A5052932039- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Engineering Technology and Methodologies
- Fusion and Plasma Physics Studies
- 3D Printing in Biomedical Research
- Cardiac and Coronary Surgery Techniques
- biodegradable polymer synthesis and properties
- Respiratory Support and Mechanisms
- Orthopaedic implants and arthroplasty
- COVID-19 diagnosis using AI
- Polymer Surface Interaction Studies
- Cardiovascular Disease and Adiposity
Polytechnic University of Turin
2020-2024
Centro Interuniversitario di Ricerca Per lo Sviluppo sostenibile
2024
Adverse remodeling post-myocardial infarction is hallmarked by the phenotypic change of cardiac fibroblasts (CFs) into myofibroblasts (MyoFs) and over-deposition fibrotic extracellular matrix (ECM) mainly composed fibronectin collagens, with loss tissue anisotropy stiffening. Reversing fibrosis represents a key challenge in regenerative medicine. Reliable vitro models human could be useful for preclinical testing new advanced therapies, addressing limited predictivity traditional 2D cell...
In vitro models of pathological cardiac tissue have attracted interest as predictive platforms for preclinical validation therapies. However, reproducing specific features, such fibrosis size (i.e., thickness and width) stage development are missing. This research was aimed at engineering 2D 3D early-stage post-infarct fibrotic characterized by non-aligned organization) on bioartificial scaffolds with biomimetic composition, design, surface stiffness. random nanofibrous structure 150 µm...
Electrospun membranes have been widely used as scaffolds for soft tissue engineering due to their extracellular matrix-like structure. A mussel-inspired coating approach based on 3,4-dihydroxy-DL-phenylalanine (DOPA) polymerization was proposed graft gelatin (G) onto poly(lactic-co-glycolic) acid (PLGA) electrospun membranes. PolyDOPA allowed grafting of PLGA fibers without affecting bulk characteristics, such molecular weight and thermal properties. were dipped in a DOPA solution (2 mg/mL,...
Cardiac infarction is a global burden worldwide that leads to fibrotic and not contractile myocardial tissue. In this work, in vitro models of infarcted tissue were developed as tools test novel therapies for cardiac regeneration the future. Human fibroblasts cultured on scaffolds, with different compositions architectures, mimic structural chemical features Early findings from cell tests reported, showing an enhancement attachment proliferation case “bioartificial” i.e. scaffolds based...