Borut Kovačič

ORCID: 0000-0003-3911-2408
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About
Contact & Profiles
Research Areas
  • Reproductive Biology and Fertility
  • Assisted Reproductive Technology and Twin Pregnancy
  • Ovarian function and disorders
  • Reproductive Health and Technologies
  • Reproductive System and Pregnancy
  • Sperm and Testicular Function
  • Endometriosis Research and Treatment
  • Prenatal Screening and Diagnostics
  • Renal and related cancers
  • Drug Solubulity and Delivery Systems
  • Gynecological conditions and treatments
  • Birth, Development, and Health
  • Pluripotent Stem Cells Research
  • Pregnancy and preeclampsia studies
  • Endometrial and Cervical Cancer Treatments
  • Biomedical Ethics and Regulation
  • Microtubule and mitosis dynamics
  • Advanced Drug Delivery Systems
  • Microfluidic and Capillary Electrophoresis Applications
  • Ectopic Pregnancy Diagnosis and Management
  • Anatomy and Medical Technology
  • Crystallization and Solubility Studies
  • Art History and Market Analysis
  • Tissue Engineering and Regenerative Medicine
  • Artificial Intelligence in Healthcare and Education

University Clinical Centre Maribor
2015-2024

University of Maribor
1992-2021

University of Ljubljana
2010-2021

Ljubljana University Medical Centre
2021

European Society of Human Reproduction and Embryology
2015

Krka (Slovenia)
2010-2011

Miwa Hospital
2010

Rigshospitalet
2010

University of Auckland
2010

MRC Centre for Reproductive Health
2010

Abstract STUDY QUESTION What are the data and trends on ART IUI cycle numbers their outcomes, fertility preservation (FP) interventions, reported in 2018 as compared to previous years? SUMMARY ANSWER The 22nd ESHRE report shows a continued increase of treatment cycles children born Europe, decrease transfers with more than one embryo further reduction twin delivery rates (DRs) 2017, higher DRs per transfer after fresh IVF or ICSI (without considering freeze-all cycles) frozen (FET) pregnancy...

10.1093/hropen/hoac022 article EN cc-by Human Reproduction Open 2022-01-01

What recommendations can be provided on the approach to and use of time-lapse technology (TLT) in an IVF laboratory?The present ESHRE document provides 11 how introduce TLT laboratory.Studies have been published clinical embryology. However, a systematic assessment this is currently missing.A working group members Steering Committee Special Interest Group Embryology selected was formed order write practical aspects for laboratory.The included different nationalities with internationally...

10.1093/hropen/hoaa008 article EN cc-by-nc Human Reproduction Open 2020-01-01

Abstract STUDY QUESTION What are the data and trends on ART IUI cycle numbers their outcomes, fertility preservation (FP) interventions, reported in 2019 as compared to previous years? SUMMARY ANSWER The 23rd ESHRE report highlights rising treatment cycles children born, alongside a decline twin deliveries owing decreasing multiple embryo transfers; fresh IVF or ICSI exhibited higher delivery rates, whereas frozen transfers (FET) showed pregnancy rates (PRs), decreased while maintaining...

10.1093/humrep/dead197 article EN cc-by Human Reproduction 2023-10-17

Abstract Endometriosis is a benign disease of the female reproductive tract, characterized by process chronic inflammation and alterations in immune response. It estimated to affect 2–19% women general population commonly associated with symptoms pelvic pain infertility. Regulatory T cells (Treg) are subpopulation lymphocytes that potent suppressors inflammatory response, essential preventing destructive immunity all tissues. In endometriosis, several studies have investigated possible role...

10.1093/humrep/deae103 article EN other-oa Human Reproduction 2024-05-16

The testicular sperm from biopsy and frozen/thawed tissue are frequently immotile. purpose of our retrospective study was to assess the effect short exposure samples with only immotile pentoxifylline (PF)-sperm motility stimulator. In 77 294 (26.2%) ablation/testicular extraction-intracytoplasmic injection (TESA/TESE-ICSI) cycles in patients azoospermia, were found biopsies even after 2 hours incubation medium. These divided into groups. group 1 (cycles between 1999 2001; n = 30), ICSI...

10.2164/jandrol.05079 article EN Andrology 2006-01-02

Aim: To evaluate the impact of a conceptual diagram assessment task on dietetic student knowledge and confidence applying Nutrition Care Process. Methods: Situated within pragmatic research paradigm, this mixed methods study applied survey administered before after using Process to explore changes in knowledge, self-reported confidence, perceptions towards Process, experience. Nineteen students enrolled first-semester unit Master level course completed task, which visually presented client...

