A5055782758- Scientific Computing and Data Management
- dental development and anomalies
- Cancer-related gene regulation
- Research Data Management Practices
- FinTech, Crowdfunding, Digital Finance
- Sharing Economy and Platforms
- Oral and Maxillofacial Pathology
- Genetics, Bioinformatics, and Biomedical Research
- Technology Adoption and User Behaviour
- RNA regulation and disease
- Biomedical Text Mining and Ontologies
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- Academic Publishing and Open Access
- Distributed and Parallel Computing Systems
- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Digital Economy and Work Transformation
- Iron Metabolism and Disorders
- Poetry Analysis and Criticism
- Race, Genetics, and Society
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Environmental Monitoring and Data Management
- Membrane Separation and Gas Transport
European Bioinformatics Institute
2020-2021
Wellcome Trust
2020
Public Library of Science
2016
RELX Group (Netherlands)
2005
King's College London
1999-2004
RELX Group (United Kingdom)
2004
Guy's Hospital
1997-2001
St Thomas' Hospital
1999
King's College Hospital
1999
Baylor College of Medicine
1998
ABSTRACT The molecular events of odontogenic induction are beginning to be elucidated, but until now nothing was known about the basis patterning dentition. A role for Dlx-1 and Dlx-2 genes in dentition has been proposed with envisaged as participating an ‘odontogenic homeobox gene code’ by specifying molar development. This proposal based on restricted expression ectomesenchyme derived from cranial neural crest cells prior tooth initiation. Mice targeted null mutations both do not develop...
Development of the mammalian tooth has been intensively studied as a model system for epithelial/mesenchymal interactions during organogenesis, and progress made in identifying key molecules involved this signaling. We show that activin βA is expressed presumptive tooth-germ mesenchyme thus candidate signaling molecule development. Analysis development mutant embryos shows incisor mandibular molar teeth fail to develop beyond bud stage. Activin an essential component maxillary molars,...
The cellular origin of the instructive information for hard tissue patterning jaws has been subject a long-standing controversy. Are cranial neural crest cells prepatterned or does epithelium pattern developmentally uncommitted population ectomesenchymal cells? In order to understand more about how orofacial is controlled we have investigated temporal signalling interactions and responses between mesenchymal in mandibular maxillary primordia. We show that within arch, homeobox genes are...
Abstract Europe PMC (https://europepmc.org) is a database of research articles, including peer reviewed full text articles and abstracts, preprints - all freely available for use via website, APIs bulk download. This article outlines new developments since 2017 where work has focussed on three key areas: (i) added to its core content include life science preprint abstracts special collection COVID-19-related preprints. unique as an aggregator biomedical alongside peer-reviewed with over 180...
The gene for activin βA is expressed in the early odontogenic mesenchyme of all murine teeth but mutant mice show a patterning defect where incisors and mandibular molars fail to develop maxillary normally. In order understand why molar tooth development can proceed absence activin, we have explored role mediators signalling development. Analysis receptor II Smad2 mutants shows that similar phenotype be observed. addition, identify novel downstream target signalling, Iroquois-related...
ABSTRACT Clim-2 (NLI, Lbd1) is one of two related mouse proteins that interact with Lim-domain homeoproteins. In the mouse, embryonic expression particularly pronounced in facial ectomesenchyme and limb bud mesenchyme association Lim genes, Lhx-6 Lmx-1 respectively. We show common both these regulated by signals from overlying epithelium. developing face buds we identify Fgf-8 as likely candidate signalling molecule regulates expression. mandibular arch, limb, functions combination CD44, a...
On January 20 and 21, 2020, ASAPbio, in collaboration with EMBL-EBI Ithaka S+R, convened over 30 representatives from academia, preprint servers, publishers, funders, standards, indexing metadata infrastructure organisations at (Hinxton, UK) to develop a series of recommendations for best practices posting linking preprints the life sciences ideally broader research community. We hope that these offer guidance new platforms projects looking enact ultimately serve improve experience using all.
We have previously proposed that the patterning of mammalian dentition is determined by an odontogenic homeobox code, whereby positional specification ectomesenchymal cell populations in a given region first branchial arch are combination different genes expressed, described detail (1). Here we describe functional evidence for such mechanism, and show development types teeth controlled independent genetic pathways. suggest mechanism position dependent control tooth germ initiation, propose...
The main focus of this deliverable is the different approaches to provenance as understood, expressed, and implemented by FREYA disciplinary partners in their various pilot applications. presentations here outline general particular research context each organisation, current future implementations, describe activities that are supported persistent identifiers.
A comprehensive survey of the landscape persistent identifiers across many disciplines is presented, with assessments maturity different PID types and conclusions for future. [Revised version]