A5043749066- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Mesoporous Materials and Catalysis
- Crystallization and Solubility Studies
- Protein purification and stability
- Chemical Thermodynamics and Molecular Structure
- Analytical Chemistry and Chromatography
- Pharmaceutical studies and practices
- Adsorption, diffusion, and thermodynamic properties of materials
- Microencapsulation and Drying Processes
- Aerogels and thermal insulation
- Analytical Methods in Pharmaceuticals
- Force Microscopy Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- Inhalation and Respiratory Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Analytical chemistry methods development
- Polymer Surface Interaction Studies
- Clay minerals and soil interactions
- X-ray Diffraction in Crystallography
- Layered Double Hydroxides Synthesis and Applications
- Granular flow and fluidized beds
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
University of Ljubljana
2015-2024
University of Szeged
2022
University of Novi Sad
2022
Weatherford College
2014
University of London
2003
In recent years, a great deal of interest has been focused on the development novel atomic force microscopy (AFM)-based methods. From first being an unstable method, AFM emerged as perfect tool for study phenomena at nanoscale, which includes quantitative single molecule studies. Numerous methods play crucial role in invention drugs, their delivery systems, based either polymers or inorganic/metallic matrices, and examination disease-related tissue changes. Such contemporary progressive...
In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on parameters as tool for predicting the of certain carriers. Solubility were determined two different ways: solely using calculation methods, experimental approaches. Six methods applied order to calculate ibuprofen several...
With the advancement of drug delivery systems based on mesoporous silica nanoparticles (MSNs), a simple and efficient method regulating release kinetics is needed. We developed redox-responsive with three levels hindrance around disulfide bond. A model (rhodamine B dye) was loaded into MSNs' voids. The pore opening capped β-cyclodextrin in order to prevent leakage drug. Indeed, absence reducing agent exhibited little leakage, while addition dithiothreitol cleaved bonds enabled cargo. rate...
To elucidate the importance of size capping agents in stimulus-induced release systems from mesoporous silica nanoparticles (MSNs), effectiveness poly(propylene imine) dendrimers controlling model drug was studied. MCM-41-type MSNs were synthesized and characterized. Fluorescent compounds (fluorescein disodium salt carboxyfluorescein) loaded porous structure entrapped matrix with generations I through V by anchoring on MSN surface disulfide bonds. Stimulus-induced cargo studied presence...
The study aimed to enhance the solubility of poorly water-soluble drug, fenofibrate, by loading it onto mesoporous silica, forming amorphous solid dispersions. Solid dispersions with 30% fenofibrate were prepared using solvent evaporation method three solvents (ethyl acetate, acetone, and isopropanol) at different temperatures (40 °C, boiling point temperature). Various characteristics, including solid-state properties, particle morphology, drug release, evaluated methods compared a pure...
The shape of drug loaded polysaccharide beads produced by ionotropic gelation has been optimized, with the aim producing spherical suitable for further technological operations, such as coating. optimization was performed on a model system sodium alginate/theophylline inclusion various fillers. Incorporation excipients markedly influenced morphological characteristics beads. undesired irregular caused incorporation could only be improved incorporating combination polycarbophil (PK) and...
Fluconazole cocrystals were prepared with the intention to modify physicochemical properties of antifungal agent. The well-known COOH···Narom heterosynthon was considered key element in design strategy. Cocrystals fluconazole maleic, fumaric, and glutaric acid identified solution evaporation experiments pharmaceutically acceptable dicarboxylic acids their crystal structures are presented. Solid-state NMR as an alternative technique for providing structural information offered additional...
The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer evaluate their release properties physiochemical stability. crystallization MCP in the polymer matrix monitored image analysis techniques for rapid scalable observation. results showed that addition protective its thickness significantly affected rate behavior formulations. increased over time, certain higher susceptibility...