A5006085890- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Pharmaceutical studies and practices
- Computational Drug Discovery Methods
- Protein purification and stability
- Drug Transport and Resistance Mechanisms
- Granular flow and fluidized beds
- 3D Printing in Biomedical Research
- Microencapsulation and Drying Processes
- Spectroscopy and Chemometric Analyses
- Powder Metallurgy Techniques and Materials
- Injection Molding Process and Properties
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cyclone Separators and Fluid Dynamics
- Pharmaceutical Economics and Policy
- Antibiotics Pharmacokinetics and Efficacy
- Fluid Dynamics and Mixing
- Surfactants and Colloidal Systems
- Pharmacological Effects and Toxicity Studies
- Biosimilars and Bioanalytical Methods
- Hydrogels: synthesis, properties, applications
University of Belgrade
2015-2024
Deleted Institution
2017-2024
University of Ljubljana
2017
Institut za filozofiju
2016
Pharmaceutical Biotechnology (Czechia)
2009-2011
Implementation of the Quality by Design (QbD) approach in pharmaceutical development has compelled researchers industry to employ Experiments (DoE) as a statistical tool, product development. Among all DoE techniques, response surface methodology (RSM) is one most frequently used. Progress computer science had an impact on well. Simultaneous with implementation methods, machine learning tools took important place drug formulation. Twenty years ago, first papers describing application...
The aim of the present study was to use gastrointestinal simulation technology and in vitro−in vivo correlation (IVIVC) as tools investigate a possible extension biowaiver criteria BCS class II drugs using carbamazepine (CBZ) candidate compound. Gastrointestinal based on advanced compartmental absorption transit model implemented GastroPlus used. Actual vitro data generated CBZ bioequivalence studies were used for purposes. simulated plasma profile, physicochemical pharmacokinetic...
Context: Considering that bitter taste of drugs incorporated in orally disintegrating tablets (ODTs) can be the main reason for avoiding drug therapy, it is utmost importance to achieve successful taste-masking. The evaluation taste-masking effectiveness still a major challenge.Objective: objective this study was mask selected model by particle coating with Eudragit® E PO, as well evaluate prepared ODTs using compendial dissolution testing, small-volume shake-flask assembly and trained human...
Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of forming polymer and dimensions geometry tablets. A complete two-factor, three-level factorial design, followed multiple regression analysis response surface methodology, was applied to investigate influence level tablet size on drug kinetics prepared with Carbopol 971P 71G. Tablet diameter, radius-to-height ratio, area, surface-area-to-volume ratio were evaluated as independent variables in terms...
The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition crosslinking degree find materials satisfactory swelling drug release properties. Samples characterized measuring the behavior in vitro paracetamol as a model aqueous media different pH values. two-factor, three-level experimental design response surface methodology applied statistically evaluate influence factors.
Multiple emulsions are complex dispersion systems which have many potential applications in pharmaceutics, cosmetics and the food industry. In practice, however, significant problems may arise because of their thermodynamic instability. this study, W/O/W multiple emulsion containing low concentration levels lipophilic polymeric primary emulsifiers cetyl dimethicone copolyol PEG-30 dipolyhydroxystearate were evaluated. The concentrations set at 1.6 2.4 % w/w final emulsions. Rheological...
Abstract Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there some reported based on spectrophotometric determinations. However, all these involve extraction or derivatisation procedures. In present study UV spectra investigated samples were recorded over wavelength range 220–400 nm ( λ step 0.21 nm; scan speed 60 nm/min) second‐order derivative...
The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based Carbopol 971P 71G was investigated. A number buffered unbuffered differing with respect to their pH value, ionic strength species evaluated. observed in-vitro profiles were compared the hypothetical in-vivo calculated by numerical deconvolution from results an study. obtained IVIVC plots examined using linear non-linear (proportional odds,...
The Biopharmaceutics Classification System (BCS) represents the framework for predicting intestinal drug absorption based on its solubility and permeability. Recent research has lead to use of <i>in vitro</i> tests waive additional vivo</i> bioequivalence studies some pharmaceutical products (i. e. biowaiver). current regulations permit waivers BCS Class I (highly soluble/highly permeable) substances, which represent up 25 % drugs. Efforts in both science regulatory bodies are being made...