A5066724259- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Analytical Methods in Pharmaceuticals
- RNA Interference and Gene Delivery
- Pharmaceutical studies and practices
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- Lipid Membrane Structure and Behavior
- Endodontics and Root Canal Treatments
- Advanced biosensing and bioanalysis techniques
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Glaucoma and retinal disorders
- 3D Printing in Biomedical Research
- Oral microbiology and periodontitis research
- Respiratory and Cough-Related Research
- Pharmacy and Medical Practices
- Dendrimers and Hyperbranched Polymers
- Dental Radiography and Imaging
- Neurological Disorders and Treatments
- Essential Oils and Antimicrobial Activity
University of Sarajevo
2014-2024
Saints Cyril and Methodius University of Skopje
2020
MIT University
2020
Universitat de València
2003
For many years, researchers have been making efforts to find a manufacturing technique, as well drug delivery system, that will allow for oral of biopharmaceuticals their target site action without impairing biological activity. Due the positive in vivo outcomes this formulation strategy, self-emulsifying systems (SEDDSs) intensively studied last few years way overcoming different challenges associated with macromolecules. The purpose present study was examine possibility developing solid...
In this study solid dispersions of carbamazepine in the hydrophilic Kollidon® VA64 polymer, adsorbed onto Neusilin® UFL2 adsorption carrier have been employed to improve dissolution rate. order evaluate effects changing proportions all dispersion components on rate, D-optimal mixture experimental design was used formulation development. From prepared formulations, significantly faster observed compared pure drug. Ternary containing carbamazepine, and showed superior performances over binary...
Most pharmaceutical formulations also include a certain amount of lubricant to improve their flowability and prevent adhesion the surfaces processing equipment. Magnesium stearate is an additive that most frequently used as lubricant. capable forming films on other tablet excipients during prolonged mixing, leading drug liberation time, decrease in hardness, increase disintegration time. It hydrophobic, there are many reports literature concerning its adverse effect dissolution rates. The...
There are numerous methods of administering drugs to the body, both passive and active. Active include use penetration enhancers assisted drug delivery. One them is sonophoresis (phonophoresis). This term used describe effects ultrasound on movement through intact living skin into soft tissues. Although exact mechanism not known, absorption may involve a disruption stratum corneum lipids allowing pass skin. In future, release systems aided by be able provide slow vaccines. Researchers...
Although miRNA-27a has been identified as a promising candidate for miRNA mimic therapy of obesity, its application is limited due to enzymatic degradation and low membrane permeation. To overcome these problems, we developed cationic nanostructured lipid carriers (cNLCs) using high-pressure homogenization used them non-viral the anti-adipogenic miRNA-27a. Cargo-free octadecylamine-containing NLCs miRNA/cNLC complexes were characterized regarding particle size, size distributions, zeta...
Dimenhydrinate (DMH), used to alleviate motion sickness symptoms such as nausea, vomiting, dizziness, and vertigo, encounters limitations in oral pharmaceutical formulations due its poor water solubility bitter taste. Our research hypothesized that inclusion complexation with β-cyclodextrin (β-CD) might address these drawbacks while ensuring the newly formed complexes exhibit no cytotoxic or genotoxic effects on peripheral blood mononuclear cells (PBMCs). Inclusion were prepared using...
Dose-related adverse effects of medications are a major problem in modern medical practice. The "correct" dose, based on drug company guidelines package inserts, may not be correct for many patients. Tablet splitting or dividing has been an accepted practice years as means obtaining the prescribed dose medication. As model tablets this investigation, two batches lisinopril- hydrochlorothiazide scored labeled to contain 20/12.5 mg were used. aim study was establish possible influence tablet...
Anthocyanins are effective antioxidants but they have also been proposed to other biological activities independent of their antioxidant capacities that produce health benefits. Examples range from inhibition cancer cell growth in vitro, induction insulin production isolated pancreatic cells, reduction starch digestion through a-glucosidase activity, suppression inflammatory responses as well protection against age-related declines cognitive behavior and neuronal dysfunction the central...
Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, low aqueous solubility and membrane permeability. The bioavailability of such drug limited dissolution rate. present study deals with formulations immediate release tablets poorly soluble carbamazepine. As model for this investigation, two (named "A" "B" formulations) carbamazepine labeled contain 200 mg were evaluated. aim was establish possible differences in...
The objective of this work was to compare several profiles dissolution data for metoprolol controlled release tablet formulations in order identify possible changes whole and scored tablets. Adequate design score lines (on one or both sides) as well the technology preparation mixtures ensure forming a line adequate thickness, shape, size, curvature. According obtained results, type extended formulation is eligible splitting use therapy either
When considering single-dose preparations, it is fundamental that the patient receives in his individual dose an amount of drug close to claimed on label. Since content and uniformity preparations depend a number processes associated with their manufacture, obviously unrealistic expect every unit product possess exactly same active ingredient. For reason, pharmacopeial standards specifications have been established provide limits for permissible variations ingredient units. The aim our study...
Oral administration of indomethacin has been limited by its poor water solubility. Cyclodextrins have recognized as potential candidates to overcome the solubility through formation inclusion complexes. The aim our study was compare dissolution profiles pure and mixtures with α- γ-cyclodextrins complexes were prepared direct mixing in vessel. Fixed volumes medium withdrawn at 0,5; 1 4 hours. Dissolution tests performed on USP Apparatus 2, rotating speed 100 rpm 37±0.5 ° C, 500 ml, distilled...