A5021207255- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Crystallization and Solubility Studies
- Powder Metallurgy Techniques and Materials
- Granular flow and fluidized beds
- Protein purification and stability
- Microencapsulation and Drying Processes
- Advanced Drug Delivery Systems
- Injection Molding Process and Properties
- Rheology and Fluid Dynamics Studies
- Medicinal Plants and Neuroprotection
- Metal and Thin Film Mechanics
- Cholinesterase and Neurodegenerative Diseases
- Force Microscopy Techniques and Applications
- biodegradable polymer synthesis and properties
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Nicotinic Acetylcholine Receptors Study
- Iron and Steelmaking Processes
- Hydrogels: synthesis, properties, applications
- Structural Engineering and Materials Analysis
- Material Properties and Processing
- Aerogels and thermal insulation
- Advancements in Transdermal Drug Delivery
- Advanced Sensor and Energy Harvesting Materials
University of Ljubljana
2014-2024
Objective: The purpose of this study was to investigate and quantify flow properties, compressibility, compactibility various pharmaceutical lactose powders found on the market today (DCL-11, DCL-21, M‐200, Flowlac-100, Tablettose 70, 80, 100). Methods: Flow properties were estimated by measuring time, angle repose, Hausner ratio. Particle rearrangement studied using Kawakita's linear model. Compressibility two 'out-of-die' methods: (i) Heckel model (ii) a modified Walker Compactibility...
This study investigates the effect of particle size on compression characteristics wet- (fluid-bed granulation - FBG) and dry-granulated (slugging DGS) tableting mixtures. Particle-size distribution, flowability, compressibility, using Heckel Walker model, compactibility elastic recovery as well friability disintegration were determined compared between two fractions (180-400 μm, 400-710 μm) initial unsieved The results showed that granules had no compressibility FBG DGS mixtures, due to...
Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer's disease. Unfortunately, like disease, CCD cannot be cured. In the present study, we treated our newly developed characterized butyrylcholinesterase inhibitor (BChEi). Seventeen were randomized into two groups (treated BChEi untreated) followed for 6 months at regular check-ups. The dogs' status was determined by a Dementia Scale (CADES) questionnaire tests. moderate impairment, treatment...
Self-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations, designed to improve the solubility of poorly-water soluble drugs. Mesoporous silica is frequently used for SMEDDS solidification by various techniques. One them wet granulation, which enables achieving both high load and good flow properties. This study investigated effect six polymeric binders' addition granulation dispersion (GD) (povidone K30, povidone K90, copovidone, Pharmacoat® 603, 615 Methocel™ K100...
Information about flow and compaction properties of hypromellose (HPMC) polymers is essential for the technologists who are facing challenges regarding poor while developing new controlled release matrix tablets. There a profound lack studies in this field none published ones deal with newly introduced HPMC grades specifically designed direct compression (DC).The objective behind study was evaluation six different substitution type 2208 polymers, including two second generation directly...
There is a growing interest in implantable drug delivery systems (DDS) pharmaceutical science. The aim of the present study to investigate whether it possible customize release from DDSs through drug-carrier interactions. Therefore, series chemically similar active ingredients (APIs) was mixed with different matrix-forming materials and then compressed directly. Compression dissolution interactions were examined by FT-IR spectroscopy. Regarding effect on kinetics, custom-made device designed...
Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve solubility poorly water-soluble drugs. They known high liquid load capacity and ability maintain characteristics dry, free-flowing powders. Therefore, five different mesoporous were used preparation carvedilol-loaded SMEDDS granules by wet granulation methods-in paten (manually) using high-shear (HS) granulator. Granules with highest content (63% 66%...
Film coating of pellets is a common way to design modified-release systems. The aim this study was produce multiple-unit tablet compressed from enteric-coated pellets. dosage form should comply with Pharmacopoeial demands, especially regarding dissolution, but preferably also all other parameters, including sufficient hardness for packaging procedures. Various approaches, such as using different cushioning excipients, enteric polymers, changing the shape, and application an additional...
Hot-melt extrusion (HME) is a widely used method for creating amorphous solid dispersions (ASDs) of poorly soluble drug substances, where the molecularly dispersed in polymer matrix. This study examines impact three different copovidone excipients, their reactive impurity levels, HME barrel temperature, and distribution colloidal silicon dioxide (SiO