A5076892693- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Virus-based gene therapy research
- Influenza Virus Research Studies
- Metal complexes synthesis and properties
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Chemotherapy-induced organ toxicity mitigation
- Blood Coagulation and Thrombosis Mechanisms
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Pharmacy and Medical Practices
- Histone Deacetylase Inhibitors Research
- Animal Genetics and Reproduction
- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
Nagasaki Rousai Hospital
2023
Kobe Rosai Hospital
2015-2021
Japan Organization of Occupational Health and Safety
2021
Shionogi (Japan)
1998-2004
Futaba (Japan)
1998
Jichi Medical University
1997
Jichi Medical University Hospital
1997
American Red Cross
1991
Osaka University
1984-1988
Fukushima Medical University
1986-1988
Various N-sulfonylamino acid derivatives were synthesized and evaluated for their in vitro vivo activities to inhibit type IV collagenase (MMP-9 MMP-2). When the amino residue sulfonamide moiety modified, inhibitory greatly affected by structure of moiety. A series aryl containing biaryl, tetrazole, amide, triple bond found be potent highly selective inhibitors MMP-9 MMP-2. In addition, these compounds orally active animal models tumor growth metastasis. These results revealed potential as a...
Abstract The present study determines the Ly phenotype of T cells mediating tumor cell rejection in vivo and investigates some cellular mechanisms involved protective immunity. C3H/HeN mice were immunized to syngeneic X5563 plasmacytoma by intradermal (i.d.) inoculation viable cells, followed surgical resection tumor. Spleen from these immune fractionated treatment with anti-Lyt antibodies plus complement, each Lyt subpopulation was tested for reconstituting potential immunity cell-depleted...
We have devised a new drug screening assay to discover anti-cancer drugs which inhibit Ras-mediated cellular signals, by utilizing Ras-responsive element (RRE)-driven reporter gene system. found that hypothemycin, an anti-bacterial, reduces RRE-dependent transcription. Treatment of tumor cells with hypothemycin resulted in reduced expression Ras-inducible genes, including MMP (matrix metalloproteinase)-1, MMP-9, transforming growth factor-beta (TGF-beta), and vascular endothelial factor...
A common feature of demyelinating diseases such as multiple sclerosis in humans and experimental autoimmune encephalomyelitis rodents is the marked elevation expression major histocompatibility complex (MHC) antigens involved sites. By specific targeting a syngeneic MHC class I gene to oligodendrocytes, we have generated transgenic mice which not only exhibit severe involuntary tremors develop tonic seizures but also show extensive demyelination both brain spinal cord. The fact that these...
The antitumor activities of an angiogenesis inhibitor, (3R,4S,5S,6R)-5- methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)-oxiranyl]-1- oxaspiro[2,5]oct-6-yl(chloroacetyl) carbamate (TNP-470), administered s.c., i.v. and intra-arterially using a chemoembolization technique, were examined in rabbits bearing VX-2 carcinoma. Repeated s.c. injection TNP-470 aqueous solution clearly inhibited the tumor growth proportion to dose, improved efficacy was obtained with once week administration...
Pregnant women are in the highest priority group for receiving influenza vaccination. However, they may be reluctant to receive vaccination due concerns about influence of on fetuses.This prospective cohort study 10 330 pregnant examined safety terms adverse birth outcomes. Influenza during pregnancy was determined from questionnaires before and after 2013/2014 season. All subjects were followed until end their pregnancy. Adverse outcomes, including miscarriage, stillbirth, preterm birth,...
To clarify the pathogenesis of insulitis in nonobese diabetic (NOD) mouse, an animal model for human insulin-dependent diabetes mellitus, T-lymphocyte-depleted NOD mice (B mice) were adoptively transferred with spleen and lymph node cells from cyclophosphamide-treated after separating monoclonal antibodies against various T-lymphocyte surface antigens plus complement. Light-microscopic immunohistochemical studies also performed to investigate lymphocytic infiltrations. The incidence detected...
Infants <6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications.To examine the effectiveness maternal vaccination in preventing their infants, we conducted a prospective cohort study 3441 infants born participating hospitals before 2013-2014 season. At time recruitment, mothers completed questionnaire about status A follow-up survey was after end season collect information regarding diagnosis and hospitalization among...
The antitumor effect of a new matrix metalloproteinase inhibitor, MMI-166, which is selective inhibitor MMP-2 and -9, was examined in the hamster pancreatic cancer cell line PGHAM-1. In vitro, MMI-166 inhibited gelatinase activity -9 derived from PGHAM-1 cells, dose-dependently invasion through basement membrane-like barrier. showed no apparent cytotoxicity to cells culture at 100 μg/ml. (200 mg/kg) or vehicle were administered orally, once daily, day 1 until 21 after implantation orthotopic...
Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage dabigatran over WF that monitoring not required; however, a method monitor effect and safety currently available. Global Thrombosis Test (GTT) novel assess both clot formation lysis activities under physiological conditions.The aim this study was evaluate whether treatment might affect shear-induced thrombi (occlusion time [OT], sec) by...
Objective Karoshi, which is the Japanese term for death from over-work, usually extreme result of cardiovascular diseases, and occupational stress plays a pivotal role in pathogenesis. Depression closely associated with atherosclerotic disease. The present study was undertaken to examine relationship between depression. Methods We enrolled 231 consecutive outpatients lifestyle-related diseases such as diabetes, hyperlipidemia hypertension were enrolled. Occupational measured by qualitative...
Abstract The present study investigates the mechanisms of recognition tumor antigens by L3T4+ helper T cells responsible for generation Lyt-2+ cytotoxic lymphocytes (CTL) against a major histocompatibility complex (MHC) Class II (1a) antigen-negative syngeneic X5563 plasmacytoma. Treatment X5563-immunized spleen with anti-L3T4 antibody plus complement (C) diminished anti-X5563 CTL. Since contribution was completely replaced addition exogenous lymphokines, it demonstrated that functioned as...
The regulated expression of major histocompatibility complex class I antigens is essential for assuring proper cellular immune responses. To study H-2 gene regulation, we have transferred a foreign to inbred mice and previously shown that the heterologous was expressed in tissue-dependent manner. In this report, demonstrate these transgenic molecule on cell surface without any alteration level endogenous antigens. Skin grafts from were rapidly rejected by background strain, indicating...
The function of a transgenic Dd class I molecule in the induction immunologic tolerance to major histocompatibility complex antigens and directing restriction C57BL/6 mice were investigated. All mouse strains found be tolerant for antigen. Spleen cells from immunocompetent but consistently failed generate an anti-Dd cytotoxic T lymphocyte response vitro, skin grafts between not rejected. These data suggests that antigen was recognized as self molecule. In addition, generated antigen-specific...