Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, polymer films, among these possible systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused formulating buccal films investigating physical physical–chemical properties of films. Sodium alginate (SA) hydroxypropyl methylcellulose (HPMC) were used film-forming agents, glycerol (GLY)...

Background: Captopril (CAP), an angiotensin-converting enzyme inhibitor (ACEI), is widely prescribed for managing hypertension, heart failure, and related conditions. When administered orally, CAP undergoes hepatic metabolism, resulting in a bioavailability of 60–75%. However, to bypass the first-pass metabolism other limitations oral route, mucoadhesive buccal films have gained attention as promising alternative with several advantages. The aim this work was formulation optimization...

For many years, researchers have been making efforts to find a manufacturing technique, as well drug delivery system, that will allow for oral of biopharmaceuticals their target site action without impairing biological activity. Due the positive in vivo outcomes this formulation strategy, self-emulsifying systems (SEDDSs) intensively studied last few years way overcoming different challenges associated with macromolecules. The purpose present study was examine possibility developing solid...

Buccal drug administration is a less explored area, therefore researchers and companies focus on its research because of innovative potential opportunities. polymer films (patches) are considered to be an form have great number advantageous properties. Firstly, patients who suffer from swallowing problems children can also apply them. The active pharmaceutical ingredient enters the systemic circulation directly without degradation transformation. aim this study was formulate buccal with...

Nowadays, the buccal administration of mucoadhesive films is very promising. Our aim was to prepare ascorbic acid-containing chitosan study properties and structures important for applicability optimize composition. During formulation films, as polymer basis film used. Ascorbic acid, which provided acidic pH, used in different concentrations (2-5%). The were formulated by solvent casting method. investigated, such physical parameters, force, surface free energy, breaking strength. fine...

Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and also used geriatrics paediatrics. In our earlier work, we successfully formulated buccal which contained cetirizine-hydrochloride (CTZ) the API. The present study focused on investigating stability permeability of prepared films. films was studied with an accelerated test. During test, thickness, breaking hardness vitro mucoadhesivity were...

There is a growing interest in implantable drug delivery systems (DDS) pharmaceutical science. The aim of the present study to investigate whether it possible customize release from DDSs through drug-carrier interactions. Therefore, series chemically similar active ingredients (APIs) was mixed with different matrix-forming materials and then compressed directly. Compression dissolution interactions were examined by FT-IR spectroscopy. Regarding effect on kinetics, custom-made device designed...

The preparation of pellets using a high-shear granulator in rapid single-step is considered good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet qualities, successful optimization plays vital role producing dosage forms with required critical quality attributes. This study was aimed at development pelletization technique Pro-CepT granulator. According by design (QbD) screening results, chopper speed, volume...

Parkinson's disease (PD) is neurodegenerative chronic illness which affects primarily the elderly over 45 years of age. The symptoms can be various, both non-motor and motor appear. biggest problem in treatment difficulty swallowing for patients. However, buccal patches solve this because patients do not have to swallow dosage form, during application, API absorb from area mucosa quickly without causing a foreign body sensation. In our present study, we focused on development polymer films...

In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is novelty there no literature on the use SP in mucoadhesive films. Films containing were prepared at different temperatures, with concentrations and lengths hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, vitro properties films investigated. Tensile strength force measured device software developed Institute. Positron...

Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives develop and optimize chitosan-based mucoadhesive by relying on quality-by-design (QbD) principles. Previous knowledge experience were employed firstly identify critical quality attributes (CQAs), followed a thorough risk assessment, which led selection of seven material process parameters, namely, polymer grade concentration,...

The objective of this study was to evaluate the spreading coating liquid on different tablets containing pancreatin and microcrystalline cellulose. effects ratio components, presence magnesium stearate blending circumstances were investigated. contact angle liquids did not change linearly. For mixture 50% pancreatin, deviation measured value from predicted one more than 25%. This deterioration also detected for mixtures 1% lubricant, but extent lower modified by mixing circumstances....

The present work aimed to investigate the impact of critical material attributes on design space production lysozyme pellets with suitable biological and physical properties for subsequent coating process.The effect two brands both conformation stabilizing mannitol behavior composition in an extrusion/spheronization process was studied, while experiments were designed according 2 3 factorial design.The kneading mass carried out a high shear granulator equipped specially granulation chamber...

In our study, core-shell nanoparticles containing lysozyme were formulated with precipitation and layering self-assembly. Factorial design (DoE) was applied by setting the process parameters during preparation Quality Design (QbD) approach. The factors concentration of sodium alginate, pH. Our aim to understand effect through determination mathematical equations, based on which optimization can be predicted under different parameters. encapsulation efficiency, particle size, enzyme activity...

The main aim of this study was to investigate the effects pharmaceutical technological methods on pepsin activity during formulation solid dosage forms. circumstances direct compression and wet granulation were modeled. During compression, heat force must be taken into consideration. these parameters investigated in three materials (pure pepsin, 1:1 (w/w) pepsin–tartaric acid pepsin–citric powder mixtures). It concluded that is appropriate for forms containing through application without...