A5064380046- Lanthanide and Transition Metal Complexes
- Electron Spin Resonance Studies
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Magnetism in coordination complexes
- Advanced MRI Techniques and Applications
- Bioinformatics and Genomic Networks
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Machine Learning in Healthcare
- Bone and Joint Diseases
- Advanced Neuroimaging Techniques and Applications
University of Helsinki
2015-2019
Abstract Identifying individuals at high risk of chronic diseases via easily measured biomarkers could improve public health efforts to prevent avoidable illness and death. Here we present nuclear magnetic resonance blood metabolomics from half a million samples three national biobanks. We built metabolomic scores that identify high-risk group for each 12 cause the most morbidity in high-income countries show consistent cross-biobank replication relative disease these groups. are more...
Identifying individuals at high risk of chronic diseases via easily measured biomarkers could enhance efforts to prevent avoidable illness and death. Using 'omic data can stratify for many simultaneously from a single measurement that captures multiple molecular predictors risk. Here we present nuclear magnetic resonance metabolomics in blood samples 700,217 participants three national biobanks. We built metabolomic scores identify high-risk groups cause the most morbidity high-income...
Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized their stabilities enhancing properties tested with <italic>in vitro</italic> NMR MRI experiments.
Cancer is a widespread and life-threatening disease its early-stage diagnosis vital. One of the most effective, non-invasive tools in medical diagnostics magnetic resonance imaging (MRI) with aid contrast agents. Contrast agents that are currently clinical use contain metals, causing some restrictions their use. Also, these mainly non-specific without any tissue targeting capabilities. Subsequently, interest has notably increased research organic, metal-free This study presents new, stable...
Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used based on paramagnetic metals and lack in selectivity specificity. A group of stable organic radicals, nitroxides, has raised interest as new metal-free for MRI. Their structures can easily be modified incorporate different functionalities. In present study, a nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked glucose moiety (Glc)...
Abdominal diffusion-weighted imaging (DWI) has been rapidly increasing during the last few years. For evaluation of new DWI techniques, development suitable phantoms and quality assurance methods is important.To construct a body-diameter phantom for abdominal study impact different acquisition options on image quality.A with diameter 31 cm volume 26 L was constructed, containing four samples representing clinically relevant range apparent diffusion coefficient (ADC) values. Measurements were...