Context: Considering that bitter taste of drugs incorporated in orally disintegrating tablets (ODTs) can be the main reason for avoiding drug therapy, it is utmost importance to achieve successful taste-masking. The evaluation taste-masking effectiveness still a major challenge.Objective: objective this study was mask selected model by particle coating with Eudragit® E PO, as well evaluate prepared ODTs using compendial dissolution testing, small-volume shake-flask assembly and trained human...

Co-processing (CP) provides superior properties to excipients and has become a reliable option facilitated formulation manufacturing of variety solid dosage forms. Development directly compressible formulations with high doses poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains great challenge for the industry due lack understanding interplay between properties, process compaction, stages tablets’ detachment ejection. The aim this study was analyze...

The processing of liquisolid systems (LSS), which are considered a promising approach to improving the oral bioavailability poorly soluble drugs, has proven challenging due relatively high amount liquid phase incorporated within them. objective this study was apply machine-learning tools better understand effects formulation factors and/or tableting process parameters on flowability and compaction properties LSS with silica-based mesoporous excipients as carriers. In addition, results...

Consumption of alcoholic beverages with sustained-release oral dosage forms may pose a risk to patients due potential alcohol-induced dose dumping (ADD). Regulatory guidances recommend in vitro dissolution testing identify the ADD, but question remains whether currently proposed test conditions can be considered biopredictive. The purpose this study was evaluate different setups assess and combined vitro–in silico approach predict drug absorption after concomitant alcohol intake for...

: Improving the production rates of modern tablet presses places ever greater demands on performance excipients. Although co-processing has emerged as a promising solution, there is still lack directly compressible excipients for modified-release formulations. The aim present study was to address this issue by investigating potential novel co-processed manufacture tablets containing ibuprofen.

Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble solution/suspension suitable vehicle. This study addresses lack data regarding compaction behavior liquisolid systems, aim to investigate influence load, carrier coating ratio, type (microcrystalline cellulose vs. spray dried calcium hydrogen phosphate, anhydrous (Fujicalin®)) on flowability and properties determine optimum loads. admixtures...

Liquisolid systems are a novel, promising platform for the production of solid dosage forms with high liquid content, i.e. dispersion drug in suitable, hydrophilic, non-volatile vehicle or drug. This technology requires conventional, but highly porous excipients (carrier and coating material appropriate ratio) able to absorb/adsorb medication, resulting both good flowability acceptable compression properties. approach has shown great potential improve dissolution rate bioavailability poorly...

An understanding of material properties and processing effects on solid dosage forms performance is required within the Quality-by-design approach to pharmaceutical development. Several research groups have developed mathematical approaches aiming facilitate selection formulation composition manufacturing technology. These are based particulate, bulk compression-related properties. This paper provides theoretical assumptions a critical review different for processability characterization...

Hot-melt coating (HMC) is an alternative, solvent-free method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties the coated material. selected substrates included highly soluble sodium chloride (model substance) caffeine (bitter drug), agent glycerol distearate without/with addition liquid paraffin. Experiments with revealed that pan-coating...

Conventional granulation methods are associated with significant disadvantages which have led to increased interest and investment in the development of alternative techniques. Melt is an technique potential for application production solid dosage forms. involves use binders relatively low melting point (50 100°C) that act as a molten binding liquid agglomeration process. Considering solvent not required, drying phase avoided, number processing steps costs reduced comparison traditional wet...

Depression is the most common mental disorder in general population and often requires long-term administration of antidepressants. Development modified release antidepressant products has led to lower incidence adverse effects improvement adherence, subsequently better therapeutic outcomes. Modified may involve delayed and/or prolonged There an increasing number marketed form orally dispersible tablets, for treatment a particular group patients with impaired swallowing. Pharmacotherapy...