A5035435898- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Protein purification and stability
- Computational Drug Discovery Methods
- Analytical chemistry methods development
- Inorganic and Organometallic Chemistry
- Combustion and Detonation Processes
- Fault Detection and Control Systems
- Safe Handling of Antineoplastic Drugs
- Inhalation and Respiratory Drug Delivery
- Crystallization and Solubility Studies
- biodegradable polymer synthesis and properties
- Microencapsulation and Drying Processes
University of Belgrade
2013-2014
This study had two aims. Firstly, we wanted to model the effects of percentage Eudragit RS PO and compression pressure as most important process formulation variables on time course drug release from extended-release matrix aspirin tablets. Secondly, investigated possibility predicting stability shelf-life using an artificial neural network (ANN). Ten types tablets were prepared formulations stored in chambers at 60 degrees C, 50 40 C 30 controlled humidity. Samples removed predefined points...
In this work behavior of active pharmaceutical substances - methylprednisolone (in a form sodium succinate) in finished dosage freeze dried powder for injections was examined. The goal to evaluate the chemical stabilities succinate packaged dual chamber vial, as specific container closure system. effect different parameters: temperature, moisture and light were monitored. USP method assay used determine concentrations methylprednisolone, sum concentration esters (17-hydrogen 21-hydrogen free...
This article presents the possibility of using multiple regression analysis (MRA) and dynamic neural network (DNN) for prediction stability Hydrocortisone 100 mg (in a form hydrocortisone sodium succinate) freeze-dried powder injection packed into dual chamber container. Degradation products succinate: free related substances (impurities A, B, C, D E; unspecified impurities total impurities) were followed during stress formal studies. All data obtained studies used in silico modeling; models...