A5046605119- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
- Crystallization and Solubility Studies
- Glaucoma and retinal disorders
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- 3D Printing in Biomedical Research
- Gastroesophageal reflux and treatments
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Skin Protection and Aging
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Neurological Disorders and Treatments
- Proteins in Food Systems
- Synthesis and Characterization of Heterocyclic Compounds
- Nanocomposite Films for Food Packaging
- Advanced Sensor and Energy Harvesting Materials
- Microencapsulation and Drying Processes
- Synthesis and biological activity
- Circadian rhythm and melatonin
- Pickering emulsions and particle stabilization
- Silymarin and Mushroom Poisoning
University of Sarajevo
2012-2024
The solubility enhancement of diazepam and nitrazepam in water was analyzed depending on temperature amount α-cyclodextrin ( α-CD), β-cyclodextrin (β-CD) 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD). interactions drug-cyclodextrin solution were investigated by the phase-solubility analysis. Diazepam (nitrazepam) content aqueous complexation medium UV spectrophotometrically. Classical data used to derive apparent stability constants (K1:1) which thermodynamic parameters for...
Dimenhydrinate (DMH), used to alleviate motion sickness symptoms such as nausea, vomiting, dizziness, and vertigo, encounters limitations in oral pharmaceutical formulations due its poor water solubility bitter taste. Our research hypothesized that inclusion complexation with β-cyclodextrin (β-CD) might address these drawbacks while ensuring the newly formed complexes exhibit no cytotoxic or genotoxic effects on peripheral blood mononuclear cells (PBMCs). Inclusion were prepared using...
The kinetics of passive transport ketoprofen and metformin, as model substances for high low permeability, respectively, across the artificial membrane under influence pH donor solution was investigated. There an upward trend in apparent permeation coefficient (Papp) with decrease to a value close pKa. At below pKa had lower value, due higher retention membrane. Metformin is permeable compound, highest values were recorded at 7.4. Two dissociation constants determine that metformin...
Abstract Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities amounts on characteristics orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as film-forming polymer 1% w/w glycerol a plasticizer. Films produced through solvent casting method, rendering them suitable for convenient application in community or hospital pharmacy settings. The physicochemical optical properties films analyzed,...
Paediatric and geriatric populations, as well other special patient populations with swallowing problems, require patient-tailored dosage forms. One promising form for these specific is orodispersible films.<br /> When preparing films using sodium carboxymethyl cellulose the film-forming polymer glycerine plasticizer, it essential to determine optimal mixing time speed of casting solution achieve desired transparency/opacity films. In this paper, primary focus on speed, determining how...
In the reaction of 3-aminothymoquinone and aromatic aldehydes, two benzoxazole derivatives viz. 2-(4-methoxyphenyl)-4-methyl-7-isopropyl-1,3-benzoxazol-5-ol (1) 2-(4-trifluoromethyl)-4-methyl-7-isopropyl-1,3-benzoxazol-5-ol (2) were prepared characterized by elemental analysis, infrared 1H, 13C-nuclear magnetic resonance spectroscopy mass spectrometry. Their antimicrobial activity against Escherichia coli, Salmonella enterica, Proteus hauseri, Pseudomonas aeruginosa, Staphylococcus aureus,...
Although homeostasis is a commonly accepted concept, there incontrovertible evidence that biological processes and functions are variable variability occurs in cycles. In order to explain understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model emerged as first serious challenge homeostasis, going beyond its roots. Circadian rhythm predominant variation body, it pattern according many physiological pathological events occur. As strong experimental...
To examine the influence of vehicles on stability extemporaneous suspensions proton pump inhibitors (PPIs), to single out formulation most suitable for children, providing appropriate evidence and arguments.A review was performed data identified from Medline, Embase, Science Direct, as well public digital archive PubMed, including reference texts, related field testing PPI suspensions.Fourteen selected formulations are presented discussed. Depending vehicle its composition, which analyzed...
Since glaucoma is a serious health problem, numerous therapeutics are being developed to reduce Intraocular Pressure (IOP) as the only modifiable factor of all symptoms. IOP-lowering agents divided into six groups, each which has specific mechanism action and side effects, focus this article explained in detail. All mentioned formulated eye drops. However, conventional topical drops have significant disadvantages, poor bioavailability patient noncompliance main, novel approaches designing...