10.26890/gpwe3797 article EN 2025-01-31

Vitrified human blastocysts show varied re-expansion capacity after warming. This prospective observational study compared behaviour of artificially collapsed (study group patients, n = 69) to that were vitrified without artificial collapse (control 72). Warmed monitored by time-lapse microscopy and blastocoel speed growth patterns between control groups. These parameters also retrospectively resulted in live birth those failed. Artificially re-expanded on average 15.01 µm2/min faster than...

10.1016/j.rbmo.2017.10.111 article EN cc-by-nc-nd Reproductive BioMedicine Online 2017-11-16

The purpose of this study was to find out the most important prognostic factors for achieving a pregnancy after in vitro fertilization (IVF) women with history repeated unsuccessful IVF attempts.We analyzed affecting rate retrospective including 429 IVF/ICSI cycles performed younger than 40 years at least three previous consecutive failed attempts.Clinical observed 140/429 (32.6%) cycles. Clinical (CPR) significantly higher LEI compared without before embryo transfer (44.4 vs 26.54%, p =...

10.1007/s10815-017-0916-4 article EN cc-by Journal of Assisted Reproduction and Genetics 2017-04-06

Solid dispersion particles of carvedilol (CAR) were prepared with porous silica (Sylysia 350) by the solvent evaporation method in a vacuum evaporator to ensure an effective pore-filling procedure. Two sets prepared, each various amounts CAR solid dispersions, and process differing time. Set A was one-step filling set B multiple-step into silica. The dispersions then characterized using thermal analysis, X-ray diffraction, nitrogen adsorption experiments. results showed that drug release can...

10.1248/cpb.59.427 article EN Chemical and Pharmaceutical Bulletin 2011-01-01

What is the recognition of clinical embryology and current status embryologists in European countries, regarding educational levels, responsibilities workload, need for a formal education assisted reproductive technology (ART)?It striking that profession embryology, almost 40 years after introduction IVF, still not officially recognized most countries.Reproductive medicine has developed into sophisticated multidisciplinary medical branch since birth Louise Brown 37 ago. The Board & College...

10.1093/humrep/dev118 article EN Human Reproduction 2015-06-12

The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in selected genes, responsible for hormonal regulation folliculogenesis, are associated with response controlled ovarian hyperstimulation (COH) and clinical characteristics women enrolled vitro fertilization (IVF) programs.In a cross-sectional study, 60 patients underwent COH by using gonadotropin-releasing hormone (GnRH) antagonist recombinant follicle-stimulating (rFSH) protocol. Patients were...

10.1007/s10815-018-1357-4 article EN cc-by Journal of Assisted Reproduction and Genetics 2018-11-08

To synthesise data from genome-wide studies reporting molecular signature of eutopic endometrium through the phases menstrual cycle in endometriosis.

10.1007/s10815-020-01833-3 article EN cc-by Journal of Assisted Reproduction and Genetics 2020-05-30

Abstract Medical Assisted Reproduction proved its efficacy to treat the vast majority forms of infertility. One key procedures in this treatment is selection and transfer embryo with highest developmental potential. To assess potential, clinical embryologists routinely work static images (morphological assessment) or short video sequences (time-lapse annotation). Recently, Artificial Intelligence models were utilized support procedure. Even though they have proven their great potential...

10.1038/s41597-023-02182-3 article EN cc-by Scientific Data 2023-05-11

The microtubules and chromosomes of 180 human oocytes failing to fertilize after intracytoplasmic sperm injection were observed in order establish how chromatin astral microtubule configuration is related the phases oocyte cell cycle, find defects those structures causing fertilization arrest. As many as 125 (69%) arrested at metaphase II. In one-fourth them, damages second meiotic spindle noted. their cytoplasm intact found 38 (30%) cases, a swollen head 36 (29%) prematurely condensed...

10.1002/(sici)1098-2795(200002)55:2<197::aid-mrd9>3.0.co;2-q article EN Molecular Reproduction and Development 2000-02-01

At the Centre for Geodesy of University Maribor, Slovenia, we engaged in measurement and analysis displacements last ten years. We wanted to find connections between applied loads. Therefore, reliable accurate results were needed. A reinforced-concrete plate was loaded 42 kN pre-calculated steps resulting deformations measured by three independent methods. The compared analytical ones. analyses calculations most suitable method implemented. An electronic tacheometer, photogrammetry a...

10.1179/003962611x12894696204902 article EN Survey Review 2011-03-21

Anti-Müllerian hormone (AMH) is a marker of the ovarian reserve with promising prognostic potential in reproductive medicine. We aimed to evaluate ability AMH for predicting excessive or poor responses stimulation using gonadotrophin-releasing (GnRH) agonist and GnRH antagonist protocols patients undergoing medically assisted reproduction (MAR) procedures. This retrospective analysis included 623 women who underwent reproduction. level measurements were acquired from all couples within six...

10.1186/s12958-015-0049-5 article EN cc-by Reproductive Biology and Endocrinology 2015-06-10
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