Blast furnace slag (SL) is an amorphous calcium aluminosilicate material that exhibits both pozzolanic and latent hydraulic activities. It has been successfully used to reduce the heat of hydration in mass concrete. However, SL currently available market generally experiences pre-treatment increase its reactivity be closer portland cement. Therefore, using such pre-treated may not applicable for reducing In this work, adiabatic semi-adiabatic temperature rise concretes with 20% 40% (mass...

We develop a pseudo-three-dimensional model of oxygen transport for the renal cortex rat, incorporating both axial and radial geometry preglomerular circulation quantitative information regarding surface areas from vasculature corpuscles. The computational was validated by simulating four sets published experimental studies oxygenation in rats. Under control conditions, predicted cortical tissue tension ([Formula: see text]) or microvascular (µPo 2 ) were within ±1 SE mean value observed...

To assess the physiological significance of arterial-to-venous (AV) oxygen shunting, we generated a new pseudo-three-dimensional computational model diffusion from intrarenal arteries to cortical tissue and veins. The combines 11 branching levels (known as “Strahler” orders) preglomerular renal vasculature in rat, with an analysis extensive data set obtained using light microscopy estimate mass transfer coefficients for each Strahler order. Furthermore, AV shunting is now within global...

The renal medulla is prone to hypoxia. Medullary hypoxia postulated be a leading cause of acute kidney injury, so there considerable interest in predicting the oxygen tension medulla. Therefore we have developed computational model for blood and transport within physiologically normal rat medulla, using multilevel modeling approach. For top-level use theory porous media advection-dispersion through realistic three-dimensional representation medulla’s gross anatomy describe flow throughout...

The objective of this study is to develop hybrid models by combining data-driven models, including support vector machines (SVM) and generalized regression neural networks (GRNN), wavelet decomposition for aggregation disaggregation rainfall. wavelet-based (WSVM) (WGRNN) are obtained using mother wavelets, db8, db10, sym8, sym10, coif6, coif12. developed evaluated in the Bocheong-stream catchment, an International Hydrological Program representative Republic Korea. WSVM WGRNN with db10 yield...

In an effort to improve drug design and predictions for pharmacokinetics (PK), empirical model was developed predict the activation energies (Ea) of cytochrome P450 (CYP450) mediated metabolism. The model, EaMEAD (Activation energy Metabolism reactions with Effective Atomic Descriptors), predicts Ea four major metabolic CYP450 enzyme: aliphatic hydroxylation, N-dealkylation, O-dealkylation, aromatic hydroxylation. To build validate E(a) values substrates diverse chemical structures (394...

Flow-diverting stents occlude aneurysms by diverting the blood flow from entering aneurysm sac. Their effectiveness is determined thrombus formation rate, which depends greatly on stent design. The aim of this study was to provide a general framework for efficient design using optimization methods, with focus hemodynamics as starting point. Kriging method used completing optimization. Three different cases idealized were considered, and 40-60 samples each case evaluated computational fluid...

The solvation free energy density (SFED) model was modified to extend its applicability and predictability. parametrization process performed with a large, diverse set of energies that included highly polar ionic molecules. mean absolute error for 1200 the 379 neutral molecules in 9 organic solvents water 0.40 kcal/mol, 90 hydration ions 1.7 kcal/mol. Overall, calculated wide range solute functional groups were consistent experimental data.

We have previously developed a three-dimensional computational model of oxygen transport in the renal medulla. In present study, we used this to quantify sensitivity medullary oxygenation four its major known determinants: blood flow (MBF), consumption rate (V̇o2,M), hemoglobin (Hb) concentration blood, and perfusion pressure. also examined under special conditions hydropenia, extracellular fluid volume expansion by infusion isotonic saline, hemodilution during cardiopulmonary bypass. Under...

This work attempts to optimize stents that are implanted at the neck of coronary or cerebral aneurysms effect a flow diversion. A two-dimensional version stent, which is series struts and gaps placed neck, considered as first step. Optimization carried out based on principles exploration design space using reductions in velocity vorticity aneurysm dome objective functions. Latin hypercube sampling develops 30–60 samples strut-gap arrangement. Flow past an with each these computed commercial...

In this study, the evolution of electro-mechanical impedance (EMI) a piezoelectric (PZT) patch embedded in fresh cement paste was investigated to discuss possibility monitoring setting process cement-based materials using an EMI sensing technique. A tailored thin square PZT before casting, and signatures were continuously measured from casting up 12 hours. standard penetration resistance test performed compare correlate during process. The results showed that responses differ according age...

The perception of rings in graphs is widely used many fields science and engineering. Algorithms developed the chemistry community, called smallest set (SSSR), applicable only for simple or chemical structures. In contrast, algorithms by computer minimum cycle basis (MCB) are identical to SSSR yet exhibit greater robustness. MCB-based can correctly reveal all any complex graph. However, they slow when applied large due inherent limitations used. Here, we suggest a heuristic method RP-Path....

Measuring crack length in concrete fracture test is not a trivial problem due to high speed propagation. In this study, mechanoluminascent (ML) material, which emits visible light under stress condition, was employed visualize propagation during test. Three-point bending conducted with notched beam specimen. The cracking images ML phenomenon were recorded by using camera as function of time and external loadings. experimental results successfully demonstrated the capability material...