discover that explain genetic variation both milk. The of resulted 51 associated with one or more acids. Results agreement most associations were samples, including eight 'new' not considered individual...
Casein (CN) phosphorylation is an important posttranslational modification and one of the key factors responsible for constructing stabilizing casein micelles. Variation in degree αS-CN great interest because it suggested to affect milk technological properties. This study aimed investigate variation among individual cows explore relationships different isoforms αS-CN. For this purpose, we analyzed morning samples from 529 French Montbéliarde using liquid chromatography coupled with...
Keyhole limpet hemocyanin (KLH)-binding natural antibody (NAb) titers in chickens are heritable, and higher levels have previously been associated with a survival. This suggests that selective breeding for NAb might increase survival by means of improved general disease resistance. Chickens were divergently selected bred total binding KLH at 16 weeks age six generations, resulting High selection line Low line. To test differences resistance, challenged avian pathogenic Escherichia coli...
The power of genome-wide association studies (GWAS) is often limited by the sample size available for analysis. Milk fatty acid (FA) traits are scarcely recorded due to expensive and time-consuming analytical techniques. Combining multi-population datasets can enhance GWAS enabling detection genomic region explaining medium low proportions genetic variation. detect broader regions containing several positional candidate genes making it difficult untangle causative candidates. Post-GWAS...
The aim of this study was to detect new polymorphisms in the bovine β-casein (β-CN) gene and evaluate association (new) β-CN protein variants with milk production traits composition. Screening genomic DNA from 72 Holstein Friesian (HF) bulls resulted detection 19 revealed presence variant I Dutch HF population. Studies composition usually do not discriminate A2. Association studied 1857 first-lactation cows showed that associations A2 were quite different for several traits. significantly...