A5042852708- Neural Networks and Applications
- Reproductive Biology and Fertility
- Fault Detection and Control Systems
- Ovarian function and disorders
- Fuzzy Logic and Control Systems
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Control Systems and Identification
- Sperm and Testicular Function
- Structural Health Monitoring Techniques
- Face and Expression Recognition
- AI in cancer detection
- Anesthesia and Pain Management
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Laser Design and Applications
- Endometriosis Research and Treatment
- Blind Source Separation Techniques
- Reservoir Engineering and Simulation Methods
- Geothermal Energy Systems and Applications
- Ectopic Pregnancy Diagnosis and Management
- Estrogen and related hormone effects
- Railway Engineering and Dynamics
- Reliability and Maintenance Optimization
- Laser-Matter Interactions and Applications
University of Sheffield
2015-2024
University of Washington
2017
University of Huddersfield
2016
Rotunda Hospital
1997-2011
Sheffield Teaching Hospitals NHS Foundation Trust
2011
Royal College of Surgeons in Ireland
1991-2010
Trinity College Dublin
1980-2009
St. James's Hospital
1985-2009
St. Patrick's Hospital
2009
Vehicle Technologies Office
2009
TSH is known to have a circadian rhythm, but the relationship between this and any rhythm in T(4) T(3) has not been clearly demonstrated.With view optimizing thyroid hormone replacement therapy, we used modern assays for free (FT4) (FT3) investigate rhythmicity.The study was performed at university hospital.This cross-sectional 33 healthy individuals with 24-h blood sampling (TSH FT4 FT3 29 individuals) cosinor analysis.Of individuals, 100% showed sinusoidal signal TSH, 76%, 86% (P < 0.05)....
Genomic imprinting is an epigenetic process in which allele-specific gene expression dependent on the parental inheritance. Although only a minority of human genes are imprinted, those that have been identified to date preferentially implicated prenatal growth and neurodevelopment. Mutations or epimutations imprinted control centres associated with disorders such as Angelman syndrome (AS) Beckwith–Wiedemann (BWS). Recently, increased frequency assisted reproductive technology (ART)...
Abstract Context: Measuring serum cortisol to evaluate stress, adrenal disease, and monitor hydrocortisone replacement requires venepuncture. Conversely, salivary measurements are noninvasive. Objective: This study aimed investigate measurement of cortisone as alternatives cortisol. Design Setting: was a prospective cross-over in clinical research facility. Patients Methods: Over three periods (Period 1, 24-h physiological rhythm; Periods 2 3, after 20 mg oral iv hydrocortisone) 14 male...
<h3>BACKGROUND</h3> Ear thermometers are becoming popular as a method for measuring deep body (core) temperature. <h3>AIM</h3> To determine the variability of single user's tympanic membrane (ear) temperature measurements. <h3>SUBJECTS</h3> Forty two, afebrile, healthy children, and 20 febrile children with acute burns. <h3>RESULTS</h3> In afebrile measurements made in both ears (and within just few minutes each other) differed by much 0.6°C. Operator measurement error, s<sub>w</sub> three...
One hundred and eighty one primigravid women delivering vaginally in July August 1982 the Rotunda Hospital, Dublin, were randomly allocated to of two groups. Patients group undergo episiotomy. Those other not episiotomy unless it was considered be essential. The outcome compared with that clinical practice over previous six months at hospital. Of 92 patients episiotomy, seven (8%) had done for medical reasons 507 (89%) months. First degree tears occurred 23 (25%) second 43 (47%). Nineteen...
Adrenal incidentalomas (AIs) are found commonly on axial imaging. Around 30% exhibit autonomous cortisol secretion (ACS) associated with increased cardiovascular events and death. We hypothesized that AI/ACS patients have an abnormal rhythm could be reversed by use of carefully timed short-acting synthesis blockade, improvement in disease markers. In a phase 1/2a, prospective study (Eudract no. 2012-002586-35), we recruited six two control groups sex-, age-, body mass index–matched...
Support vector machines (SVM) are used for system identification of both linear and nonlinear dynamic systems. Discrete time models to illustrate parameter estimation demonstrate model structure identification. The VC-dimension a trained SVM indicates the accuracy without using separate validation data. We conclude that have potential in field identification, but there number significant issues be addressed.
The aim of this study was to determine which, and how many, data items are required construct a decision support algorithm for early diagnosis acute myocardial infarction using clinical electrocardiographic available at presentation. Logistic regression models were derived from 600 consecutive patients one centre (Edinburgh), then tested prospectively on 510 cases the same 662 another (Sheffield). Although performance increased with progressive addition inputs when applied training data,...
Analgesic effect, labor outcome, safety and consumer satisfaction were compared in 170 primigravid women; 50 using TENS initially for pain relief, 20 entonox, pethidine + promazine lumbar epidural. 88% choosing epidural related it fully effective. 90% 96% 54% given found partial relief. 82% of patients 80% required additional analgesia. This was also needed by one the entonox. Women entonox alone had shortest labors women epidural, longest. Operative delivery significantly more common...
Objectives The treatment goal in congenital adrenal hyperplasia (CAH) is to replace glucocorticoids while avoiding androgen excess and iatrogenic Cushing's syndrome. However, there no consensus on how monitor disease control. Our main objectives were evaluate hormonal circadian rhythms use these profiles identify optimal monitoring times novel biomarkers CAH adults intermediate- long-acting glucocorticoids. Design This was an observational, cross-sectional study at the National Institutes of...